Stock Analysis on Net

Eli Lilly & Co. (NYSE:LLY)

$24.99

Economic Value Added (EVA)

Microsoft Excel

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Economic Profit

Eli Lilly & Co., economic profit calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Net operating profit after taxes (NOPAT)1
Cost of capital2
Invested capital3
 
Economic profit4

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 NOPAT. See details »

2 Cost of capital. See details »

3 Invested capital. See details »

4 2025 Calculation
Economic profit = NOPAT – Cost of capital × Invested capital
= × =


The period demonstrates significant fluctuations in economic profit, driven by changes in net operating profit after taxes (NOPAT), cost of capital, and invested capital. An initial decline in economic profit is followed by substantial growth in later years.

Net Operating Profit After Taxes (NOPAT)
NOPAT decreased from US$5,065 million in 2021 to US$3,228 million in 2023, indicating a weakening in operational profitability. However, a strong recovery is evident in 2024 and 2025, with NOPAT reaching US$8,605 million and US$19,711 million respectively. This suggests a significant improvement in the company’s core business performance in the latter part of the period.
Cost of Capital
The cost of capital experienced a modest increase from 8.73% in 2021 to 9.10% in 2025. While the increase is relatively small, it represents a growing expense associated with financing the company’s operations and investments. The rate remained relatively stable between 2024 and 2025.
Invested Capital
Invested capital followed a fluctuating pattern. It decreased from US$26,117 million in 2021 to US$24,287 million in 2022, then increased to US$29,370 million in 2023. Further substantial increases are observed in 2024 (US$35,786 million) and 2025 (US$49,610 million), indicating significant capital deployment during these years.
Economic Profit
Economic profit mirrored the trends in NOPAT. It declined from US$2,784 million in 2021 to US$561 million in 2023, reflecting the decrease in operational profitability. A substantial turnaround occurred in 2024 and 2025, with economic profit rising to US$5,361 million and US$15,198 million respectively. This indicates that the company is generating returns exceeding its cost of capital in the later years of the period, and the magnitude of this excess is growing.

The observed trends suggest a period of initial challenges followed by a strong recovery and growth phase. The significant increase in both NOPAT and invested capital in 2024 and 2025 appears to be the primary driver of the substantial improvement in economic profit. The modest increase in the cost of capital did not offset the gains from improved profitability and capital deployment.


Net Operating Profit after Taxes (NOPAT)

Eli Lilly & Co., NOPAT calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Net income
Deferred income tax expense (benefit)1
Increase (decrease) in LIFO reserve2
Increase (decrease) in equity equivalents3
Interest expense on borrowings
Interest expense, operating lease liability4
Adjusted interest expense on borrowings
Tax benefit of interest expense on borrowings5
Adjusted interest expense on borrowings, after taxes6
Net operating profit after taxes (NOPAT)

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Elimination of deferred tax expense. See details »

2 Addition of increase (decrease) in LIFO reserve. See details »

3 Addition of increase (decrease) in equity equivalents to net income.

4 2025 Calculation
Interest expense on capitalized operating leases = Operating lease liability × Discount rate
= × =

5 2025 Calculation
Tax benefit of interest expense on borrowings = Adjusted interest expense on borrowings × Statutory income tax rate
= × 21.00% =

6 Addition of after taxes interest expense to net income.


Net income and net operating profit after taxes (NOPAT) exhibited distinct trends over the five-year period. While net income generally increased, NOPAT demonstrated a more complex pattern of fluctuation.

NOPAT Trend
NOPAT decreased from US$5,065 million in 2021 to US$3,228 million in 2023, representing a substantial decline over two years. This downward trend reversed in 2024, with NOPAT increasing significantly to US$8,605 million. The most substantial growth occurred between 2024 and 2025, with NOPAT reaching US$19,711 million. This indicates a considerable improvement in core operational profitability in the latter part of the period.
Relationship between Net Income and NOPAT
Although both metrics generally moved in the same direction, the magnitude of change differed. Net income increased from US$5,582 million in 2021 to US$6,245 million in 2022, then decreased to US$5,240 million in 2023, before experiencing substantial growth in 2024 and 2025, reaching US$20,640 million. The difference between net income and NOPAT suggests that factors beyond core operations, such as financing costs or non-operating income, played an increasingly significant role in determining overall net income, particularly in 2024 and 2025.

The substantial increase in NOPAT from 2023 to 2025 suggests improved operational efficiency, increased sales volume, or a combination of both. Further investigation would be required to determine the specific drivers of this improvement. The divergence between net income and NOPAT trends warrants further scrutiny to understand the impact of non-operating items on overall profitability.


Cash Operating Taxes

Eli Lilly & Co., cash operating taxes calculation

US$ in millions

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Income taxes
Less: Deferred income tax expense (benefit)
Add: Tax savings from interest expense on borrowings
Cash operating taxes

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).


A significant increase in both income taxes and cash operating taxes is observed over the five-year period. While income taxes demonstrate substantial growth, cash operating taxes exhibit a more pronounced and consistent upward trajectory.

Income Taxes
Income taxes remained relatively stable between 2021 and 2022, fluctuating between US$562 million and US$574 million. A substantial increase is then noted in 2023, reaching US$1,314 million, followed by further increases to US$2,090 million in 2024 and US$5,091 million in 2025. This represents a nearly nine-fold increase over the 2021 level.
Cash Operating Taxes
Cash operating taxes demonstrate a consistent upward trend throughout the period. Beginning at US$1,452 million in 2021, they more than doubled to US$2,822 million in 2022. Continued growth is evident in subsequent years, reaching US$3,767 million in 2023, US$4,949 million in 2024, and US$6,999 million in 2025. This represents a nearly five-fold increase over the 2021 level.
Relationship between Income Taxes and Cash Operating Taxes
While both metrics increase, cash operating taxes consistently exceed income taxes throughout the observed period. The difference between the two widens over time, suggesting increasing tax payments beyond the reported income tax expense. This divergence could be attributable to various factors, including timing differences between accounting and cash tax liabilities, changes in tax regulations, or the utilization of tax loss carryforwards. The substantial growth in cash operating taxes, particularly in the later years, warrants further investigation to understand the underlying drivers and potential implications for future cash flows.

The observed trends suggest a growing tax burden for the company. The significant increase in cash operating taxes, exceeding the growth in reported income taxes, indicates a potential shift in the company’s tax profile and requires further scrutiny.


Invested Capital

Eli Lilly & Co., invested capital calculation (financing approach)

US$ in millions

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Short-term borrowings and current maturities of long-term debt
Long-term debt, excluding current maturities
Operating lease liability1
Total reported debt & leases
Total Eli Lilly and Company shareholders’ equity
Net deferred tax (assets) liabilities2
LIFO reserve3
Equity equivalents4
Accumulated other comprehensive (income) loss, net of tax5
Noncontrolling interests
Adjusted total Eli Lilly and Company shareholders’ equity
Construction in progress6
Marketable securities7
Invested capital

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Addition of capitalized operating leases.

2 Elimination of deferred taxes from assets and liabilities. See details »

3 Addition of LIFO reserve. See details »

4 Addition of equity equivalents to total Eli Lilly and Company shareholders’ equity.

5 Removal of accumulated other comprehensive income.

6 Subtraction of construction in progress.

7 Subtraction of marketable securities.


The reported invested capital exhibited a fluctuating pattern over the five-year period. Total reported debt & leases and total shareholders’ equity both contributed to the overall invested capital figure, with notable changes observed in both components.

Invested Capital Trend
Invested capital decreased from US$26,117 million in 2021 to US$24,287 million in 2022, representing a decline of approximately 6.7%. Subsequently, invested capital increased to US$29,370 million in 2023, US$35,786 million in 2024, and further to US$49,610 million in 2025. This indicates a substantial growth trend in invested capital from 2022 through 2025.
Debt & Leases
Total reported debt & leases decreased from US$17,570 million in 2021 to US$16,967 million in 2022. However, beginning in 2023, a consistent and significant increase in debt & leases is observed, rising to US$26,330 million, US$34,791 million, and ultimately US$43,865 million in 2025. This represents a considerable reliance on debt financing over the latter part of the analyzed period.
Shareholders’ Equity
Total shareholders’ equity demonstrated an initial increase from US$8,979 million in 2021 to US$10,650 million in 2022, and a slight increase to US$10,772 million in 2023. A more pronounced growth in shareholders’ equity is then evident in 2024 and 2025, reaching US$14,192 million and US$26,535 million respectively. This suggests increasing internal funding sources alongside the growing debt levels.

The combined effect of increasing debt and shareholders’ equity resulted in the overall upward trend in invested capital from 2022 onwards. The rate of increase in invested capital accelerated in the later years, driven primarily by the substantial growth in both debt and equity financing.


Cost of Capital

Eli Lilly & Co., cost of capital calculations

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Debt3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2025-12-31).

1 US$ in millions

2 Equity. See details »

3 Debt. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Debt3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2024-12-31).

1 US$ in millions

2 Equity. See details »

3 Debt. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Debt3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2023-12-31).

1 US$ in millions

2 Equity. See details »

3 Debt. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Debt3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2022-12-31).

1 US$ in millions

2 Equity. See details »

3 Debt. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Debt3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2021-12-31).

1 US$ in millions

2 Equity. See details »

3 Debt. See details »

4 Operating lease liability. See details »


Economic Spread Ratio

Eli Lilly & Co., economic spread ratio calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Selected Financial Data (US$ in millions)
Economic profit1
Invested capital2
Performance Ratio
Economic spread ratio3
Benchmarks
Economic Spread Ratio, Competitors4
AbbVie Inc.
Amgen Inc.
Bristol-Myers Squibb Co.
Danaher Corp.
Gilead Sciences Inc.
Johnson & Johnson
Merck & Co. Inc.
Pfizer Inc.
Regeneron Pharmaceuticals Inc.
Thermo Fisher Scientific Inc.
Vertex Pharmaceuticals Inc.

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Economic profit. See details »

2 Invested capital. See details »

3 2025 Calculation
Economic spread ratio = 100 × Economic profit ÷ Invested capital
= 100 × ÷ =

4 Click competitor name to see calculations.


The economic spread ratio demonstrates a fluctuating pattern over the five-year period. Initial values indicate a relatively strong economic spread, which subsequently declined before experiencing substantial growth.

Economic Spread Ratio Trend
In 2021, the economic spread ratio stood at 10.66%. A decrease was observed in 2022, with the ratio falling to 9.01%. This downward trend continued into 2023, with a significant decline to 1.91%, representing the lowest value within the observed timeframe. A substantial recovery began in 2024, as the ratio increased to 14.98%. This positive momentum accelerated in 2025, reaching 30.63%, the highest value recorded.

The economic spread ratio’s movement correlates with changes in economic profit and invested capital. The initial decline in the ratio coincided with a decrease in economic profit from 2021 to 2023, despite fluctuations in invested capital. The subsequent increase in the ratio from 2024 onwards is linked to a significant rise in economic profit, coupled with a continued increase in invested capital. This suggests an increasing ability to generate returns exceeding the cost of capital.

Relationship to Economic Profit and Invested Capital
The economic spread ratio is calculated as economic profit divided by invested capital. The substantial increase in the ratio in 2024 and 2025 is primarily driven by the significant growth in economic profit, which outpaced the growth in invested capital. This indicates improved efficiency in capital allocation and utilization.

The considerable increase in the economic spread ratio in the latter years of the period suggests a strengthening of the company’s competitive advantage and its ability to create value for its investors. The trend warrants further investigation to understand the underlying drivers of the improved performance and to assess its sustainability.


Economic Profit Margin

Eli Lilly & Co., economic profit margin calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Selected Financial Data (US$ in millions)
Economic profit1
Revenue
Performance Ratio
Economic profit margin2
Benchmarks
Economic Profit Margin, Competitors3
AbbVie Inc.
Amgen Inc.
Bristol-Myers Squibb Co.
Danaher Corp.
Gilead Sciences Inc.
Johnson & Johnson
Merck & Co. Inc.
Pfizer Inc.
Regeneron Pharmaceuticals Inc.
Thermo Fisher Scientific Inc.
Vertex Pharmaceuticals Inc.

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).

1 Economic profit. See details »

2 2025 Calculation
Economic profit margin = 100 × Economic profit ÷ Revenue
= 100 × ÷ =

3 Click competitor name to see calculations.


The economic profit exhibited considerable fluctuation over the five-year period. Initially, a decline in economic profit was observed, followed by a substantial increase in later years. This trend is reflected in the economic profit margin, which demonstrates a similar pattern of initial decrease, followed by significant growth.

Economic Profit
Economic profit decreased from US$2,784 million in 2021 to US$2,187 million in 2022, representing a decline of approximately 21.5%. A more pronounced decrease occurred in 2023, with economic profit falling to US$561 million. However, a strong recovery was evident in 2024, with economic profit reaching US$5,361 million, and continued to rise significantly in 2025 to US$15,198 million.
Revenue
Revenue demonstrated a consistent upward trend throughout the period. It increased from US$28,318 million in 2021 to US$28,541 million in 2022, a modest increase. Growth accelerated in 2023, reaching US$34,124 million, and continued to increase substantially to US$45,043 million in 2024 and US$65,179 million in 2025.
Economic Profit Margin
The economic profit margin mirrored the trend in economic profit. It decreased from 9.83% in 2021 to 7.66% in 2022. The most significant decline was observed in 2023, falling to 1.65%. A substantial increase began in 2024, with the margin rising to 11.90%, and continued to climb sharply in 2025, reaching 23.32%. This indicates that the company is becoming increasingly efficient at generating economic profit from its revenue.

The substantial increase in both economic profit and economic profit margin in 2024 and 2025 suggests improved operational efficiency, effective cost management, or increased pricing power. The earlier decline in 2022 and 2023, despite revenue growth, warrants further investigation to understand the underlying factors contributing to reduced profitability.