Analysis of Profitability Ratios
Quarterly Data
Profitability ratios measure the company ability to generate profitable sales from its resources (assets).
Profitability Ratios (Summary)
Vertex Pharmaceuticals Inc., profitability ratios (quarterly data)
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
The analysis of the financial performance over the reviewed quarters reveals several notable trends in profitability and efficiency metrics.
- Gross Profit Margin
- The gross profit margin has shown a relatively stable trend, starting at approximately 88.06% and maintaining a high level throughout the periods. However, there is a gradual minor decline observed from 88.06% in early 2021 to around 86.03% - 86.28% in later quarters of 2025. This suggests a slight tightening in cost control or pressure on pricing strategies but overall indicates strong core profitability.
- Operating Profit Margin
- The operating profit margin exhibits more variability. Initially, it was around the mid-30% range in 2021, with an increase to nearly 49% in mid to late 2022. Afterwards, the margin decreased sharply in early 2024, even becoming negative in some quarters (approximately -3.37% to -6.69%). This significant decline points to increased operating expenses or disruptions affecting operational efficiency. However, by the end of 2025, the margin recovered somewhat to above 34%, indicating partial restoration of operational profitability.
- Net Profit Margin
- The net profit margin follows a somewhat parallel pattern to the operating margin, initially fluctuating around 30% in 2021, rising to nearly 40% in early 2023, and then sharply dropping to negative values in early 2024 (near -4.74% to -8.91%). The recovery trend is visible in late 2024 and 2025, with margins returning to about 31%. This pattern suggests the impact of extraordinary items or non-operational expenses contributing to net income volatility, alongside operational factors.
- Return on Equity (ROE)
- Return on equity started strong above 30% in early 2021 but declined to approximately 20-22% in subsequent periods, showing contraction in shareholder returns. Similar to other profitability ratios, ROE dropped into negative territory during early 2024, indicating a period of losses or diminished equity efficiency. Recovery to about 21% by 2025 signals improved profitability and effective use of equity capital thereafter.
- Return on Assets (ROA)
- The return on assets showed a reduction from 22.8% down to a range near 15-17% across most quarters, reflecting decreased asset utilization efficiency. ROA also turned negative concurrently with other metrics in early 2024, pointing to operational challenges impacting overall asset productivity. By the end of the period, a modest rebound back to approximately 15% is apparent, suggesting improved asset management post-challenges.
Overall, the data reflect strong profitability and efficiency performance through 2021 to early 2023, followed by a notable downturn in early 2024, marked by negative margins and returns. The subsequent partial recovery indicates efforts to address operational and financial issues. Despite the dip, the company maintained high gross profit margins throughout, underscoring sustained core product profitability.
Return on Sales
Return on Investment
Gross Profit Margin
Vertex Pharmaceuticals Inc., gross profit margin calculation (quarterly data)
| Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | Dec 31, 2021 | Sep 30, 2021 | Jun 30, 2021 | Mar 31, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in thousands) | |||||||||||||||||||||||||
| Gross profit | 2,661,600) | 2,557,200) | 2,407,200) | 2,488,600) | 2,379,300) | 2,273,700) | 2,348,000) | 2,149,700) | 2,164,800) | 2,184,600) | 2,107,900) | 2,019,400) | 2,044,900) | 1,934,400) | 1,851,700) | 1,825,174) | 1,747,652) | 1,565,398) | 1,531,976) | ||||||
| Revenues | 3,076,400) | 2,964,700) | 2,770,200) | 2,912,000) | 2,771,900) | 2,645,600) | 2,690,600) | 2,517,700) | 2,483,500) | 2,493,200) | 2,374,800) | 2,302,700) | 2,334,300) | 2,196,200) | 2,097,500) | 2,072,561) | 1,984,164) | 1,793,370) | 1,724,305) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Gross profit margin1 | 86.28% | 86.11% | 86.03% | 86.11% | 86.12% | 86.45% | 86.86% | 87.21% | 87.80% | 87.92% | 88.04% | 87.90% | 88.00% | 88.13% | 87.95% | 88.06% | 87.94% | 87.89% | 88.06% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Gross Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 69.74% | 70.93% | 70.69% | 69.99% | 67.21% | 62.75% | 62.28% | 62.42% | 65.76% | 68.91% | 69.43% | 70.00% | 69.62% | 70.48% | 69.53% | 68.96% | 67.72% | 65.62% | 64.82% | ||||||
| Amgen Inc. | 64.71% | 62.99% | 61.48% | 59.85% | 58.71% | 61.56% | 64.76% | 68.60% | 72.35% | 72.87% | 73.65% | 74.17% | 73.99% | 74.00% | 73.30% | 73.44% | 74.00% | 73.97% | 74.37% | ||||||
| Bristol-Myers Squibb Co. | 69.50% | 70.29% | 70.47% | 71.08% | 74.91% | 75.38% | 75.71% | 76.24% | 76.54% | 77.01% | 77.68% | 78.04% | 78.82% | 79.13% | 79.62% | 78.57% | 76.92% | 75.88% | 74.42% | ||||||
| Danaher Corp. | 59.53% | 59.66% | 59.74% | 59.50% | 59.37% | 59.27% | 58.39% | 58.74% | 58.77% | 59.17% | 60.22% | 60.21% | 60.65% | 60.77% | 60.77% | 60.95% | 60.44% | 59.24% | 57.60% | ||||||
| Eli Lilly & Co. | 83.03% | 82.64% | 81.70% | 81.31% | 80.91% | 80.75% | 80.16% | 79.25% | 78.67% | 77.77% | 77.67% | 76.77% | 75.61% | 75.98% | 74.40% | 74.18% | 74.85% | 74.27% | 75.88% | ||||||
| Gilead Sciences Inc. | — | 78.42% | 78.17% | 78.15% | 75.98% | 75.56% | 75.62% | 75.87% | 78.66% | 79.27% | 78.94% | 79.03% | 74.31% | 75.30% | 75.50% | 75.56% | 80.23% | 79.90% | 80.32% | ||||||
| Johnson & Johnson | 68.08% | 67.92% | 68.30% | 69.07% | 69.05% | 69.06% | 69.20% | 68.82% | 68.54% | 68.06% | 67.34% | 67.26% | 67.43% | 67.86% | 67.97% | 68.16% | 67.51% | 67.00% | 66.24% | ||||||
| Merck & Co. Inc. | 77.18% | 76.60% | 76.42% | 76.32% | 75.82% | 75.25% | 74.37% | 73.17% | 72.86% | 72.96% | 72.43% | 70.63% | 70.49% | 70.41% | 70.72% | 72.02% | 67.95% | 67.48% | 66.99% | ||||||
| Pfizer Inc. | 73.39% | 72.12% | 72.28% | 71.94% | 67.73% | 58.18% | 58.09% | 58.10% | 60.97% | 69.61% | 68.61% | 65.77% | 65.53% | 62.18% | 60.35% | 62.08% | 65.28% | 70.96% | 76.46% | ||||||
| Regeneron Pharmaceuticals Inc. | 85.39% | 85.57% | 85.79% | 86.13% | 86.12% | 86.16% | 86.32% | 86.16% | 85.96% | 86.42% | 86.96% | 87.18% | 85.39% | 84.97% | 84.65% | 84.83% | 86.65% | 86.85% | 86.84% | ||||||
| Thermo Fisher Scientific Inc. | 41.27% | 41.18% | 41.34% | 41.28% | 40.77% | 40.76% | 40.40% | 39.90% | 39.87% | 39.75% | 40.28% | 42.24% | 44.42% | 46.63% | 48.37% | 50.08% | 51.05% | 51.29% | 51.47% | ||||||
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
1 Q3 2025 Calculation
Gross profit margin = 100
× (Gross profitQ3 2025
+ Gross profitQ2 2025
+ Gross profitQ1 2025
+ Gross profitQ4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (2,661,600 + 2,557,200 + 2,407,200 + 2,488,600)
÷ (3,076,400 + 2,964,700 + 2,770,200 + 2,912,000)
= 86.28%
2 Click competitor name to see calculations.
- Revenue Trends
- Revenues exhibited a consistent upward trajectory from March 2021 through September 2025. Starting at approximately $1.72 billion, revenues increased steadily each quarter, reaching over $3.07 billion by the end of the period. This indicates sustained growth over multiple years with occasional minor fluctuations in certain quarters, such as a slight dip observed around December 2022 and March 2025, followed by continued recovery.
- Gross Profit Trends
- Gross profit also demonstrated a strong positive trend in line with revenues, rising from about $1.53 billion in March 2021 to approximately $2.66 billion by September 2025. The growth was relatively stable, with marginal declines in a few quarters, for example, a dip in December 2022 and again in March 2025. Nonetheless, the general pattern is one of sustained growth and improvement in gross profit levels reflecting increasing operational scale or efficiency.
- Gross Profit Margin
- The gross profit margin remained fairly stable throughout the timeframe, maintaining levels predominantly between approximately 86% and 88%. The margin started around 88% in early 2021, experienced a subtle decline toward the mid to late periods, dropping to a low near 86.1% by late 2024 and early 2025. However, the margin stabilized and slightly recovered to around 86.3% by the last observed quarter. This suggests that while revenues and gross profits increased substantially, the proportion of profits relative to revenue showed a modest reduction in efficiency or margin pressure toward the later quarters, though overall profitability remained strong.
- Overall Financial Insights
- The data reflects a robust financial performance marked by continuous revenue and gross profit growth over nearly five years. Despite minor fluctuations and moderate compression in gross profit margin percentage, the company maintained high profitability levels throughout. The steady increases in revenue and gross profit imply effective business scaling and possibly improved market penetration or product demand. The slight decline in gross profit margin suggests possible increased costs or pricing pressures, but the margin remained predominantly high, supporting a solid financial foundation.
Operating Profit Margin
Vertex Pharmaceuticals Inc., operating profit margin calculation (quarterly data)
| Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | Dec 31, 2021 | Sep 30, 2021 | Jun 30, 2021 | Mar 31, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in thousands) | |||||||||||||||||||||||||
| Income (loss) from operations | 1,186,200) | 1,151,100) | 630,100) | 1,026,000) | 1,116,300) | (3,514,700) | 1,139,500) | 988,500) | 1,038,100) | 1,026,400) | 779,000) | 1,033,500) | 1,126,700) | 1,106,300) | 1,040,900) | 877,723) | 1,054,512) | (37,961) | 887,826) | ||||||
| Revenues | 3,076,400) | 2,964,700) | 2,770,200) | 2,912,000) | 2,771,900) | 2,645,600) | 2,690,600) | 2,517,700) | 2,483,500) | 2,493,200) | 2,374,800) | 2,302,700) | 2,334,300) | 2,196,200) | 2,097,500) | 2,072,561) | 1,984,164) | 1,793,370) | 1,724,305) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Operating profit margin1 | 34.06% | 34.36% | -6.69% | -2.11% | -2.54% | -3.37% | 41.16% | 38.83% | 40.16% | 41.72% | 43.93% | 48.23% | 47.72% | 48.85% | 36.93% | 36.73% | 37.17% | 33.93% | 47.14% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Operating Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 15.16% | 18.80% | 17.56% | 16.22% | 24.89% | 22.31% | 23.50% | 23.49% | 27.32% | 31.03% | 28.49% | 31.21% | 30.59% | 30.33% | 32.68% | 31.89% | 30.09% | 28.95% | 23.63% | ||||||
| Amgen Inc. | 25.14% | 24.45% | 22.71% | 22.66% | 19.97% | 20.96% | 24.72% | 29.35% | 34.55% | 37.50% | 36.07% | 38.57% | 39.31% | 38.04% | 32.78% | 31.44% | 30.14% | 30.72% | 37.23% | ||||||
| Bristol-Myers Squibb Co. | 18.86% | 16.70% | 15.24% | -15.50% | -14.05% | -14.39% | -14.30% | 16.18% | 16.96% | 17.29% | 18.13% | 17.96% | 19.04% | 18.19% | 16.79% | 15.91% | -15.73% | -17.02% | -19.19% | ||||||
| Danaher Corp. | 19.01% | 18.39% | 20.26% | 20.37% | 20.11% | 21.22% | 21.05% | 21.77% | 23.83% | 25.06% | 27.02% | 27.61% | 27.35% | 25.44% | 25.23% | 25.35% | 24.63% | 25.04% | 22.30% | ||||||
| Eli Lilly & Co. | 38.84% | 32.37% | 28.74% | 28.64% | 24.81% | 23.28% | 20.80% | 18.92% | 18.42% | 24.17% | 22.45% | 24.97% | 24.65% | 25.50% | 25.94% | 22.45% | 23.17% | 21.81% | 22.06% | ||||||
| Gilead Sciences Inc. | — | 28.03% | 28.77% | 5.81% | 2.92% | 9.26% | 5.79% | 28.24% | 30.37% | 31.18% | 33.03% | 27.17% | 22.39% | 25.78% | 26.56% | 36.72% | 42.79% | 37.20% | 18.07% | ||||||
| Johnson & Johnson | 25.44% | 23.67% | 23.59% | 23.42% | 24.42% | 25.31% | 25.04% | 24.90% | 25.55% | 25.61% | 25.21% | 24.63% | 23.89% | 23.47% | 23.76% | 24.95% | 24.69% | 25.23% | 24.10% | ||||||
| Merck & Co. Inc. | 33.73% | 30.00% | 31.51% | 31.03% | 21.60% | 24.75% | 6.93% | 3.92% | 13.08% | 10.34% | 27.85% | 30.27% | 30.66% | 33.04% | 28.85% | 25.74% | 14.07% | 10.64% | 14.02% | ||||||
| Pfizer Inc. | 21.85% | 23.23% | 19.29% | 19.51% | 9.56% | -4.19% | -2.08% | 2.15% | 14.36% | 28.13% | 34.44% | 34.83% | 33.59% | 30.37% | 26.12% | 23.91% | 24.67% | 24.12% | 21.20% | ||||||
| Regeneron Pharmaceuticals Inc. | 25.89% | 27.02% | 27.20% | 28.10% | 28.69% | 28.95% | 29.40% | 30.85% | 32.23% | 34.20% | 35.79% | 38.93% | 45.45% | 48.19% | 55.08% | 55.67% | 55.19% | 53.94% | 43.37% | ||||||
| Thermo Fisher Scientific Inc. | 17.16% | 17.13% | 17.23% | 17.11% | 16.93% | 17.01% | 16.38% | 16.00% | 15.81% | 15.42% | 16.29% | 18.69% | 20.54% | 22.51% | 23.83% | 25.57% | 27.04% | 28.00% | 27.68% | ||||||
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
1 Q3 2025 Calculation
Operating profit margin = 100
× (Income (loss) from operationsQ3 2025
+ Income (loss) from operationsQ2 2025
+ Income (loss) from operationsQ1 2025
+ Income (loss) from operationsQ4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (1,186,200 + 1,151,100 + 630,100 + 1,026,000)
÷ (3,076,400 + 2,964,700 + 2,770,200 + 2,912,000)
= 34.06%
2 Click competitor name to see calculations.
- Income (loss) from operations
- Over the observed periods, the income from operations exhibited significant volatility. Initially, there was a strong positive figure of approximately 888 million USD, followed by a sharp decline to a loss of around 38 million USD in the subsequent quarter. This was succeeded by a recovery phase, with income consistently exceeding 1 billion USD through most of 2021 and 2022. However, at the beginning of 2024, there was a notable and substantial loss, peaking at about 3.5 billion USD negative, before bouncing back to positive earnings in the following quarters. Toward the end of the timeframe, income from operations stabilized in the range of 600 million to 1.2 billion USD, indicating a return to operational profitability after the earlier large loss.
- Revenues
- Revenues demonstrated a generally upward trend throughout the entire period. Starting from approximately 1.72 billion USD in early 2021, revenues grew steadily quarter-over-quarter, with only minor fluctuations. The growth accelerated as revenues approached nearly 3.08 billion USD by late 2025. This persistent increase suggests strong sales momentum and expansion in business scale, despite the occasional operational setbacks reflected in the operating income.
- Operating profit margin
- The operating profit margin showed a pattern of fluctuation aligned with the income trends. During 2021 and 2022, margins remained robust, often above 35%, peaking close to 49% in mid-2022. In early 2024, a sharp decrease is evident, with margins turning negative to around -3% to -6.7%, reflecting the operational losses reported during the same period. Following this downturn, margins recovered significantly in the last quarters, stabilizing in the mid-30% range, which corresponds with resumed profitability.
- Overall Analysis
- Throughout the timeline, the company experienced notable growth in revenue, indicating consistent business expansion and market demand. Despite this, operational profitability was uneven, marked by periods of strong gains and significant losses. The pronounced operational losses in early 2024 suggest extraordinary or non-recurring events impacting earnings. However, the subsequent recovery in operations income and a rebound in operating profit margins by late 2024 and into 2025 illustrate resilience and a return to effective cost management or revenue strength. The company's ability to maintain upward revenue trends alongside fluctuating profitability highlights areas for further investigation, particularly regarding expense control, cost structure, or one-time impairments.
Net Profit Margin
Vertex Pharmaceuticals Inc., net profit margin calculation (quarterly data)
| Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | Dec 31, 2021 | Sep 30, 2021 | Jun 30, 2021 | Mar 31, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in thousands) | |||||||||||||||||||||||||
| Net income (loss) | 1,082,900) | 1,032,900) | 646,300) | 913,000) | 1,045,400) | (3,593,600) | 1,099,600) | 968,800) | 1,035,300) | 915,700) | 699,800) | 818,900) | 930,500) | 810,500) | 762,100) | 770,110) | 851,928) | 66,924) | 653,138) | ||||||
| Revenues | 3,076,400) | 2,964,700) | 2,770,200) | 2,912,000) | 2,771,900) | 2,645,600) | 2,690,600) | 2,517,700) | 2,483,500) | 2,493,200) | 2,374,800) | 2,302,700) | 2,334,300) | 2,196,200) | 2,097,500) | 2,072,561) | 1,984,164) | 1,793,370) | 1,724,305) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Net profit margin1 | 31.35% | 31.86% | -8.91% | -4.86% | -4.52% | -4.74% | 39.46% | 36.68% | 35.94% | 35.40% | 35.40% | 37.20% | 37.62% | 38.26% | 30.84% | 30.92% | 30.52% | 29.80% | 43.06% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Net Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 4.00% | 6.45% | 7.31% | 7.59% | 9.22% | 9.71% | 11.02% | 8.95% | 11.81% | 15.50% | 13.37% | 20.39% | 23.19% | 22.04% | 22.00% | 20.54% | 13.66% | 12.40% | 10.28% | ||||||
| Amgen Inc. | 20.31% | 19.75% | 18.10% | 12.77% | 13.58% | 10.60% | 13.35% | 24.96% | 29.52% | 31.52% | 31.77% | 26.42% | 27.88% | 26.73% | 23.42% | 24.25% | 23.03% | 23.80% | 29.60% | ||||||
| Bristol-Myers Squibb Co. | 12.57% | 10.58% | 11.38% | -18.53% | -15.30% | -14.06% | -13.50% | 17.83% | 18.44% | 17.62% | 15.95% | 13.71% | 14.29% | 14.04% | 13.31% | 15.08% | -11.89% | -11.44% | -14.53% | ||||||
| Danaher Corp. | 14.43% | 14.21% | 15.81% | 16.33% | 16.39% | 17.83% | 18.54% | 19.94% | 22.89% | 22.80% | 23.32% | 22.91% | 21.65% | 20.61% | 21.32% | 21.84% | 20.97% | 21.00% | 19.17% | ||||||
| Eli Lilly & Co. | 30.99% | 25.91% | 22.66% | 23.51% | 20.48% | 18.86% | 17.08% | 15.36% | 15.55% | 22.01% | 20.54% | 21.88% | 20.63% | 19.58% | 20.90% | 19.71% | 21.52% | 22.71% | 23.91% | ||||||
| Gilead Sciences Inc. | — | 21.98% | 20.87% | 1.68% | 0.45% | 3.82% | 1.78% | 21.03% | 21.60% | 20.18% | 20.87% | 17.02% | 12.44% | 15.22% | 16.60% | 23.05% | 27.21% | 19.62% | 1.19% | ||||||
| Johnson & Johnson | 27.26% | 25.00% | 24.41% | 15.84% | 16.74% | 43.91% | 44.92% | 41.28% | 39.58% | 14.52% | 13.77% | 18.90% | 19.95% | 19.21% | 20.90% | 22.26% | 19.55% | 19.92% | 17.95% | ||||||
| Merck & Co. Inc. | 29.63% | 25.79% | 27.27% | 26.68% | 19.23% | 21.98% | 3.76% | 0.61% | 7.77% | 5.34% | 22.52% | 24.49% | 25.88% | 29.00% | 26.27% | 26.79% | 15.09% | 11.83% | 15.09% | ||||||
| Pfizer Inc. | 15.65% | 16.84% | 12.62% | 12.62% | 7.04% | -4.62% | -0.55% | 3.56% | 15.13% | 27.38% | 31.19% | 31.27% | 29.81% | 28.94% | 27.01% | 27.04% | 28.77% | 23.86% | 24.03% | ||||||
| Regeneron Pharmaceuticals Inc. | 32.13% | 31.37% | 31.94% | 31.07% | 33.61% | 32.04% | 29.45% | 30.14% | 30.47% | 33.93% | 33.81% | 35.64% | 39.17% | 39.97% | 48.06% | 50.25% | 51.65% | 50.11% | 43.53% | ||||||
| Thermo Fisher Scientific Inc. | 15.02% | 15.23% | 15.18% | 14.77% | 14.48% | 14.69% | 14.20% | 13.99% | 13.68% | 13.14% | 13.75% | 15.47% | 15.92% | 17.37% | 18.49% | 19.70% | 21.93% | 22.47% | 22.08% | ||||||
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
1 Q3 2025 Calculation
Net profit margin = 100
× (Net income (loss)Q3 2025
+ Net income (loss)Q2 2025
+ Net income (loss)Q1 2025
+ Net income (loss)Q4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (1,082,900 + 1,032,900 + 646,300 + 913,000)
÷ (3,076,400 + 2,964,700 + 2,770,200 + 2,912,000)
= 31.35%
2 Click competitor name to see calculations.
The financial performance exhibits notable fluctuations over the reported periods. Revenues demonstrate an overall upward trend, increasing from approximately $1.72 billion in the first quarter of 2021 to around $3.08 billion by the third quarter of 2025. This steady growth highlights expanding sales or service provision capacity over time.
Net income figures show considerable variability. Initial quarters, including early 2021, display strong positive net income, peaking at values near $851 million in the third quarter of 2021. Positive net income persists through several subsequent quarters, with occasional moderate declines. However, a significant negative deviation appears in the second quarter of 2024, where net income records a substantial loss exceeding $3.59 billion. Despite this exceptional loss, net income recovers in following quarters, returning to positive territory and maintaining values above $600 million through to late 2025.
The net profit margin percentage generally aligns with the net income trend, with margins fluctuating between roughly 30% and 39% in most quarters from 2021 to early 2024, indicating a relatively healthy profitability level relative to revenues. The margin sharply deteriorates during the major loss period in 2024, turning negative and bottoming near -8.91%. Following this downturn, margins rebound, returning to positive figures above 30% in subsequent quarters, consistent with the recovery in net income.
- Revenues
- Exhibit continuous growth over the entire period, suggesting successful market expansion or increased demand.
- Net Income
- Generally positive with high volatility, includes an extraordinary loss event in mid-2024, followed by a quick recovery to prior profitability levels.
- Net Profit Margin
- Follows income trends closely, maintaining strong profitability outside of the loss period, indicating overall operational efficiency.
Overall, the data indicate sustained revenue growth supporting profitable operations, despite a significant loss impacting margins temporarily. Post-loss recovery reveals resilience in maintaining profitability levels consistent with historical performance.
Return on Equity (ROE)
Vertex Pharmaceuticals Inc., ROE calculation (quarterly data)
| Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | Dec 31, 2021 | Sep 30, 2021 | Jun 30, 2021 | Mar 31, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in thousands) | |||||||||||||||||||||||||
| Net income (loss) | 1,082,900) | 1,032,900) | 646,300) | 913,000) | 1,045,400) | (3,593,600) | 1,099,600) | 968,800) | 1,035,300) | 915,700) | 699,800) | 818,900) | 930,500) | 810,500) | 762,100) | 770,110) | 851,928) | 66,924) | 653,138) | ||||||
| Shareholders’ equity | 17,318,800) | 17,175,400) | 16,496,300) | 16,409,600) | 15,630,900) | 14,774,700) | 18,546,600) | 17,580,400) | 16,512,800) | 15,470,200) | 14,432,300) | 13,912,700) | 13,029,600) | 11,933,500) | 10,907,000) | 10,100,000) | 9,530,708) | 9,196,396) | 8,980,254) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROE1 | 21.22% | 21.18% | -5.99% | -3.26% | -3.07% | -3.32% | 21.67% | 20.59% | 21.01% | 21.75% | 22.59% | 23.88% | 25.12% | 26.77% | 22.47% | 23.19% | 22.83% | 21.66% | 30.76% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROE, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | — | — | 295.42% | 128.66% | 84.91% | 78.77% | 74.85% | 46.94% | 53.86% | 67.50% | 57.14% | 68.60% | 83.83% | 86.24% | 76.64% | 74.91% | 55.60% | 53.01% | 37.63% | ||||||
| Amgen Inc. | 72.82% | 89.11% | 95.59% | 69.59% | 56.20% | 52.83% | 74.93% | 107.78% | 98.82% | 117.67% | 148.04% | 178.97% | 187.11% | 271.85% | 624.78% | 87.96% | 68.26% | 69.67% | 75.91% | ||||||
| Bristol-Myers Squibb Co. | 32.55% | 28.96% | 31.16% | -54.78% | -42.34% | -38.44% | -37.28% | 27.27% | 28.57% | 24.91% | 22.97% | 20.37% | 20.44% | 20.30% | 19.79% | 19.46% | -14.52% | -13.80% | -16.54% | ||||||
| Danaher Corp. | 6.86% | 6.52% | 7.40% | 7.87% | 7.59% | 8.42% | 8.24% | 8.91% | 11.29% | 12.30% | 13.47% | 14.39% | 14.40% | 13.63% | 13.93% | 14.24% | 13.54% | 13.12% | 11.76% | ||||||
| Eli Lilly & Co. | 77.38% | 75.52% | 70.45% | 74.62% | 58.78% | 54.14% | 47.91% | 48.65% | 44.46% | 58.73% | 50.82% | 58.64% | 59.91% | 66.61% | 65.69% | 62.16% | 76.99% | 94.20% | 88.31% | ||||||
| Gilead Sciences Inc. | — | 32.08% | 31.13% | 2.48% | 0.69% | 5.77% | 2.77% | 24.81% | 26.33% | 25.92% | 26.59% | 21.62% | 15.82% | 20.44% | 22.66% | 29.55% | 34.44% | 26.20% | 1.59% | ||||||
| Johnson & Johnson | 31.69% | 28.88% | 27.92% | 19.68% | 20.93% | 53.14% | 54.95% | 51.11% | 48.61% | 17.37% | 17.95% | 23.36% | 25.68% | 24.05% | 26.54% | 28.20% | 25.44% | 25.53% | 22.96% | ||||||
| Merck & Co. Inc. | 36.71% | 33.49% | 36.07% | 36.96% | 27.30% | 31.52% | 5.71% | 0.97% | 11.17% | 8.04% | 27.82% | 31.57% | 34.32% | 38.34% | 34.68% | 34.17% | 20.10% | 16.73% | 26.08% | ||||||
| Pfizer Inc. | 10.59% | 12.12% | 8.73% | 9.11% | 4.61% | -2.96% | -0.33% | 2.38% | 10.81% | 21.68% | 28.77% | 32.79% | 32.14% | 33.61% | 30.29% | 28.47% | 26.28% | 18.86% | 16.23% | ||||||
| Regeneron Pharmaceuticals Inc. | 14.79% | 14.89% | 15.31% | 15.03% | 15.87% | 15.32% | 14.29% | 15.22% | 16.03% | 17.90% | 17.80% | 19.14% | 25.05% | 27.49% | 39.84% | 43.03% | 40.53% | 41.02% | 33.43% | ||||||
| Thermo Fisher Scientific Inc. | 12.88% | 13.03% | 13.19% | 12.78% | 12.52% | 13.12% | 13.26% | 12.83% | 13.11% | 13.08% | 14.26% | 15.80% | 16.15% | 17.59% | 18.56% | 18.94% | 22.13% | 23.32% | 22.60% | ||||||
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
1 Q3 2025 Calculation
ROE = 100
× (Net income (loss)Q3 2025
+ Net income (loss)Q2 2025
+ Net income (loss)Q1 2025
+ Net income (loss)Q4 2024)
÷ Shareholders’ equity
= 100 × (1,082,900 + 1,032,900 + 646,300 + 913,000)
÷ 17,318,800 = 21.22%
2 Click competitor name to see calculations.
The analysis of the quarterly financial data reveals several key trends and notable fluctuations over the observed periods.
- Net Income (Loss)
- The net income exhibited considerable variability throughout the quarters. Initially, the company reported positive net income values with figures ranging from approximately 65 million to over 930 million US dollars. However, a significant anomaly occurred in the quarter ending June 30, 2024, where the net income turned sharply negative, recording a loss exceeding 3.5 billion US dollars. Following this loss, the net income quickly reverted to positive territory and stabilized, with subsequent quarters reflecting amounts generally in the range of 600 million to over 1 billion US dollars. This pattern indicates a temporary, yet substantial, adverse financial event followed by recovery.
- Shareholders’ Equity
- Shareholders’ equity demonstrated a steady upward trend from March 31, 2021, through December 31, 2023, increasing from approximately 8.98 billion to around 17.58 billion US dollars. This growth reflects consistent value addition to the equity base over multiple quarters. However, there was a notable decline in the quarter ending June 30, 2024, where equity decreased to approximately 14.77 billion. After this dip, shareholders’ equity resumed its upward trajectory, reaching about 17.32 billion by the quarter ending September 30, 2025. The temporary decline coincides with the period of the significant net loss, suggesting a possible impairment or write-down impacting equity.
- Return on Equity (ROE)
- ROE values predominantly remained strong and positive, mostly fluctuating between 20% and 30%, indicating effective utilization of equity to generate profits across the majority of the periods. This trend is consistent with the positive net income figures observed in those quarters. The quarters ending March 31, 2024, through December 31, 2024, exhibited negative ROE values ranging from approximately -3% to nearly -6%, corresponding with the period of net loss and decline in shareholders’ equity. Post this period, ROE rebounded to positive levels around 21%, signaling a recovery in profitability relative to shareholders’ equity once again.
Overall, the financial data indicates sustained growth in shareholders’ equity and robust profitability under normal conditions, disrupted temporarily by a considerable financial setback mid-2024. The company's ability to return to positive net income and restore ROE to typical levels within subsequent quarters suggests resilience and effective management response to the adverse event.
Return on Assets (ROA)
Vertex Pharmaceuticals Inc., ROA calculation (quarterly data)
| Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | Dec 31, 2021 | Sep 30, 2021 | Jun 30, 2021 | Mar 31, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in thousands) | |||||||||||||||||||||||||
| Net income (loss) | 1,082,900) | 1,032,900) | 646,300) | 913,000) | 1,045,400) | (3,593,600) | 1,099,600) | 968,800) | 1,035,300) | 915,700) | 699,800) | 818,900) | 930,500) | 810,500) | 762,100) | 770,110) | 851,928) | 66,924) | 653,138) | ||||||
| Total assets | 24,862,300) | 24,036,700) | 22,880,500) | 22,533,200) | 22,240,200) | 20,132,100) | 23,917,400) | 22,730,200) | 21,726,200) | 20,349,200) | 18,974,200) | 18,150,900) | 16,706,400) | 15,582,200) | 14,256,100) | 13,432,500) | 12,618,745) | 12,221,686) | 12,115,059) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROA1 | 14.78% | 15.13% | -4.32% | -2.38% | -2.16% | -2.43% | 16.81% | 15.92% | 15.97% | 16.54% | 17.18% | 18.30% | 19.59% | 20.50% | 17.19% | 17.44% | 17.25% | 16.30% | 22.80% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROA, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 1.78% | 2.74% | 3.08% | 3.17% | 3.57% | 3.76% | 4.03% | 3.61% | 4.78% | 6.42% | 5.64% | 8.53% | 9.49% | 8.83% | 8.71% | 7.88% | 5.06% | 4.50% | 3.43% | ||||||
| Amgen Inc. | 7.77% | 7.53% | 6.64% | 4.45% | 4.65% | 3.44% | 4.05% | 6.91% | 8.36% | 8.84% | 8.92% | 10.06% | 10.73% | 11.09% | 9.67% | 9.63% | 8.63% | 9.61% | 11.33% | ||||||
| Bristol-Myers Squibb Co. | 6.23% | 5.33% | 5.86% | -9.66% | -7.75% | -6.91% | -6.21% | 8.43% | 9.08% | 8.52% | 7.75% | 6.53% | 6.80% | 6.59% | 6.07% | 6.40% | -4.87% | -4.58% | -5.53% | ||||||
| Danaher Corp. | 4.38% | 4.18% | 4.76% | 5.03% | 4.83% | 5.35% | 5.28% | 5.64% | 6.74% | 7.49% | 8.15% | 8.55% | 8.35% | 7.76% | 7.74% | 7.73% | 7.13% | 7.19% | 6.30% | ||||||
| Eli Lilly & Co. | 16.02% | 13.67% | 12.42% | 13.45% | 11.07% | 10.22% | 9.60% | 8.19% | 8.61% | 11.85% | 10.70% | 12.62% | 12.71% | 12.09% | 13.06% | 11.44% | 12.39% | 12.70% | 13.01% | ||||||
| Gilead Sciences Inc. | — | 11.33% | 10.57% | 0.81% | 0.23% | 1.97% | 0.86% | 9.12% | 9.42% | 8.80% | 9.02% | 7.27% | 5.33% | 6.58% | 7.16% | 9.16% | 11.02% | 7.59% | 0.45% | ||||||
| Johnson & Johnson | 13.03% | 11.72% | 11.26% | 7.81% | 8.24% | 20.99% | 22.37% | 20.98% | 20.85% | 6.81% | 6.49% | 9.57% | 10.94% | 10.33% | 11.12% | 11.47% | 9.98% | 10.07% | 8.76% | ||||||
| Merck & Co. Inc. | 14.69% | 13.96% | 15.14% | 14.62% | 10.34% | 12.20% | 2.18% | 0.34% | 4.32% | 2.98% | 12.09% | 13.30% | 14.25% | 15.48% | 13.29% | 12.35% | 7.70% | 6.14% | 7.73% | ||||||
| Pfizer Inc. | 4.71% | 5.22% | 3.79% | 3.76% | 1.94% | -1.20% | -0.14% | 0.94% | 4.87% | 9.75% | 14.85% | 15.91% | 15.32% | 15.01% | 13.58% | 12.11% | 11.10% | 7.78% | 7.01% | ||||||
| Regeneron Pharmaceuticals Inc. | 11.40% | 11.67% | 11.98% | 11.69% | 12.43% | 11.98% | 11.22% | 11.95% | 12.41% | 14.02% | 13.91% | 14.85% | 19.40% | 20.90% | 30.11% | 31.75% | 29.55% | 28.88% | 22.53% | ||||||
| Thermo Fisher Scientific Inc. | 6.38% | 6.50% | 6.58% | 6.51% | 6.11% | 6.32% | 6.21% | 6.07% | 6.12% | 6.08% | 6.36% | 7.15% | 7.77% | 8.21% | 8.20% | 8.12% | 11.64% | 12.70% | 12.02% | ||||||
Based on: 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-09-30), 10-Q (reporting date: 2021-06-30), 10-Q (reporting date: 2021-03-31).
1 Q3 2025 Calculation
ROA = 100
× (Net income (loss)Q3 2025
+ Net income (loss)Q2 2025
+ Net income (loss)Q1 2025
+ Net income (loss)Q4 2024)
÷ Total assets
= 100 × (1,082,900 + 1,032,900 + 646,300 + 913,000)
÷ 24,862,300 = 14.78%
2 Click competitor name to see calculations.
- Net Income (Loss)
- The net income figures demonstrate significant volatility over the observed periods. Initial quarters from 2021 to early 2024 predominantly show robust and positive net income, with peaks reaching over 1 billion US dollars in some quarters. A notable exception occurs in the first half of 2024, where there is a substantial net loss of approximately 3.6 billion US dollars reported in the March 31, 2024 quarter, indicating a possible one-time charge or significant event adversely impacting earnings. Following this loss, net income returns to positive territory, fluctuating but generally maintaining a level between 600 million and 1.1 billion US dollars in subsequent quarters.
- Total Assets
- Total assets demonstrate an upward trajectory across the entire period, rising from approximately 12.1 billion US dollars in early 2021 to about 24.9 billion US dollars by the first quarter of 2025. This steady increase suggests consistent asset growth, possibly from investments, acquisitions, or retained earnings. An interruption is observed in mid-2024 where assets decline from 23.9 billion to 20.1 billion, coinciding with the quarter of large net loss, indicating a potential asset write-down or disposal.
- Return on Assets (ROA)
- The ROA values initially reflect solid profitability, ranging between roughly 16% to 23% during early 2021. This level of return remains relatively stable until early 2024, after which there is a sharp decline to negative values around -2% to -4% during the quarters with substantial losses. As net income recovers in later quarters, ROA also improves, returning to positive levels near 15%, though not reaching the higher levels seen in 2021 and 2022. This pattern highlights a period of significant operational or financial distress followed by partial recovery.
- Overall Financial Trends
- Across the examined span, the financial data indicates a generally strong performance in the initial years with consistent growth in both net income and total assets, complemented by high returns on assets. The period around early 2024, however, marks an abnormal disruption characterized by a major net loss and asset decline, negatively affecting profitability metrics. The company appears to stabilize and recover in the later quarters, though profitability metrics have not fully returned to their earlier peak levels. This suggests resilience but also warns of past volatility that may impact future financial planning and risk assessment.