|
3 months ended: |
Sep 30, 2020 |
|
Jun 30, 2020 |
|
Mar 31, 2020 |
|
Dec 31, 2019 |
|
Sep 30, 2019 |
|
Jun 30, 2019 |
|
Mar 31, 2019 |
|
Dec 31, 2018 |
|
Sep 30, 2018 |
|
Jun 30, 2018 |
|
Mar 31, 2018 |
|
Dec 31, 2017 |
|
Sep 30, 2017 |
|
Jun 30, 2017 |
|
Mar 31, 2017 |
|
Dec 31, 2016 |
|
Sep 30, 2016 |
|
Jun 30, 2016 |
|
Mar 31, 2016 |
|
Dec 31, 2015 |
|
Sep 30, 2015 |
|
Jun 30, 2015 |
|
Mar 31, 2015 |
|
|
Net income (loss) |
667,434 | |
837,270 | |
602,753 | |
583,234 | |
57,518 | |
267,427 | |
268,631 | |
1,525,096 | |
128,456 | |
206,250 | |
227,301 | |
102,185 | |
(291,267) | |
31,169 | |
249,548 | |
27,759 | |
(39,537) | |
(36,151) | |
(36,102) | |
(74,669) | |
(93,816) | |
(220,992) | |
(198,704) | |
|
Stock-based compensation expense |
99,539 | |
117,189 | |
115,706 | |
91,591 | |
85,420 | |
89,687 | |
93,791 | |
78,943 | |
85,532 | |
82,436 | |
78,136 | |
75,402 | |
73,770 | |
72,582 | |
68,982 | |
59,082 | |
61,209 | |
61,942 | |
55,472 | |
44,646 | |
65,734 | |
63,261 | |
57,384 | |
|
Depreciation expense |
26,642 | |
26,697 | |
26,821 | |
26,256 | |
25,847 | |
27,698 | |
27,140 | |
18,826 | |
19,192 | |
18,059 | |
16,343 | |
16,432 | |
15,225 | |
14,890 | |
14,850 | |
15,451 | |
14,569 | |
14,963 | |
16,415 | |
15,747 | |
16,168 | |
14,065 | |
16,363 | |
|
Increase in fair value of contingent consideration |
1,800 | |
9,200 | |
1,600 | |
1,500 | |
2,959 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Deferred income taxes |
56,147 | |
(27,742) | |
36,705 | |
73,212 | |
6,817 | |
43,933 | |
43,425 | |
(1,515,920) | |
79 | |
(71) | |
3,587 | |
(6,544) | |
(118,595) | |
3,414 | |
1,212 | |
(6,583) | |
686 | |
20,798 | |
2,060 | |
(4,510) | |
1,447 | |
6,346 | |
— | |
|
(Gains) losses on equity securities |
(75,750) | |
(109,986) | |
44,870 | |
(128,735) | |
31,216 | |
(56,527) | |
(43,551) | |
85,659 | |
61,159 | |
(53,918) | |
(95,458) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Intangible asset impairment charges |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
29,000 | |
— | |
— | |
— | |
— | |
255,340 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Acquired in-process research and development |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
160,000 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Deconsolidation of VIE |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
1,077 | |
— | |
— | |
— | |
— | |
76,644 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Other non-cash items, net |
36,064 | |
6,639 | |
9,668 | |
20,966 | |
(10,030) | |
8,437 | |
(2,431) | |
8,712 | |
6,848 | |
7,496 | |
9,446 | |
6,142 | |
1,706 | |
6,010 | |
581 | |
7,044 | |
(4,340) | |
7,271 | |
(3,835) | |
14,924 | |
(8,921) | |
5,416 | |
629 | |
|
Accounts receivable, net |
12,948 | |
59,533 | |
(223,672) | |
(184,143) | |
14,426 | |
(25,734) | |
(30,136) | |
(32,985) | |
12,999 | |
(74,693) | |
(13,473) | |
(17,304) | |
(13,005) | |
(36,332) | |
(5,118) | |
(23,267) | |
3,194 | |
(10,442) | |
(2,512) | |
(16,112) | |
(67,538) | |
(15,334) | |
(5,863) | |
|
Inventories |
(30,521) | |
(36,936) | |
(27,450) | |
(18,767) | |
(20,106) | |
(12,035) | |
(13,139) | |
(7,504) | |
(15,095) | |
(1,158) | |
(8,208) | |
(16,414) | |
(6,542) | |
(14,591) | |
(7,437) | |
(4,914) | |
(3,757) | |
(3,008) | |
(4,771) | |
(7,019) | |
(6,701) | |
(6,791) | |
(2,635) | |
|
Prepaid expenses and other assets |
(235,986) | |
(31,713) | |
2,790 | |
59,149 | |
(6,129) | |
(25,521) | |
7,941 | |
(15,113) | |
(1,611) | |
7,926 | |
25,482 | |
(21,057) | |
(42,158) | |
(670) | |
(47,178) | |
280 | |
(1,008) | |
(646) | |
(7,325) | |
14,477 | |
(8,340) | |
(164) | |
(15,233) | |
|
Accounts payable |
1,456 | |
412 | |
14,285 | |
(10,575) | |
15,864 | |
(3,929) | |
(24,145) | |
13,531 | |
10,794 | |
10,075 | |
2,154 | |
1,828 | |
(7,122) | |
13,330 | |
717 | |
9,787 | |
2,289 | |
(23,478) | |
(343) | |
(7,992) | |
9,316 | |
20,523 | |
(23,556) | |
|
Accrued expenses |
81,233 | |
216,037 | |
153,814 | |
(82,818) | |
141,731 | |
141,247 | |
(27,279) | |
125,256 | |
72,995 | |
119,301 | |
7,347 | |
86,841 | |
66,090 | |
91,851 | |
(10,465) | |
60,085 | |
32,351 | |
9,611 | |
(34,196) | |
49,651 | |
30,578 | |
23,404 | |
(50,621) | |
|
Other liabilities |
266,742 | |
(28,073) | |
57,808 | |
15,138 | |
(10,744) | |
9,066 | |
24,537 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Changes in operating assets and liabilities |
95,872 |
|
179,260 |
|
(22,425) |
|
(222,016) |
|
135,042 |
|
83,094 |
|
(62,221) |
|
83,185 |
|
80,082 |
|
61,451 |
|
13,302 |
|
33,894 |
|
(2,737) |
|
53,588 |
|
(69,481) |
|
41,971 |
|
33,069 |
|
(27,963) |
|
(49,147) |
|
33,005 |
|
(42,685) |
|
21,638 |
|
(97,908) |
|
|
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities |
240,314 |
|
201,257 |
|
212,945 |
|
(137,226) |
|
277,271 |
|
196,322 |
|
56,153 |
|
(1,210,518) |
|
252,892 |
|
115,453 |
|
25,356 |
|
125,326 |
|
461,353 |
|
150,484 |
|
16,144 |
|
116,965 |
|
105,193 |
|
77,011 |
|
20,965 |
|
103,812 |
|
31,743 |
|
110,726 |
|
(23,532) |
|
|
Net cash provided by (used in) operating activities |
907,748 |
|
1,038,527 |
|
815,698 |
|
446,008 |
|
334,789 |
|
463,749 |
|
324,784 |
|
314,578 |
|
381,348 |
|
321,703 |
|
252,657 |
|
227,511 |
|
170,086 |
|
181,653 |
|
265,692 |
|
144,724 |
|
65,656 |
|
40,860 |
|
(15,137) |
|
29,143 |
|
(62,073) |
|
(110,266) |
|
(222,236) |
|
|
Purchases of available-for-sale debt securities |
(120,360) | |
(51,312) | |
(75,265) | |
(155,457) | |
(118,103) | |
(135,421) | |
(128,215) | |
(102,551) | |
(127,365) | |
(163,349) | |
(38,653) | |
(100,928) | |
(53,986) | |
(129,394) | |
(248,273) | |
— | |
(146,548) | |
(245,453) | |
(224,624) | |
(340,906) | |
(166,480) | |
— | |
(125,655) | |
|
Maturities of available-for-sale debt securities |
39,024 | |
85,250 | |
60,145 | |
100,779 | |
146,438 | |
121,589 | |
107,118 | |
123,170 | |
137,378 | |
76,663 | |
94,365 | |
122,065 | |
78,267 | |
70,489 | |
98,393 | |
222,183 | |
203,063 | |
201,143 | |
131,173 | |
262,855 | |
62,863 | |
370,302 | |
371,423 | |
|
Sale of equity securities |
21,721 | |
55,838 | |
72,036 | |
94,936 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Payment to acquire business, net of cash acquired |
— | |
— | |
— | |
(908,388) | |
(245,824) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Expenditures for property and equipment |
(174,795) | |
(17,864) | |
(19,450) | |
(16,761) | |
(24,291) | |
(16,358) | |
(18,041) | |
(15,721) | |
(20,912) | |
(29,612) | |
(29,279) | |
(42,604) | |
(27,951) | |
(17,707) | |
(11,159) | |
(14,788) | |
(13,883) | |
(15,918) | |
(11,974) | |
(12,527) | |
(8,797) | |
(13,420) | |
(10,558) | |
|
Purchase of in-process research and development |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(160,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Investment in note receivable |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(15,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(20,000) | |
— | |
— | |
— | |
(30,000) | |
— | |
— | |
— | |
|
Investment in equity securities |
(13,527) | |
— | |
(5,800) | |
(12,100) | |
(7,219) | |
(20,000) | |
— | |
(22,981) | |
(38,990) | |
— | |
(21,500) | |
— | |
— | |
— | |
— | |
10,000 | |
(20,000) | |
(3,075) | |
— | |
— | |
— | |
— | |
— | |
|
Decrease in restricted cash due to deconsolidation of VIE |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(7,896) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Increase (decrease) in restricted cash and cash equivalents (VIE) |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
314 | |
1,222 | |
(20,063) | |
3,198 | |
10,658 | |
12,093 | |
5,760 | |
2,637 | |
(3,145) | |
12,553 | |
2,277 | |
— | |
|
Increase (decrease) in restricted cash and cash equivalents and other assets |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
56 | |
(8) | |
328 | |
60 | |
22,115 | |
66 | |
(239) | |
80 | |
1,033 | |
(1,074) | |
(716) | |
(21,172) | |
|
Payment for acquisition of variable interest entity |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(80,000) | |
— | |
|
Other investing activities |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
75 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Net cash (used in) provided by investing activities |
(247,937) |
|
71,912 |
|
31,666 |
|
(896,991) |
|
(248,999) |
|
(50,190) |
|
(39,138) |
|
(40,904) |
|
(49,889) |
|
(116,298) |
|
4,933 |
|
(21,097) |
|
(162,456) |
|
(96,347) |
|
(157,781) |
|
230,168 |
|
34,791 |
|
(57,782) |
|
(102,708) |
|
(122,690) |
|
(100,935) |
|
278,443 |
|
214,038 |
|
|
Issuances of common stock under benefit plans |
21,796 | |
133,461 | |
79,597 | |
198,614 | |
30,538 | |
50,472 | |
63,620 | |
43,539 | |
100,917 | |
56,434 | |
88,403 | |
46,635 | |
150,318 | |
136,638 | |
11,249 | |
17,065 | |
17,463 | |
24,856 | |
8,846 | |
45,903 | |
51,839 | |
46,234 | |
41,616 | |
|
Repurchases of common stock |
(108,007) | |
— | |
(300,026) | |
(36,062) | |
(104) | |
(56,010) | |
(99,839) | |
(143,005) | |
(92,005) | |
(105,033) | |
(10,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Payments in connection with common stock withheld for employee tax obligations |
(40,528) | |
(3,080) | |
(136,167) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Payments on finance leases |
(10,648) | |
(10,443) | |
(10,287) | |
(10,306) | |
(9,953) | |
(9,541) | |
(9,385) | |
(8,730) | |
(10,597) | |
(4,730) | |
(9,331) | |
(4,736) | |
(3,725) | |
(6,055) | |
(4,820) | |
(4,343) | |
(5,939) | |
(3,603) | |
(4,144) | |
(3,539) | |
(2,171) | |
(10,037) | |
(4,588) | |
|
Proceeds related to finance leases |
2,809 | |
— | |
5,833 | |
9,044 | |
— | |
1,002 | |
— | |
7,857 | |
3,417 | |
— | |
9,566 | |
29,966 | |
4,700 | |
— | |
— | |
9,178 | |
2,030 | |
— | |
— | |
10,276 | |
— | |
— | |
13,386 | |
|
Payments on revolving credit facility |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(300,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Advance from collaborator |
1,500 | |
1,000 | |
2,500 | |
2,500 | |
2,500 | |
2,500 | |
5,000 | |
— | |
2,500 | |
2,500 | |
2,500 | |
2,500 | |
2,500 | |
2,500 | |
5,000 | |
75,000 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Repayments of advanced funding |
(948) | |
(913) | |
(880) | |
(1,550) | |
(1,493) | |
(1,438) | |
(1,385) | |
(1,313) | |
(1,302) | |
(1,230) | |
(1,182) | |
(1,134) | |
(1,088) | |
(1,050) | |
(994) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Payments on senior secured term loan |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(75,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Proceeds from revolving credit facility |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
74,965 | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Payments of debt issuance costs |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
(3,103) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Other financing activities |
(6,658) | |
— | |
— | |
(819) | |
(1,132) | |
— | |
— | |
606 | |
(851) | |
851 | |
(1,000) | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
— | |
|
Net cash provided by (used in) financing activities |
(140,684) |
|
120,025 |
|
(359,430) |
|
161,421 |
|
20,356 |
|
(13,015) |
|
(41,989) |
|
(101,046) |
|
2,079 |
|
(51,208) |
|
78,956 |
|
73,231 |
|
152,705 |
|
132,033 |
|
(289,565) |
|
93,762 |
|
13,554 |
|
21,253 |
|
4,702 |
|
52,640 |
|
49,668 |
|
36,197 |
|
50,414 |
|
|
Effect of changes in exchange rates on cash |
6,158 | |
3,272 | |
(6,651) | |
5,652 | |
(3,201) | |
(430) | |
(378) | |
(1,426) | |
(555) | |
(5,857) | |
1,656 | |
801 | |
1,501 | |
2,112 | |
1,388 | |
(4,401) | |
(175) | |
(2,710) | |
2,620 | |
(575) | |
(953) | |
1,290 | |
(2,596) | |
|
Net increase (decrease) in cash and cash equivalents |
525,285 |
|
1,233,736 |
|
481,283 |
|
(283,910) |
|
102,945 |
|
400,114 |
|
243,279 |
|
171,202 |
|
332,983 |
|
148,340 |
|
338,202 |
|
280,446 |
|
161,836 |
|
219,451 |
|
(180,266) |
|
464,253 |
|
113,826 |
|
1,621 |
|
(110,523) |
|
(41,482) |
|
(114,293) |
|
205,664 |
|
39,620 |
|