Stock Analysis on Net

Vertex Pharmaceuticals Inc. (NASDAQ:VRTX)

$24.99

Income Statement

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Vertex Pharmaceuticals Inc., consolidated income statement

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2025 Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021
Product revenues, net
Other revenues
Revenues
Cost of sales
Gross profit
Research and development expenses
Acquired in-process research and development expenses
Selling, general and administrative expenses
Intangible asset impairment charge
Change in fair value of contingent consideration
Income (loss) from operations
Interest income
Interest expense
Other income (expense), net
Income before provision for income taxes
Provision for income taxes
Net income (loss)

Based on: 10-K (reporting date: 2025-12-31), 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31).


The financial performance presented demonstrates a generally positive trajectory in revenue and profitability, though with notable fluctuations, particularly in 2024. Product revenues, net, consistently increased from 2021 to 2025, growing from US$7,573.4 million to US$11,970.6 million. A small contribution from other revenues appears in 2025, reaching US$30.7 million. Overall revenues mirror this growth, increasing from US$7,574.4 million to US$12,001.3 million over the five-year period.

Cost of sales exhibited a steady increase throughout the period, rising from US$904.2 million in 2021 to US$1,651.3 million in 2025. This increase, while substantial in absolute terms, remained proportionally lower than the growth in revenues, resulting in expanding gross profit margins. Gross profit increased from US$6,670.2 million to US$10,350.0 million. However, operating income experienced significant volatility. While positive and growing from 2021 to 2023, it turned negative in 2024 before recovering strongly in 2025.

Operating Expenses
Research and development expenses consistently increased from US$1,937.8 million in 2021 to US$3,909.5 million in 2025, indicating a continued investment in innovation. Selling, general and administrative expenses also rose steadily, from US$840.1 million to US$1,753.1 million. A significant acquired in-process research and development expense was recorded in 2024 (US$4,628.4 million), contributing substantially to the operating loss in that year. An intangible asset impairment charge of US$379.0 million further impacted 2025 results.

Non-operating items showed fluctuations. Interest income increased significantly from 2021 to 2023, then stabilized. Interest expense decreased steadily over the period. Other income (expense), net, was volatile, with a large expense recorded in 2022. Income before provision for income taxes followed the trend of operating income, with a substantial dip in 2024 before a strong recovery in 2025.

Profitability
Net income mirrored the overall trend, increasing from US$2,342.1 million in 2021 to US$3,619.6 million in 2023, experiencing a net loss of US$535.6 million in 2024, and rebounding to a net income of US$3,953.2 million in 2025. The provision for income taxes remained relatively stable as a percentage of income before taxes, though the absolute amount varied with pre-tax income.

The year 2024 stands out as an anomaly, with a significant operating loss and net loss, primarily driven by the substantial acquired in-process research and development expense and intangible asset impairment charge. The recovery in 2025 suggests these were non-recurring items. Overall, the financial performance indicates a company with strong revenue growth and a commitment to research and development, though subject to potential volatility from large, infrequent charges.