Stock Analysis on Net

Vertex Pharmaceuticals Inc. (NASDAQ:VRTX)

$24.99

Economic Value Added (EVA)

Microsoft Excel

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Economic Profit

Vertex Pharmaceuticals Inc., economic profit calculation

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Net operating profit after taxes (NOPAT)1
Cost of capital2
Invested capital3
 
Economic profit4

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

1 NOPAT. See details »

2 Cost of capital. See details »

3 Invested capital. See details »

4 2024 Calculation
Economic profit = NOPAT – Cost of capital × Invested capital
= × =


The financial data reflects various trends over the five-year period ending in 2024. Below is a detailed analysis of the key metrics provided.

Net Operating Profit After Taxes (NOPAT)
The NOPAT exhibited a downward trend from 2020 to 2021, decreasing from approximately $3.02 billion to $2.24 billion. It rebounded in 2022 to nearly $3.0 billion before declining again in 2023 to approximately $2.64 billion. Notably, in 2024, NOPAT turned negative, reaching around -$1.27 billion, indicating a significant reversal in operating profitability.
Cost of Capital
The cost of capital remained relatively stable throughout the period, fluctuating narrowly between 8.59% and 8.63%. This consistency suggests a stable risk profile and financing environment from the perspective of capital costs.
Invested Capital
Invested capital increased substantially from 2020 to 2022, rising from approximately $8.14 billion to $13.18 billion. The level remained almost constant into 2023 at about $13.24 billion. However, a sharp contraction occurred by 2024, where invested capital decreased significantly to about $9.05 billion. This decline might indicate asset disposals, divestitures, or writedowns.
Economic Profit
Economic profit showed a declining pattern similar to NOPAT. It dropped from roughly $2.32 billion in 2020 to about $1.43 billion in 2021, then partially recovered to $1.85 billion in 2022 before dropping again to approximately $1.50 billion in 2023. In 2024, economic profit became negative at about -$2.05 billion, signaling that the return on invested capital fell below the cost of capital, resulting in value destruction.

Overall, the data indicates a period of growth in invested capital accompanied by fluctuating profitability through 2023. However, 2024 shows a marked deterioration with negative operating profit and economic profit, alongside a reduction in invested capital. This suggests significant operational and investment challenges impacting financial performance and value creation in the latest year.


Net Operating Profit after Taxes (NOPAT)

Vertex Pharmaceuticals Inc., NOPAT calculation

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Net income (loss)
Deferred income tax expense (benefit)1
Increase (decrease) in equity equivalents2
Interest expense
Interest expense, operating lease liability3
Adjusted interest expense
Tax benefit of interest expense4
Adjusted interest expense, after taxes5
(Gain) loss on marketable securities
Interest income
Investment income, before taxes
Tax expense (benefit) of investment income6
Investment income, after taxes7
Net operating profit after taxes (NOPAT)

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

1 Elimination of deferred tax expense. See details »

2 Addition of increase (decrease) in equity equivalents to net income (loss).

3 2024 Calculation
Interest expense on capitalized operating leases = Operating lease liability × Discount rate
= × =

4 2024 Calculation
Tax benefit of interest expense = Adjusted interest expense × Statutory income tax rate
= × 21.00% =

5 Addition of after taxes interest expense to net income (loss).

6 2024 Calculation
Tax expense (benefit) of investment income = Investment income, before tax × Statutory income tax rate
= × 21.00% =

7 Elimination of after taxes investment income.


Net Income (Loss)

The net income displayed an initial fluctuation with a decline from approximately 2.71 billion US dollars in 2020 to 2.34 billion US dollars in 2021. This was followed by a notable recovery reaching about 3.32 billion US dollars in 2022 and a further increase to approximately 3.62 billion US dollars in 2023. However, there was a significant reversal in 2024, with net income turning negative, resulting in a loss of approximately 536 million US dollars. This indicates a considerable downturn or an extraordinary expense impacting profitability in 2024.

Net Operating Profit After Taxes (NOPAT)

The NOPAT value exhibited a similar pattern to net income but with some differences in magnitude and trend continuation. It started at around 3.02 billion US dollars in 2020 but dropped substantially to about 2.24 billion US dollars in 2021. There was a recovery in 2022 to nearly 3 billion US dollars; however, unlike net income that increased in 2023, NOPAT decreased to approximately 2.64 billion US dollars. In 2024, the NOPAT also turned negative, with a loss of about 1.27 billion US dollars, representing an even more pronounced operational challenge than indicated by net income alone.

Summary of Trends and Insights

Both profitability measures show volatility over the five-year period with initial declines, strong recoveries, and significant downturns at the end of the period. The negative figures in 2024 for both net income and NOPAT highlight a substantial deterioration in performance. The larger negative NOPAT compared to net income in 2024 suggests a more severe erosion of operational efficiency or higher operating costs that may not be fully captured in net income calculations. These trends warrant further investigation into underlying causes such as market conditions, cost management, one-time charges, or other financial events impacting the company's profitability in the latest period.


Cash Operating Taxes

Vertex Pharmaceuticals Inc., cash operating taxes calculation

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Provision for income taxes
Less: Deferred income tax expense (benefit)
Add: Tax savings from interest expense
Less: Tax imposed on investment income
Cash operating taxes

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).


Provision for income taxes
The provision for income taxes displayed fluctuations over the observed period. It decreased from 405,151 thousand US dollars in 2020 to 388,300 thousand US dollars in 2021, indicating a slight reduction. However, in 2022, there was a significant increase to 910,400 thousand US dollars. Following this peak, the provision decreased somewhat in 2023 to 760,200 thousand US dollars and then showed a moderate increase again in 2024, reaching 784,100 thousand US dollars. Overall, the trend indicates heightened income tax provisions after 2021, with some volatility but maintaining higher levels than in the initial years.
Cash operating taxes
Cash operating taxes exhibited a strong upward trend from 2020 through 2023. Starting at 137,080 thousand US dollars in 2020, the cash taxes increased substantially to 556,675 thousand in 2021. This upward trajectory continued sharply into 2022, nearly doubling to 1,170,431 thousand US dollars. The peak was maintained in 2023 with 1,178,814 thousand US dollars, indicating stable but very high cash tax payments during that year. In 2024, cash operating taxes decreased to 1,029,919 thousand US dollars, showing a notable decline but remaining considerably elevated compared to 2020 and 2021.
Comparative Insights
Both provision for income taxes and cash operating taxes increased considerably after 2021, with cash operating taxes showing a more pronounced and consistent rise through 2023. The provision for income taxes experienced a sharp spike in 2022, followed by some reduction but remaining high through 2024. Cash operating taxes, while declining in 2024, stayed substantially higher than earlier years. This pattern could indicate changes in taxable income, tax planning strategies, or tax rate adjustments, resulting in elevated tax-related expenses and payments in recent years.

Invested Capital

Vertex Pharmaceuticals Inc., invested capital calculation (financing approach)

US$ in thousands

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Current finance lease liabilities
Long-term finance lease liabilities
Operating lease liability1
Total reported debt & leases
Shareholders’ equity
Net deferred tax (assets) liabilities2
Equity equivalents3
Accumulated other comprehensive (income) loss, net of tax4
Adjusted shareholders’ equity
Marketable securities5
Invested capital

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

1 Addition of capitalized operating leases.

2 Elimination of deferred taxes from assets and liabilities. See details »

3 Addition of equity equivalents to shareholders’ equity.

4 Removal of accumulated other comprehensive income.

5 Subtraction of marketable securities.


Total Reported Debt & Leases
The total reported debt and leases experienced a general decline from 2020 through 2023, decreasing from 942,460 thousand US dollars to 808,400 thousand US dollars. However, in 2024, there was a significant increase to 1,749,500 thousand US dollars, more than doubling the previous year's figure. This suggests a notable rise in leverage or financing activities in the most recent year.
Shareholders’ Equity
Shareholders' equity demonstrated a consistent upward trend from 2020 to 2023, increasing from 8,686,815 thousand US dollars to 17,580,400 thousand US dollars. This growth reflects an accumulation of retained earnings or capital injections over the years. In 2024, there was a slight decline to 16,409,600 thousand US dollars, indicating a minor reduction in equity, which may reflect distributions to shareholders, losses, or other equity adjustments.
Invested Capital
Invested capital rose steadily from 8,144,266 thousand US dollars in 2020 to 13,278,000 thousand US dollars in 2022. A plateau occurred between 2022 and 2023 with a marginal increase to 13,244,000 thousand US dollars. This was followed by a substantial decrease in 2024 to 9,046,000 thousand US dollars. This pattern may indicate a reduction in operating assets or a strategic realignment of capital deployment in the most recent period.

Cost of Capital

Vertex Pharmaceuticals Inc., cost of capital calculations

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Finance lease liabilities3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2024-12-31).

1 US$ in thousands

2 Equity. See details »

3 Finance lease liabilities. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Finance lease liabilities3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2023-12-31).

1 US$ in thousands

2 Equity. See details »

3 Finance lease liabilities. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Finance lease liabilities3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2022-12-31).

1 US$ in thousands

2 Equity. See details »

3 Finance lease liabilities. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Finance lease liabilities3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2021-12-31).

1 US$ in thousands

2 Equity. See details »

3 Finance lease liabilities. See details »

4 Operating lease liability. See details »

Capital (fair value)1 Weights Cost of capital
Equity2 ÷ = × =
Finance lease liabilities3 ÷ = × × (1 – 21.00%) =
Operating lease liability4 ÷ = × × (1 – 21.00%) =
Total:

Based on: 10-K (reporting date: 2020-12-31).

1 US$ in thousands

2 Equity. See details »

3 Finance lease liabilities. See details »

4 Operating lease liability. See details »


Economic Spread Ratio

Vertex Pharmaceuticals Inc., economic spread ratio calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Selected Financial Data (US$ in thousands)
Economic profit1
Invested capital2
Performance Ratio
Economic spread ratio3
Benchmarks
Economic Spread Ratio, Competitors4
AbbVie Inc.
Amgen Inc.
Bristol-Myers Squibb Co.
Danaher Corp.
Eli Lilly & Co.
Gilead Sciences Inc.
Johnson & Johnson
Merck & Co. Inc.
Pfizer Inc.
Regeneron Pharmaceuticals Inc.
Thermo Fisher Scientific Inc.

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

1 Economic profit. See details »

2 Invested capital. See details »

3 2024 Calculation
Economic spread ratio = 100 × Economic profit ÷ Invested capital
= 100 × ÷ =

4 Click competitor name to see calculations.


Economic Profit
The economic profit exhibits a fluctuating trend over the observed periods. Starting from a high value in 2020 at approximately 2.32 billion US dollars, it declines significantly in 2021 to about 1.43 billion US dollars. There is a partial recovery in 2022, with economic profit increasing to around 1.85 billion US dollars, followed by another decline in 2023 to roughly 1.50 billion US dollars. Notably, in 2024, the economic profit turns negative, reaching approximately -2.05 billion US dollars, indicating a considerable shift to economic loss.
Invested Capital
Invested capital demonstrates an overall increasing pattern from 2020 through 2023. Beginning at approximately 8.14 billion US dollars in 2020, it rises steadily to about 9.39 billion in 2021, then surges to approximately 13.18 billion in 2022 and further to 13.24 billion in 2023. However, in 2024 there is a substantial decrease to approximately 9.05 billion US dollars, signaling a significant reduction in capital investment or asset base during the final period.
Economic Spread Ratio
The economic spread ratio shows a consistent downward trend throughout the time series. Starting at a strong 28.54% in 2020, it drops to 15.26% in 2021 and continues declining to 14.05% in 2022 and 11.3% in 2023. By 2024, the ratio turns negative to -22.65%, which corresponds with the negative economic profit in the same year. This decline suggests diminishing returns on invested capital and worsening efficiency in generating economic profit over time.

Economic Profit Margin

Vertex Pharmaceuticals Inc., economic profit margin calculation, comparison to benchmarks

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Selected Financial Data (US$ in thousands)
Economic profit1
Revenues
Performance Ratio
Economic profit margin2
Benchmarks
Economic Profit Margin, Competitors3
AbbVie Inc.
Amgen Inc.
Bristol-Myers Squibb Co.
Danaher Corp.
Eli Lilly & Co.
Gilead Sciences Inc.
Johnson & Johnson
Merck & Co. Inc.
Pfizer Inc.
Regeneron Pharmaceuticals Inc.
Thermo Fisher Scientific Inc.

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

1 Economic profit. See details »

2 2024 Calculation
Economic profit margin = 100 × Economic profit ÷ Revenues
= 100 × ÷ =

3 Click competitor name to see calculations.


Revenues
Revenues demonstrate a consistent upward trend over the five-year period, increasing from approximately $6.21 billion in 2020 to $11.02 billion in 2024. This growth indicates strengthening business operations and market presence, with particularly notable increments between consecutive years, reflecting sustained expansion.
Economic Profit
Economic profit initially exhibits a strong positive performance with a peak of about $2.32 billion in 2020. However, there is a noticeable decline in 2021 to $1.43 billion, followed by a partial recovery in 2022, increasing to $1.85 billion. The value declines again in 2023 to approximately $1.50 billion, and then experiences a significant drop to a negative figure of around -$2.05 billion in 2024. This shift to a negative economic profit signals a deterioration in the company's value creation beyond its cost of capital in the latest period.
Economic Profit Margin
The economic profit margin, which relates economic profit to revenues, also follows a declining trajectory. Starting from a high of 37.45% in 2020, the margin falls sharply to 18.91% in 2021, and although it slightly recovers to 20.74% in 2022, it continues to decline thereafter. By 2023, the margin is reduced to 15.17%, and it turns negative at -18.59% in 2024. This negative margin at the end of the period highlights diminishing efficiency in generating economic profit relative to revenues.
Overall Analysis
Despite steadily increasing revenues, the company faces challenges in maintaining economic profitability, as evidenced by the volatility and eventual decline in economic profit and its margin. The negative economic profit and margin in 2024 suggest that costs, investments, or external factors may have adversely impacted profitability and value creation, warranting further examination of operational efficiency and cost structures. The divergence between rising revenues and decreasing economic profit underscores potential issues in translating top-line growth into sustainable financial performance.