Stock Analysis on Net

Vertex Pharmaceuticals Inc. (NASDAQ:VRTX)

$24.99

Analysis of Investments

Microsoft Excel

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Adjustment to Net Income (Loss): Mark to Market Available-for-sale Securities

Vertex Pharmaceuticals Inc., adjustment to net income (loss)

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Net income (loss) (as reported)
Add: Unrealized holding gains (losses) on marketable securities, net of tax
Net income (loss) (adjusted)

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).


The reported and adjusted net income of the company exhibit distinct trends over the five-year period under review.

Reported Net Income (Loss)
The reported net income shows an initial decrease from approximately 2.71 billion US dollars in 2020 to 2.34 billion US dollars in 2021. Following this decline, there is a significant increase in 2022, reaching around 3.32 billion US dollars, with further growth in 2023 to approximately 3.62 billion US dollars. However, in 2024, there is a notable reversal, with reported net income turning negative to a loss of approximately 536 million US dollars.
Adjusted Net Income (Loss)
The adjusted net income follows a nearly identical pattern to the reported net income. It decreases from approximately 2.71 billion US dollars in 2020 to 2.34 billion US dollars in 2021, then increases in 2022 to roughly 3.32 billion US dollars, and further rises in 2023 to about 3.63 billion US dollars. In 2024, the adjusted net income also turns negative, showing a loss of approximately 538 million US dollars.

The consistency between reported and adjusted net income figures indicates minimal differences between accounting methodologies over the period, suggesting that adjustments have a limited impact on the net income calculations.

Overall, the financial results show an upward trend in profitability from 2021 to 2023, followed by a substantial deterioration in 2024, which may signal operational challenges or extraordinary expenses in the latest period.


Adjusted Profitability Ratios: Mark to Market Available-for-sale Securities (Summary)

Vertex Pharmaceuticals Inc., adjusted profitability ratios

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
Net Profit Margin
Reported net profit margin
Adjusted net profit margin
Return on Equity (ROE)
Reported ROE
Adjusted ROE
Return on Assets (ROA)
Reported ROA
Adjusted ROA

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).


Net Profit Margin Trends
The reported net profit margin demonstrates a noticeable decline over the observed periods. Starting at a high of 43.7% in 2020, it dropped significantly to 30.92% in 2021, before partially recovering to 37.2% in 2022 and slightly decreasing to 36.68% in 2023. However, in 2024, it experienced a substantial downturn to -4.86%, indicating a shift from profitability to a loss. The adjusted net profit margin closely mirrors this trend, showing consistent alignment with the reported figures and confirming the significant negative turnaround in the latest period.
Return on Equity (ROE) Patterns
ROE follows a similarly downward trajectory. In 2020, the reported ROE was robust at 31.22%, but it declined steadily over the following years: 23.19% in 2021, 23.88% in 2022, and further down to 20.59% in 2023. The most notable change occurs in 2024, where reported ROE turns negative at -3.26%. Adjusted ROE values echo these movements with marginal differences, reinforcing the observation of deteriorating shareholder returns culminating in a negative outcome in the latest year.
Return on Assets (ROA) Developments
The reported ROA demonstrates a decline analogous to other profitability metrics, starting at 23.07% in 2020 and decreasing consistently to 17.44% in 2021, 18.3% in 2022, and 15.92% in 2023. A pronounced contraction to -2.38% in 2024 indicates a shift in asset efficiency towards negative returns. Adjusted ROA figures track reported values closely, confirming the reduced effectiveness in asset utilization by the most recent fiscal year.
Overall Insights
The data reveals a stable profitability and efficiency profile through the initial years, with peak margins and returns in 2020, followed by gradual declines in 2021 through 2023. The year 2024 marks a significant adverse inflection point, with all key financial performance indicators turning negative. This shift suggests fundamental challenges impacting profitability, equity returns, and asset utilization. The close alignment between reported and adjusted figures across all metrics underscores the reliability of this downward trend. Such a pattern warrants further investigation into operational, market, or structural issues contributing to this stark decline in financial performance.

Vertex Pharmaceuticals Inc., Profitability Ratios: Reported vs. Adjusted


Adjusted Net Profit Margin

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
As Reported
Selected Financial Data (US$ in thousands)
Net income (loss)
Revenues
Profitability Ratio
Net profit margin1
Adjusted: Mark to Market Available-for-sale Securities
Selected Financial Data (US$ in thousands)
Adjusted net income (loss)
Revenues
Profitability Ratio
Adjusted net profit margin2

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

2024 Calculations

1 Net profit margin = 100 × Net income (loss) ÷ Revenues
= 100 × ÷ =

2 Adjusted net profit margin = 100 × Adjusted net income (loss) ÷ Revenues
= 100 × ÷ =


The reported and adjusted net income data reveal significant fluctuations over the five-year period under review. Initially, both reported and adjusted net income values show a decline from 2020 to 2021, followed by a notable increase in 2022, reaching a peak in 2023. However, there is a sharp reversal in 2024, with net income turning negative, indicating a loss.

The reported net income decreased from approximately 2.71 billion US dollars in 2020 to about 2.34 billion in 2021. This was followed by a recovery to around 3.32 billion in 2022 and further growth to approximately 3.62 billion in 2023. In 2024, the net income shifted dramatically to a loss of approximately 536 million US dollars. The adjusted net income figures closely mirror this pattern, confirming consistency between reported and adjusted results.

Regarding profitability margins, both reported and adjusted net profit margins display a similar trend over the period. The margins started at a relatively high level of approximately 43.7% in 2020, then declined significantly to about 31% in 2021. In 2022, margins improved to around 37%, followed by a slight decrease but overall stability in 2023 near 36.7%. The year 2024 saw a steep drop to a negative margin close to -4.9%, reflecting the net loss reported during the same period.

Trends in net income and adjusted net income
Both metrics showed a decline during the early period (2020-2021), a strong recovery in the mid-period (2022-2023), and a substantial downturn resulting in losses in the final year (2024).
Net profit margin trends
Margins followed a pattern consistent with net income, indicating reduced profitability in 2021, subsequent recovery, and stability before a sharp negative reversal in 2024.
Comparability of reported versus adjusted data
The negligible differences between reported and adjusted figures suggest minimal reconciling items affecting net income and margin calculations over the timeframe, indicating reliability and consistency in the reported financial results.

Overall, the data reflect a volatile earnings pattern with positive growth phases interrupted by a significant downturn in the most recent period, warranting further investigation into the underlying causes, particularly for the loss recorded in 2024 and its impact on profitability.


Adjusted Return on Equity (ROE)

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
As Reported
Selected Financial Data (US$ in thousands)
Net income (loss)
Shareholders’ equity
Profitability Ratio
ROE1
Adjusted: Mark to Market Available-for-sale Securities
Selected Financial Data (US$ in thousands)
Adjusted net income (loss)
Shareholders’ equity
Profitability Ratio
Adjusted ROE2

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

2024 Calculations

1 ROE = 100 × Net income (loss) ÷ Shareholders’ equity
= 100 × ÷ =

2 Adjusted ROE = 100 × Adjusted net income (loss) ÷ Shareholders’ equity
= 100 × ÷ =


Net Income (Reported and Adjusted)
Reported net income demonstrated a fluctuating trajectory, beginning at approximately $2.71 billion in 2020 and declining to about $2.34 billion in 2021. Subsequently, it showed a significant increase to over $3.32 billion in 2022, followed by a further rise to nearly $3.62 billion in 2023. However, there was a sharp reversal in 2024, with reported net income turning negative to approximately -$536 million.
The adjusted net income followed a very similar pattern to the reported figures, indicating consistency between reported and adjusted earnings. It started at roughly $2.71 billion in 2020, decreased to about $2.34 billion in 2021, then increased substantially to $3.32 billion in 2022 and $3.63 billion in 2023, before falling sharply to about -$538 million in 2024.
Return on Equity (Reported and Adjusted)
Reported ROE exhibited a declining trend over the period. Starting at 31.22% in 2020, it decreased to 23.19% in 2021 and stabilized somewhat at 23.88% in 2022. The downward trend continued to 20.59% in 2023, followed by a significant decline to -3.26% in 2024, marking a transition into negative profitability from the shareholders’ perspective.
The adjusted ROE closely mirrored the reported ROE throughout the years, indicating negligible differences between the two metrics. It commenced at 31.21% in 2020, declined to 23.18% in 2021, then stabilized at 23.88% in 2022. After that, it decreased to 20.64% in 2023 before dropping sharply to -3.28% in 2024.
Overall Trends and Insights
The financial performance shows initial volatility with a dip in net income from 2020 to 2021, followed by recovery and growth in 2022 and 2023. However, 2024 marks a substantial downturn with a transition into negative net income and negative ROE, signaling significant operational or financial challenges. The close alignment between reported and adjusted figures suggests limited impact from accounting adjustments during this period.

Adjusted Return on Assets (ROA)

Microsoft Excel
Dec 31, 2024 Dec 31, 2023 Dec 31, 2022 Dec 31, 2021 Dec 31, 2020
As Reported
Selected Financial Data (US$ in thousands)
Net income (loss)
Total assets
Profitability Ratio
ROA1
Adjusted: Mark to Market Available-for-sale Securities
Selected Financial Data (US$ in thousands)
Adjusted net income (loss)
Total assets
Profitability Ratio
Adjusted ROA2

Based on: 10-K (reporting date: 2024-12-31), 10-K (reporting date: 2023-12-31), 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31).

2024 Calculations

1 ROA = 100 × Net income (loss) ÷ Total assets
= 100 × ÷ =

2 Adjusted ROA = 100 × Adjusted net income (loss) ÷ Total assets
= 100 × ÷ =


Net Income Trends
The reported net income displayed fluctuations over the time periods, initially showing a decrease from approximately 2.71 billion USD in 2020 to 2.34 billion USD in 2021. This was followed by a strong recovery and growth, reaching around 3.62 billion USD in 2023. However, in 2024, the net income sharply declined, turning negative to approximately -536 thousand USD, indicating a significant downturn. The adjusted net income closely mirrored this trend, demonstrating consistency between reported and adjusted figures with only minimal variances.
Return on Assets (ROA) Patterns
The reported ROA started at a high level of 23.07% in 2020 but saw a decline in the subsequent year to 17.44%. It then slightly increased to 18.3% in 2022 before declining again to 15.92% in 2023. By 2024, the ROA turned negative, registering -2.38%, which aligns with the negative net income observed in the same period. The adjusted ROA followed the same trajectory with negligible differences, showing a stable adjustment process.
Overall Financial Performance Insights
Overall, the financial data reveals a period of volatility with notable peaks in profitability around 2022 and 2023, followed by a marked deterioration in 2024. This could suggest episodic factors impacting profitability and asset utilization efficiency, which resulted in a loss during the last reported year. The consistency between reported and adjusted figures indicates that the adjustments made had minimal impact on the overall profitability and asset return measures.