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Stock Analysis on Net

Merck & Co. Inc. (NYSE:MRK)

Economic Value Added (EVA)

Microsoft Excel

Economic Profit

Merck & Co. Inc., economic profit calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Net operating profit after taxes (NOPAT)1 17,864 16,744 (714) 14,154 13,349
Cost of capital2 7.96% 7.94% 8.15% 8.13% 7.67%
Invested capital3 97,963 79,426 69,966 73,942 70,735
 
Economic profit4 10,061 10,436 (6,416) 8,141 7,920

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 NOPAT. See details »

2 Cost of capital. See details »

3 Invested capital. See details »

4 2025 Calculation
Economic profit = NOPAT – Cost of capital × Invested capital
= 17,864 – 7.96% × 97,963 = 10,061


The analysis of economic profit reveals a trajectory characterized by a severe short-term contraction followed by a strong recovery and a subsequent expansion of the capital base. While the organization demonstrated consistent value creation for the majority of the period, a significant anomaly occurred in 2023, where economic profit turned sharply negative before rebounding to levels exceeding pre-crisis figures.

Net Operating Profit After Taxes (NOPAT)
A volatile trend is observed in NOPAT, which grew from 13,349 million in 2021 to 14,154 million in 2022, before plummeting to a negative 714 million in 2023. This downturn was followed by a substantial recovery in 2024 and 2025, with NOPAT reaching 16,744 million and 17,864 million, respectively.
Invested Capital and Cost of Capital
Invested capital exhibited a general upward trend, growing from 70,735 million in 2021 to 97,963 million by 2025. A notable acceleration in capital deployment is evident between 2023 and 2025. Concurrently, the cost of capital remained relatively stable, fluctuating within a narrow range between 7.67% and 8.15%, peaking in 2023.
Economic Profit Performance
Economic profit mirrored the volatility of NOPAT, shifting from a positive 8,141 million in 2022 to a deficit of 6,416 million in 2023. Although a strong rebound occurred in 2024, reaching 10,436 million, a slight decline to 10,061 million was observed in 2025. This late-period decrease occurred despite an increase in NOPAT, suggesting that the rapid expansion of the invested capital base began to offset the gains in operating profit.

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Net Operating Profit after Taxes (NOPAT)

Merck & Co. Inc., NOPAT calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Net income attributable to Merck & Co., Inc. 18,254 17,117 365 14,519 13,049
Deferred income tax expense (benefit)1 (1,671) (1,249) (1,899) (1,568) 187
Increase (decrease) in allowance for doubtful accounts2 8 1 16 10 (5)
Increase (decrease) in LIFO reserve3 72 278 269 277 (65)
Increase (decrease) in restructuring reserves4 732 (148) 199 (124) 51
Increase (decrease) in equity equivalents5 (859) (1,118) (1,415) (1,405) 168
Interest expense 1,357 1,271 1,146 962 806
Interest expense, operating lease liability6 42 37 40 40 40
Adjusted interest expense 1,399 1,308 1,186 1,002 846
Tax benefit of interest expense7 (294) (275) (249) (210) (178)
Adjusted interest expense, after taxes8 1,105 1,033 937 792 668
(Gain) loss on marketable securities (474) 30 (411) 462 232
Interest income (343) (415) (365) (157) (36)
Investment income, before taxes (817) (385) (776) 305 196
Tax expense (benefit) of investment income9 172 81 163 (64) (41)
Investment income, after taxes10 (645) (304) (613) 241 155
(Income) loss from discontinued operations, net of tax11 — — — — (704)
Net income (loss) attributable to noncontrolling interest 9 16 12 7 13
Net operating profit after taxes (NOPAT) 17,864 16,744 (714) 14,154 13,349

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Elimination of deferred tax expense. See details »

2 Addition of increase (decrease) in allowance for doubtful accounts.

3 Addition of increase (decrease) in LIFO reserve. See details »

4 Addition of increase (decrease) in restructuring reserves.

5 Addition of increase (decrease) in equity equivalents to net income attributable to Merck & Co., Inc..

6 2025 Calculation
Interest expense on capitalized operating leases = Operating lease liability × Discount rate
= 1,195 × 3.50% = 42

7 2025 Calculation
Tax benefit of interest expense = Adjusted interest expense × Statutory income tax rate
= 1,399 × 21.00% = 294

8 Addition of after taxes interest expense to net income attributable to Merck & Co., Inc..

9 2025 Calculation
Tax expense (benefit) of investment income = Investment income, before tax × Statutory income tax rate
= 817 × 21.00% = 172

10 Elimination of after taxes investment income.

11 Elimination of discontinued operations.


Net income attributable to Merck & Co., Inc. and Net Operating Profit After Taxes (NOPAT) demonstrate distinct performance patterns over the five-year period. While net income generally exhibits an upward trajectory, NOPAT reveals a more volatile performance, including a significant decline in 2023.

Overall Trend - Net Income
Net income attributable to Merck & Co., Inc. increased from US$13,049 million in 2021 to US$14,519 million in 2022. A substantial decrease was observed in 2023, falling to US$365 million, before recovering significantly to US$17,117 million in 2024 and further increasing to US$18,254 million in 2025. This indicates a generally positive trend with a notable disruption in 2023.
Overall Trend - NOPAT
NOPAT followed a similar pattern to net income through 2022, increasing from US$13,349 million in 2021 to US$14,154 million in 2022. However, NOPAT experienced a dramatic decline in 2023, resulting in a negative value of US$-714 million. Subsequent years showed a strong recovery, with NOPAT reaching US$16,744 million in 2024 and US$17,864 million in 2025.
Comparison of Net Income and NOPAT
While both metrics generally move in the same direction, the magnitude of change differs. The decline in 2023 was far more pronounced for NOPAT than for net income. This suggests that factors impacting operating profitability, rather than solely net income, were the primary drivers of the 2023 downturn. The recovery in 2024 and 2025 was also substantial for NOPAT, indicating improved operational performance. The difference between net income and NOPAT suggests the presence of non-operating items or tax effects influencing net income.
NOPAT Volatility
The significant fluctuation in NOPAT, particularly the negative value in 2023, warrants further investigation. This volatility could be attributed to changes in operating expenses, revenue recognition, or other factors affecting the core profitability of the business. The subsequent recovery suggests these issues were addressed or were temporary in nature.

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Cash Operating Taxes

Merck & Co. Inc., cash operating taxes calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Taxes on income from continuing operations 2,804 2,803 1,512 1,918 1,521
Less: Deferred income tax expense (benefit) (1,671) (1,249) (1,899) (1,568) 187
Add: Tax savings from interest expense 294 275 249 210 178
Less: Tax imposed on investment income 172 81 163 (64) (41)
Cash operating taxes 4,597 4,246 3,497 3,760 1,553

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).


The reported taxes on income from continuing operations exhibited fluctuations over the five-year period. Initial values increased from 2021 to 2022, followed by a decrease in 2023, and then a substantial rise in 2024 and 2025, remaining relatively stable between those final two years. However, a more pronounced trend is observed in cash operating taxes.

Cash Operating Taxes Trend
Cash operating taxes demonstrate a significant increase from 2021 to 2022, nearly doubling from US$1,553 million to US$3,760 million. This increase is followed by a moderate decline in 2023 to US$3,497 million. Subsequent years, 2024 and 2025, show continued growth, reaching US$4,246 million and US$4,597 million respectively. The pattern suggests a generally increasing tax burden as measured by cash outflows.

The divergence between taxes on income from continuing operations and cash operating taxes is notable. While income taxes fluctuated, cash operating taxes consistently increased over the period, albeit with a slight dip in 2023. This difference could be attributable to timing differences between reported income tax expense and actual cash payments, such as deferred tax assets or liabilities, or changes in tax credits utilized. The substantial increase in cash operating taxes from 2021 to 2022 warrants further investigation to understand the underlying drivers, potentially including changes in tax laws, profitability, or the utilization of tax loss carryforwards.

Comparative Analysis
The difference between the two tax measures widened considerably in 2022 and remained elevated through 2025. In 2021, the difference was US$32 million. By 2022, this difference grew to US$1,842 million. While the gap narrowed somewhat in 2023 (US$1,985 million), it expanded again in 2024 (US$1,443 million) and 2025 (US$1,793 million). This sustained difference suggests a significant impact on free cash flow and should be considered when evaluating economic value added.

The consistent upward trend in cash operating taxes, particularly when contrasted with the more volatile reported income taxes, indicates a growing cash commitment to tax obligations. This trend should be monitored closely as it directly impacts available cash for reinvestment, debt reduction, or shareholder returns.

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Invested Capital

Merck & Co. Inc., invested capital calculation (financing approach)

US$ in millions

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Loans payable and current portion of long-term debt 2,589 2,649 1,372 1,946 2,412
Long-term debt, excluding current portion 46,750 34,462 33,683 28,745 30,690
Operating lease liability1 1,195 1,159 1,213 1,294 1,529
Total reported debt & leases 50,534 38,270 36,268 31,985 34,631
Total Merck & Co., Inc. stockholders’ equity 52,606 46,313 37,581 45,991 38,184
Net deferred tax (assets) liabilities2 (1,166) (2,214) (1,097) 1,292 2,749
Allowance for doubtful accounts3 97 89 88 72 62
LIFO reserve4 912 840 562 293 16
Restructuring reserves5 1,296 564 712 513 637
Equity equivalents6 1,139 (721) 265 2,170 3,464
Accumulated other comprehensive (income) loss, net of tax7 4,287 4,945 5,161 4,768 4,429
Noncontrolling interests 56 59 54 67 73
Adjusted total Merck & Co., Inc. stockholders’ equity 58,088 50,596 43,061 52,996 46,150
Construction in progress8 (9,166) (7,984) (8,262) (9,186) (8,313)
Investments in debt and publicly traded equity securities9 (1,493) (1,456) (1,101) (1,853) (1,733)
Invested capital 97,963 79,426 69,966 73,942 70,735

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Addition of capitalized operating leases.

2 Elimination of deferred taxes from assets and liabilities. See details »

3 Addition of allowance for doubtful accounts receivable.

4 Addition of LIFO reserve. See details »

5 Addition of restructuring reserves.

6 Addition of equity equivalents to total Merck & Co., Inc. stockholders’ equity.

7 Removal of accumulated other comprehensive income.

8 Subtraction of construction in progress.

9 Subtraction of investments in debt and publicly traded equity securities.


The invested capital of the company exhibited fluctuations over the five-year period. Total reported debt & leases and total stockholders’ equity both contribute to the calculation of invested capital, and their individual trends influence the overall invested capital figure.

Invested Capital Trend
Invested capital increased from US$70,735 million in 2021 to US$73,942 million in 2022, representing a growth of approximately 4.5%. A subsequent decrease was observed in 2023, with invested capital falling to US$69,966 million. This was followed by a more substantial increase in 2024, reaching US$79,426 million, and continued growth in 2025 to US$97,963 million. The most significant increase occurred between 2024 and 2025.
Debt & Leases
Total reported debt & leases decreased from US$34,631 million in 2021 to US$31,985 million in 2022. An increase was then noted in 2023, reaching US$36,268 million, and continued into 2024 with a value of US$38,270 million. A considerable rise occurred in 2025, with debt & leases reaching US$50,534 million. This suggests a shift towards increased reliance on debt financing in the latter part of the period.
Stockholders’ Equity
Total stockholders’ equity increased significantly from US$38,184 million in 2021 to US$45,991 million in 2022. A decrease was observed in 2023, with equity falling to US$37,581 million. Equity then rebounded in 2024 to US$46,313 million and continued to grow in 2025, reaching US$52,606 million. The fluctuations in equity likely reflect retained earnings, share issuances, and share repurchases.

The combined effect of these trends in debt and equity resulted in the overall pattern observed in invested capital. The substantial increase in invested capital between 2024 and 2025 appears to be driven by a combination of increased debt and equity, with debt contributing a larger proportion of the growth.

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Cost of Capital

Merck & Co. Inc., cost of capital calculations

Capital (fair value)1 Weights Cost of capital
Equity2 306,404 306,404 ÷ 353,199 = 0.87 0.87 × 8.71% = 7.56%
Loans payable and long-term debt, including current portion3 45,600 45,600 ÷ 353,199 = 0.13 0.13 × 3.89% × (1 – 21.00%) = 0.40%
Operating lease liability4 1,195 1,195 ÷ 353,199 = 0.00 0.00 × 3.50% × (1 – 21.00%) = 0.01%
Total: 353,199 1.00 7.96%

Based on: 10-K (reporting date: 2025-12-31).

1 US$ in millions

2 Equity. See details »

3 Loans payable and long-term debt, including current portion. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 230,955 230,955 ÷ 264,714 = 0.87 0.87 × 8.71% = 7.60%
Loans payable and long-term debt, including current portion3 32,600 32,600 ÷ 264,714 = 0.12 0.12 × 3.39% × (1 – 21.00%) = 0.33%
Operating lease liability4 1,159 1,159 ÷ 264,714 = 0.00 0.00 × 3.20% × (1 – 21.00%) = 0.01%
Total: 264,714 1.00 7.94%

Based on: 10-K (reporting date: 2024-12-31).

1 US$ in millions

2 Equity. See details »

3 Loans payable and long-term debt, including current portion. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 326,306 326,306 ÷ 359,519 = 0.91 0.91 × 8.71% = 7.91%
Loans payable and long-term debt, including current portion3 32,000 32,000 ÷ 359,519 = 0.09 0.09 × 3.32% × (1 – 21.00%) = 0.23%
Operating lease liability4 1,213 1,213 ÷ 359,519 = 0.00 0.00 × 3.30% × (1 – 21.00%) = 0.01%
Total: 359,519 1.00 8.15%

Based on: 10-K (reporting date: 2023-12-31).

1 US$ in millions

2 Equity. See details »

3 Loans payable and long-term debt, including current portion. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 278,966 278,966 ÷ 306,960 = 0.91 0.91 × 8.71% = 7.92%
Loans payable and long-term debt, including current portion3 26,700 26,700 ÷ 306,960 = 0.09 0.09 × 2.95% × (1 – 21.00%) = 0.20%
Operating lease liability4 1,294 1,294 ÷ 306,960 = 0.00 0.00 × 3.10% × (1 – 21.00%) = 0.01%
Total: 306,960 1.00 8.13%

Based on: 10-K (reporting date: 2022-12-31).

1 US$ in millions

2 Equity. See details »

3 Loans payable and long-term debt, including current portion. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 192,917 192,917 ÷ 230,146 = 0.84 0.84 × 8.71% = 7.30%
Loans payable and long-term debt, including current portion3 35,700 35,700 ÷ 230,146 = 0.16 0.16 × 2.92% × (1 – 21.00%) = 0.36%
Operating lease liability4 1,529 1,529 ÷ 230,146 = 0.01 0.01 × 2.60% × (1 – 21.00%) = 0.01%
Total: 230,146 1.00 7.67%

Based on: 10-K (reporting date: 2021-12-31).

1 US$ in millions

2 Equity. See details »

3 Loans payable and long-term debt, including current portion. See details »

4 Operating lease liability. See details »


Economic Spread Ratio

Merck & Co. Inc., economic spread ratio calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Selected Financial Data (US$ in millions)
Economic profit1 10,061 10,436 (6,416) 8,141 7,920
Invested capital2 97,963 79,426 69,966 73,942 70,735
Performance Ratio
Economic spread ratio3 10.27% 13.14% -9.17% 11.01% 11.20%
Benchmarks
Economic Spread Ratio, Competitors4
AbbVie Inc. 0.54% -2.40% -4.11% 5.32% 4.71%
Amgen Inc. 6.11% -0.67% 2.15% 6.66% 6.66%
Bristol-Myers Squibb Co. 5.48% -22.18% 1.38% -1.40% 0.91%
Danaher Corp. -10.72% -10.89% -11.66% -6.65% -5.82%
Eli Lilly & Co. 29.94% 14.28% 1.21% 8.31% 9.99%
Gilead Sciences Inc. 12.42% -10.66% 2.68% -0.45% 6.60%
Johnson & Johnson 11.34% 1.67% -0.18% 5.09% 10.15%
Pfizer Inc. -3.81% -3.50% -9.60% 17.82% 10.99%
Regeneron Pharmaceuticals Inc. 13.62% 16.44% 13.24% 18.61% 62.36%
Thermo Fisher Scientific Inc. -7.47% -8.27% -8.74% -6.99% -4.97%
Vertex Pharmaceuticals Inc. 20.56% -23.09% 10.85% 13.60% 14.81%

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Economic profit. See details »

2 Invested capital. See details »

3 2025 Calculation
Economic spread ratio = 100 × Economic profit ÷ Invested capital
= 100 × 10,061 ÷ 97,963 = 10.27%

4 Click competitor name to see calculations.


The analysis of economic value added indicates a period of significant volatility between 2021 and 2025, characterized by a sharp decline in performance during 2023 followed by a robust recovery in 2024 and subsequent stabilization in 2025.

Economic Spread Ratio
The economic spread ratio remained relatively stable between 2021 and 2022, moving from 11.20% to 11.01%. A severe contraction occurred in 2023, where the ratio plummeted to -9.17%, indicating that the return on invested capital fell below the cost of capital during that period. A strong rebound was observed in 2024, with the ratio reaching a five-year peak of 13.14%, before moderating to 10.27% by the end of 2025.
Economic Profit
Economic profit trends mirrored the spread ratio, starting at 7,920 million USD in 2021 and increasing slightly to 8,141 million USD in 2022. The 2023 fiscal year saw a substantial reversal, resulting in a negative economic profit of -6,416 million USD. Recovery was swift in 2024, with profit climbing to 10,436 million USD, while 2025 showed a slight decrease to 10,061 million USD.
Invested Capital
Invested capital exhibited a general upward trajectory over the period, despite a minor decrease in 2023 to 69,966 million USD. From 2023 to 2025, a significant expansion in the capital base is evident, with invested capital rising to 79,426 million USD in 2024 and further increasing to 97,963 million USD by December 31, 2025. This suggests a substantial increase in the resources deployed to generate economic value.

The correlation between the decline in economic profit and the negative economic spread ratio in 2023 suggests a temporary misalignment between capital costs and returns. However, the subsequent increase in both invested capital and the spread ratio in 2024 indicates a successful scaling of operations and an improved ability to generate value above the required rate of return.

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Economic Profit Margin

Merck & Co. Inc., economic profit margin calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Selected Financial Data (US$ in millions)
Economic profit1 10,061 10,436 (6,416) 8,141 7,920
Sales 65,011 64,168 60,115 59,283 48,704
Performance Ratio
Economic profit margin2 15.48% 16.26% -10.67% 13.73% 16.26%
Benchmarks
Economic Profit Margin, Competitors3
AbbVie Inc. 0.54% -2.95% -5.16% 7.52% 8.04%
Amgen Inc. 10.18% -1.32% 5.60% 10.67% 11.04%
Bristol-Myers Squibb Co. 6.74% -28.77% 2.07% -2.18% 1.57%
Danaher Corp. -32.86% -33.60% -38.27% -16.51% -14.53%
Eli Lilly & Co. 22.79% 11.35% 1.04% 7.07% 9.22%
Gilead Sciences Inc. 18.38% -16.51% 4.56% -0.76% 11.67%
Johnson & Johnson 16.64% 2.01% -0.21% 6.10% 10.61%
Pfizer Inc. -8.52% -7.44% -24.97% 19.50% 11.73%
Regeneron Pharmaceuticals Inc. 12.58% 14.42% 12.08% 18.73% 42.17%
Thermo Fisher Scientific Inc. -15.79% -15.83% -17.45% -12.89% -10.11%
Vertex Pharmaceuticals Inc. 18.13% -18.96% 14.56% 20.07% 18.36%

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Economic profit. See details »

2 2025 Calculation
Economic profit margin = 100 × Economic profit ÷ Sales
= 100 × 10,061 ÷ 65,011 = 15.48%

3 Click competitor name to see calculations.


The financial trajectory from 2021 to 2025 is characterized by consistent top-line growth contrasted with significant volatility in economic value creation. While sales increased steadily throughout the period, economic profit experienced a severe contraction in 2023 before rebounding to peak levels in 2024 and 2025.

Sales Growth Trend
A consistent upward trend in sales is observed, with revenue increasing from 48,704 million USD in 2021 to 65,011 million USD by 2025. This represents steady organic or inorganic expansion of the market presence over the five-year period.
Economic Profit Volatility
Economic profit demonstrated instability, moving from 7,920 million USD in 2021 to a peak of 8,141 million USD in 2022, before plummeting to a negative 6,416 million USD in 2023. This sharp decline indicates a period where the company failed to generate returns exceeding its cost of capital. However, a strong recovery followed, with economic profit reaching its highest point of 10,436 million USD in 2024, before settling at 10,061 million USD in 2025.
Economic Profit Margin Analysis
The economic profit margin mirrors the volatility of the absolute economic profit. The margin declined from 16.26% in 2021 to 13.73% in 2022, falling further to -10.67% in 2023. The recovery in 2024 saw the margin return exactly to its 2021 level of 16.26%, followed by a slight moderation to 15.48% in 2025. This pattern suggests that while revenue growth remained stable, the efficiency of generating economic value was severely disrupted in 2023 but successfully restored in subsequent years.

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