Analysis of Profitability Ratios
Quarterly Data
Profitability ratios measure the company ability to generate profitable sales from its resources (assets).
Profitability Ratios (Summary)
Eli Lilly & Co., profitability ratios (quarterly data)
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
The financial performance across the analyzed period demonstrates a significant trajectory of growth in profitability, characterized by an initial phase of volatility followed by a period of aggressive margin expansion and improved capital efficiency.
- Gross Profitability
- A consistent and linear upward trend is observed in the gross profit margin, which rose from 74.40% in March 2022 to 83.40% by June 2026. This steady increase suggests a sustained improvement in production efficiency or a shift toward higher-margin product mixes.
- Operating and Net Margins
- Operating and net profit margins exhibited a distinct U-shaped pattern. Both metrics declined through 2023, with the operating margin reaching a trough of 18.42% in September 2023 and the net profit margin hitting a low of 15.36% in December 2023. However, a sharp recovery followed, with the operating margin peaking at 43.63% in March 2026 and the net profit margin reaching 34.99% in the same period. This indicates a period of increased expenditure or investment that eventually yielded substantial operating leverage.
- Return on Equity (ROE)
- ROE showed significant fluctuations, starting at 65.69% in March 2022 and dropping to a minimum of 44.46% in September 2023. From that point, a strong recovery occurred, with ROE accelerating to a peak of 81.02% in March 2026. The volatility in ROE closely mirrors the movement of the net profit margin, indicating that bottom-line profitability is the primary driver of shareholder returns.
- Return on Assets (ROA)
- ROA followed a trajectory similar to the other profitability metrics, declining from 13.06% in early 2022 to a low of 8.19% in December 2023. A subsequent steady climb is evident, with ROA reaching a high of 21.68% in March 2026. This improvement suggests a more efficient utilization of the asset base to generate earnings in the latter half of the analyzed period.
Overall, the data indicates a transition from a period of compressed margins and lower returns in 2023 to a state of enhanced profitability and operational efficiency by 2026. The convergence of rising gross margins and expanding operating margins suggests a strong scaling effect in the company's business model.
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Return on Sales
Return on Investment
Gross Profit Margin
Eli Lilly & Co., gross profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Gross margin | 19,706) | 16,222) | 15,920) | 14,593) | 13,110) | 10,504) | 11,129) | 9,268) | 9,133) | 7,095) | 7,565) | 7,639) | 6,505) | 5,333) | 5,754) | 5,363) | 5,058) | 5,738) | ||||||
| Revenue | 22,974) | 19,799) | 19,292) | 17,601) | 15,558) | 12,729) | 13,533) | 11,439) | 11,303) | 8,768) | 9,353) | 9,499) | 8,312) | 6,960) | 7,302) | 6,942) | 6,488) | 7,810) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Gross profit margin1 | 83.40% | 82.83% | 83.04% | 83.03% | 82.64% | 81.70% | 81.31% | 80.91% | 80.75% | 80.16% | 79.25% | 78.67% | 77.77% | 77.67% | 76.77% | 75.61% | 75.98% | 74.40% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Gross Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 71.48% | 70.68% | 70.24% | 69.74% | 70.93% | 70.69% | 69.99% | 67.21% | 62.75% | 62.28% | 62.42% | 65.76% | 68.91% | 69.43% | 70.00% | 69.62% | 70.48% | 69.53% | ||||||
| Amgen Inc. | 67.97% | 66.72% | 65.75% | 64.71% | 62.99% | 61.48% | 59.85% | 58.71% | 61.56% | 64.76% | 68.60% | 72.35% | 72.87% | 73.65% | 74.17% | 73.99% | 74.00% | 73.30% | ||||||
| Bristol-Myers Squibb Co. | 70.16% | 70.46% | 71.08% | 69.50% | 70.29% | 70.47% | 71.08% | 74.91% | 75.38% | 75.71% | 76.24% | 76.54% | 77.01% | 77.68% | 78.04% | 78.82% | 79.13% | 79.62% | ||||||
| Danaher Corp. | 58.51% | 58.94% | 59.11% | 59.53% | 59.66% | 59.74% | 59.50% | 59.37% | 59.27% | 58.39% | 58.74% | 58.77% | 59.17% | 60.22% | 60.21% | 60.65% | 60.77% | 60.77% | ||||||
| Gilead Sciences Inc. | 79.15% | 79.01% | 78.44% | 78.31% | 78.42% | 78.17% | 78.15% | 75.98% | 75.56% | 75.62% | 75.87% | 78.66% | 79.27% | 78.94% | 79.03% | 74.31% | 75.30% | 75.50% | ||||||
| Johnson & Johnson | 67.91% | 67.82% | 67.88% | 68.08% | 67.92% | 68.30% | 69.07% | 69.05% | 69.06% | 69.20% | 68.82% | 68.54% | 68.06% | 67.34% | 67.26% | 67.43% | 67.86% | 67.97% | ||||||
| Merck & Co. Inc. | 72.97% | 73.91% | 74.80% | 77.18% | 76.60% | 76.42% | 76.32% | 75.82% | 75.25% | 74.37% | 73.17% | 72.86% | 72.96% | 72.43% | 70.63% | 70.49% | 70.41% | 70.72% | ||||||
| Pfizer Inc. | 73.18% | 73.51% | 74.33% | 73.39% | 72.12% | 72.28% | 71.94% | 67.73% | 58.18% | 58.09% | 58.10% | 60.97% | 69.61% | 68.61% | 65.77% | 65.53% | 62.18% | 60.35% | ||||||
| Regeneron Pharmaceuticals Inc. | 84.86% | 84.55% | 85.35% | 85.39% | 85.57% | 85.79% | 86.13% | 86.12% | 86.16% | 86.32% | 86.16% | 85.96% | 86.42% | 86.96% | 87.18% | 85.39% | 84.97% | 84.65% | ||||||
| Thermo Fisher Scientific Inc. | 40.80% | 40.78% | 40.93% | 41.27% | 41.18% | 41.34% | 41.28% | 40.77% | 40.76% | 40.40% | 39.90% | 39.87% | 39.75% | 40.28% | 42.24% | 44.42% | 46.63% | 48.37% | ||||||
| Vertex Pharmaceuticals Inc. | 86.00% | 86.24% | 86.24% | 86.28% | 86.11% | 86.03% | 86.11% | 86.12% | 86.45% | 86.86% | 87.21% | 87.80% | 87.92% | 88.04% | 87.90% | 88.00% | 88.13% | 87.95% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Gross profit margin = 100
× (Gross marginQ2 2026
+ Gross marginQ1 2026
+ Gross marginQ4 2025
+ Gross marginQ3 2025)
÷ (RevenueQ2 2026
+ RevenueQ1 2026
+ RevenueQ4 2025
+ RevenueQ3 2025)
= 100 × (19,706 + 16,222 + 15,920 + 14,593)
÷ (22,974 + 19,799 + 19,292 + 17,601)
= 83.40%
2 Click competitor name to see calculations.
An analysis of the quarterly financial results indicates a strong and consistent upward trajectory in both top-line revenue and gross profitability. From March 31, 2022, through June 30, 2026, there is a clear pattern of scaling operations accompanied by improving cost efficiencies.
- Revenue and Gross Margin Growth
- Total revenue grew from 7,810 million US$ in the first quarter of 2022 to 22,974 million US$ by the second quarter of 2026. Parallel to this growth, the absolute gross margin increased from 5,738 million US$ to 19,706 million US$ over the same period, reflecting substantial expansion in the company's earning capacity before operating expenses.
- Gross Profit Margin Expansion
- The gross profit margin percentage demonstrates a steady and monotonic increase. Beginning at 74.40% in March 2022, the margin expanded to 83.40% by June 2026. A significant milestone was reached in March 2024, when the margin first exceeded 80%, subsequently remaining above the 82% threshold for all periods from December 2024 through the end of the analyzed timeframe.
- Profitability Trends and Efficiency
- The correlation between rising revenue and an increasing gross profit margin percentage suggests a high degree of operating leverage. The ability to increase the margin from approximately 74% to over 83% while nearly tripling revenue indicates an improvement in production efficiency or a strategic shift toward higher-margin product offerings.
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Operating Profit Margin
Eli Lilly & Co., operating profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Operating income | 8,978) | 8,915) | 8,374) | 7,366) | 6,867) | 3,695) | 5,149) | 1,526) | 3,715) | 2,509) | 2,388) | 450) | 2,126) | 1,494) | 1,836) | 1,677) | 1,210) | 2,404) | ||||||
| Revenue | 22,974) | 19,799) | 19,292) | 17,601) | 15,558) | 12,729) | 13,533) | 11,439) | 11,303) | 8,768) | 9,353) | 9,499) | 8,312) | 6,960) | 7,302) | 6,942) | 6,488) | 7,810) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Operating profit margin1 | 42.22% | 43.63% | 40.35% | 38.84% | 32.37% | 28.74% | 28.64% | 24.81% | 23.28% | 20.80% | 18.92% | 18.42% | 24.17% | 22.45% | 24.97% | 24.65% | 25.50% | 25.94% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Operating Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 26.20% | 24.41% | 24.65% | 15.16% | 18.80% | 17.56% | 16.22% | 24.89% | 22.31% | 23.50% | 23.49% | 27.32% | 31.03% | 28.49% | 31.21% | 30.59% | 30.33% | 32.68% | ||||||
| Amgen Inc. | 31.51% | 29.77% | 25.83% | 25.14% | 24.45% | 22.71% | 22.66% | 19.97% | 20.96% | 24.72% | 29.35% | 34.55% | 37.50% | 36.07% | 38.57% | 39.31% | 38.04% | 32.78% | ||||||
| Bristol-Myers Squibb Co. | 23.83% | 20.55% | 20.75% | 18.86% | 16.70% | 15.24% | -15.50% | -14.05% | -14.39% | -14.30% | 16.18% | 16.96% | 17.29% | 18.13% | 17.96% | 19.04% | 18.19% | 16.79% | ||||||
| Danaher Corp. | 20.42% | 19.21% | 19.09% | 19.01% | 18.39% | 20.26% | 20.37% | 20.11% | 21.22% | 21.05% | 21.77% | 23.83% | 25.06% | 27.02% | 27.61% | 27.35% | 25.44% | 25.23% | ||||||
| Gilead Sciences Inc. | -8.37% | 35.46% | 34.66% | 36.75% | 28.03% | 28.77% | 5.81% | 2.92% | 9.26% | 5.79% | 28.24% | 30.37% | 31.18% | 33.03% | 27.17% | 22.39% | 25.78% | 26.56% | ||||||
| Johnson & Johnson | 26.47% | 26.39% | 26.85% | 25.44% | 23.67% | 23.59% | 23.42% | 24.42% | 25.31% | 25.04% | 24.90% | 25.55% | 25.61% | 25.21% | 24.63% | 23.89% | 23.47% | 23.76% | ||||||
| Merck & Co. Inc. | 9.58% | 18.18% | 32.64% | 33.73% | 30.00% | 31.51% | 31.03% | 21.60% | 24.75% | 6.93% | 3.92% | 13.08% | 10.34% | 27.85% | 30.27% | 30.66% | 33.04% | 28.85% | ||||||
| Pfizer Inc. | 21.70% | 22.96% | 22.76% | 21.85% | 23.23% | 19.29% | 19.51% | 9.56% | -4.19% | -2.08% | 2.15% | 14.36% | 28.13% | 34.44% | 34.83% | 33.59% | 30.37% | 26.12% | ||||||
| Regeneron Pharmaceuticals Inc. | 24.74% | 24.32% | 24.95% | 25.89% | 27.02% | 27.20% | 28.10% | 28.69% | 28.95% | 29.40% | 30.85% | 32.23% | 34.20% | 35.79% | 38.93% | 45.45% | 48.19% | 55.08% | ||||||
| Thermo Fisher Scientific Inc. | 17.58% | 17.46% | 17.38% | 17.16% | 17.13% | 17.23% | 17.11% | 16.93% | 17.01% | 16.38% | 16.00% | 15.81% | 15.42% | 16.29% | 18.69% | 20.54% | 22.51% | 23.83% | ||||||
| Vertex Pharmaceuticals Inc. | 37.95% | 38.31% | 34.77% | 34.06% | 34.36% | -6.69% | -2.11% | -2.54% | -3.37% | 41.16% | 38.83% | 40.16% | 41.72% | 43.93% | 48.23% | 47.72% | 48.85% | 36.93% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Operating profit margin = 100
× (Operating incomeQ2 2026
+ Operating incomeQ1 2026
+ Operating incomeQ4 2025
+ Operating incomeQ3 2025)
÷ (RevenueQ2 2026
+ RevenueQ1 2026
+ RevenueQ4 2025
+ RevenueQ3 2025)
= 100 × (8,978 + 8,915 + 8,374 + 7,366)
÷ (22,974 + 19,799 + 19,292 + 17,601)
= 42.22%
2 Click competitor name to see calculations.
The operating profit margin exhibits a cyclical trajectory characterized by an initial period of moderate stability, a significant mid-term contraction, and a subsequent phase of aggressive expansion. Over the analyzed period, the margin shifted from a baseline of approximately 25% to a peak exceeding 43%, reflecting a substantial increase in operational efficiency and profitability.
- Stability and Volatility Period (2022-2023)
- During 2022, margins remained relatively stable, fluctuating within a narrow range between 24.65% and 25.94%. However, 2023 introduced significant volatility, with a notable decline that reached a trough of 18.42% in the third quarter. This period indicates a phase where operating expenses grew at a faster rate than revenue, leading to temporary margin compression.
- Recovery and Transition (2024)
- A consistent recovery trend is observed throughout 2024. The operating profit margin climbed steadily from 20.80% in the first quarter to 28.64% by the fourth quarter. This upward movement suggests a successful realignment of cost structures and the beginning of a scaling effect as revenue began to increase more rapidly.
- Aggressive Margin Expansion (2025-2026)
- The period from early 2025 to mid-2026 is marked by a rapid ascent in profitability. Margins accelerated from 28.74% in March 2025 to a peak of 43.63% in March 2026, before a slight moderation to 42.22% in June 2026. This expansion is strongly correlated with massive revenue growth, which increased from approximately 12.7 billion US$ in late 2024 to nearly 23 billion US$ by mid-2026, demonstrating powerful operating leverage where operating income growth significantly outpaced revenue growth.
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Net Profit Margin
Eli Lilly & Co., net profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) | 7,095) | 7,396) | 6,638) | 5,583) | 5,661) | 2,759) | 4,410) | 970) | 2,967) | 2,243) | 2,190) | (57) | 1,763) | 1,345) | 1,938) | 1,452) | 953) | 1,903) | ||||||
| Revenue | 22,974) | 19,799) | 19,292) | 17,601) | 15,558) | 12,729) | 13,533) | 11,439) | 11,303) | 8,768) | 9,353) | 9,499) | 8,312) | 6,960) | 7,302) | 6,942) | 6,488) | 7,810) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Net profit margin1 | 33.53% | 34.99% | 31.67% | 30.99% | 25.91% | 22.66% | 23.51% | 20.48% | 18.86% | 17.08% | 15.36% | 15.55% | 22.01% | 20.54% | 21.88% | 20.63% | 19.58% | 20.90% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Net Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 9.80% | 5.79% | 6.91% | 4.00% | 6.45% | 7.31% | 7.59% | 9.22% | 9.71% | 11.02% | 8.95% | 11.81% | 15.50% | 13.37% | 20.39% | 23.19% | 22.04% | 22.00% | ||||||
| Amgen Inc. | 24.11% | 21.98% | 21.94% | 20.31% | 19.75% | 18.10% | 12.77% | 13.58% | 10.60% | 13.35% | 24.96% | 29.52% | 31.52% | 31.77% | 26.42% | 27.88% | 26.73% | 23.42% | ||||||
| Bristol-Myers Squibb Co. | 18.87% | 15.01% | 14.64% | 12.57% | 10.58% | 11.38% | -18.53% | -15.30% | -14.06% | -13.50% | 17.83% | 18.44% | 17.62% | 15.95% | 13.71% | 14.29% | 14.04% | 13.31% | ||||||
| Danaher Corp. | 15.95% | 14.89% | 14.71% | 14.43% | 14.21% | 15.81% | 16.33% | 16.39% | 17.83% | 18.54% | 19.94% | 22.89% | 22.80% | 23.32% | 22.91% | 21.65% | 20.61% | 21.32% | ||||||
| Gilead Sciences Inc. | -10.86% | 31.51% | 29.43% | 28.41% | 21.98% | 20.87% | 1.68% | 0.45% | 3.82% | 1.78% | 21.03% | 21.60% | 20.18% | 20.87% | 17.02% | 12.44% | 15.22% | 16.60% | ||||||
| Johnson & Johnson | 21.48% | 21.83% | 28.46% | 27.26% | 25.00% | 24.41% | 15.84% | 16.74% | 43.91% | 44.92% | 41.28% | 39.58% | 14.52% | 13.77% | 18.90% | 19.95% | 19.21% | 20.90% | ||||||
| Merck & Co. Inc. | 4.77% | 13.59% | 28.08% | 29.63% | 25.79% | 27.27% | 26.68% | 19.23% | 21.98% | 3.76% | 0.61% | 7.77% | 5.34% | 22.52% | 24.49% | 25.88% | 29.00% | 26.27% | ||||||
| Pfizer Inc. | 6.80% | 11.83% | 12.42% | 15.65% | 16.84% | 12.62% | 12.62% | 7.04% | -4.62% | -0.55% | 3.56% | 15.13% | 27.38% | 31.19% | 31.27% | 29.81% | 28.94% | 27.01% | ||||||
| Regeneron Pharmaceuticals Inc. | 27.86% | 29.65% | 31.41% | 32.13% | 31.37% | 31.94% | 31.07% | 33.61% | 32.04% | 29.45% | 30.14% | 30.47% | 33.93% | 33.81% | 35.64% | 39.17% | 39.97% | 48.06% | ||||||
| Thermo Fisher Scientific Inc. | 15.04% | 15.15% | 15.05% | 15.02% | 15.23% | 15.18% | 14.77% | 14.48% | 14.69% | 14.20% | 13.99% | 13.68% | 13.14% | 13.75% | 15.47% | 15.92% | 17.37% | 18.49% | ||||||
| Vertex Pharmaceuticals Inc. | 35.00% | 35.51% | 32.94% | 31.35% | 31.86% | -8.91% | -4.86% | -4.52% | -4.74% | 39.46% | 36.68% | 35.94% | 35.40% | 35.40% | 37.20% | 37.62% | 38.26% | 30.84% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Net profit margin = 100
× (Net income (loss)Q2 2026
+ Net income (loss)Q1 2026
+ Net income (loss)Q4 2025
+ Net income (loss)Q3 2025)
÷ (RevenueQ2 2026
+ RevenueQ1 2026
+ RevenueQ4 2025
+ RevenueQ3 2025)
= 100 × (7,095 + 7,396 + 6,638 + 5,583)
÷ (22,974 + 19,799 + 19,292 + 17,601)
= 33.53%
2 Click competitor name to see calculations.
The net profit margin exhibits three distinct phases: a period of relative stability, a temporary contraction, and a subsequent phase of significant expansion. Over the analyzed period, there is a clear trajectory toward increased operational efficiency and profitability as revenue scales.
- Margin Stability and Initial Contraction
- Between March 2022 and June 2023, the net profit margin remained relatively stable, fluctuating within a narrow range between 19.58% and 22.01%. A notable decline occurred in the second half of 2023, where the margin dropped to a period low of 15.36% by December 31, 2023. This contraction represents a departure from the previous baseline, indicating a temporary increase in relative costs or a reduction in net earnings relative to total revenue.
- Recovery and Rapid Expansion
- Starting in March 2024, a sustained upward trend in the net profit margin is observed. The margin recovered to 17.08% in March 2024 and climbed consistently through 2024 and 2025. This growth accelerated sharply in the latter half of 2025, with the margin surpassing 30% by September 2025. This trajectory indicates an aggressive improvement in the conversion of revenue into net profit.
- Peak Performance and Scaling
- Profitability reached its zenith in March 2026, peaking at 34.99%. This peak coincides with a substantial increase in quarterly revenue, which grew from 7,810 million US$ in March 2022 to 22,974 million US$ by June 2026. The simultaneous increase in both revenue and net profit margin suggests strong operating leverage, as revenue growth significantly outpaced the growth of expenses, leading to enhanced profitability per dollar of sales.
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Return on Equity (ROE)
Eli Lilly & Co., ROE calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) | 7,095) | 7,396) | 6,638) | 5,583) | 5,661) | 2,759) | 4,410) | 970) | 2,967) | 2,243) | 2,190) | (57) | 1,763) | 1,345) | 1,938) | 1,452) | 953) | 1,903) | ||||||
| Total Eli Lilly and Company shareholders’ equity | 33,879) | 31,198) | 26,535) | 23,793) | 18,273) | 15,765) | 14,192) | 14,240) | 13,562) | 12,812) | 10,772) | 11,220) | 11,064) | 11,190) | 10,650) | 10,070) | 8,545) | 9,331) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| ROE1 | 78.84% | 81.02% | 77.78% | 77.38% | 75.52% | 70.45% | 74.62% | 58.78% | 54.14% | 47.91% | 48.65% | 44.46% | 58.73% | 50.82% | 58.64% | 59.91% | 66.61% | 65.69% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| ROE, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | — | — | — | — | — | 295.42% | 128.66% | 84.91% | 78.77% | 74.85% | 46.94% | 53.86% | 67.50% | 57.14% | 68.60% | 83.83% | 86.24% | 76.64% | ||||||
| Amgen Inc. | 74.80% | 84.87% | 89.06% | 72.82% | 89.11% | 95.59% | 69.59% | 56.20% | 52.83% | 74.93% | 107.78% | 98.82% | 117.67% | 148.04% | 178.97% | 187.11% | 271.85% | 624.78% | ||||||
| Bristol-Myers Squibb Co. | 41.59% | 36.25% | 38.19% | 32.55% | 28.96% | 31.16% | -54.78% | -42.34% | -38.44% | -37.28% | 27.27% | 28.57% | 24.91% | 22.97% | 20.37% | 20.44% | 20.30% | 19.79% | ||||||
| Danaher Corp. | 7.61% | 6.97% | 6.88% | 6.86% | 6.52% | 7.40% | 7.87% | 7.59% | 8.42% | 8.24% | 8.91% | 11.29% | 12.30% | 13.47% | 14.39% | 14.40% | 13.63% | 13.93% | ||||||
| Gilead Sciences Inc. | -27.39% | 39.19% | 37.48% | 37.65% | 32.08% | 31.13% | 2.48% | 0.69% | 5.77% | 2.77% | 24.81% | 26.33% | 25.92% | 26.59% | 21.62% | 15.82% | 20.44% | 22.66% | ||||||
| Johnson & Johnson | 24.76% | 25.92% | 32.87% | 31.69% | 28.88% | 27.92% | 19.68% | 20.93% | 53.14% | 54.95% | 51.11% | 48.61% | 17.37% | 17.95% | 23.36% | 25.68% | 24.05% | 26.54% | ||||||
| Merck & Co. Inc. | 7.57% | 19.48% | 34.70% | 36.71% | 33.49% | 36.07% | 36.96% | 27.30% | 31.52% | 5.71% | 0.97% | 11.17% | 8.04% | 27.82% | 31.57% | 34.32% | 38.34% | 34.68% | ||||||
| Pfizer Inc. | 5.09% | 8.31% | 8.99% | 10.59% | 12.12% | 8.73% | 9.11% | 4.61% | -2.96% | -0.33% | 2.38% | 10.81% | 21.68% | 28.77% | 32.79% | 32.14% | 33.61% | 30.29% | ||||||
| Regeneron Pharmaceuticals Inc. | 13.65% | 14.08% | 14.41% | 14.79% | 14.89% | 15.31% | 15.03% | 15.87% | 15.32% | 14.29% | 15.22% | 16.03% | 17.90% | 17.80% | 19.14% | 25.05% | 27.49% | 39.84% | ||||||
| Thermo Fisher Scientific Inc. | 13.23% | 13.19% | 12.55% | 12.88% | 13.03% | 13.19% | 12.78% | 12.52% | 13.12% | 13.26% | 12.83% | 13.11% | 13.08% | 14.26% | 15.80% | 16.15% | 17.59% | 18.56% | ||||||
| Vertex Pharmaceuticals Inc. | 21.76% | 22.41% | 21.18% | 21.22% | 21.18% | -5.99% | -3.26% | -3.07% | -3.32% | 21.67% | 20.59% | 21.01% | 21.75% | 22.59% | 23.88% | 25.12% | 26.77% | 22.47% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
ROE = 100
× (Net income (loss)Q2 2026
+ Net income (loss)Q1 2026
+ Net income (loss)Q4 2025
+ Net income (loss)Q3 2025)
÷ Total Eli Lilly and Company shareholders’ equity
= 100 × (7,095 + 7,396 + 6,638 + 5,583)
÷ 33,879 = 78.84%
2 Click competitor name to see calculations.
The financial trajectory from March 2022 through June 2026 is characterized by significant growth in both net income and total shareholders' equity, resulting in a robust long-term expansion of return on equity (ROE). While the period was marked by notable volatility in 2023, the subsequent recovery indicates a strong acceleration in profitability relative to the capital base.
- Net Income Trends
- Net income exhibited a general upward trajectory, increasing from 1.9 billion USD in early 2022 to peaks exceeding 7 billion USD by early 2026. A significant anomaly occurred on September 30, 2023, with a net loss of 57 million USD, which created a temporary disruption in earnings. Following this period, income levels accelerated sharply, particularly from late 2024 onwards, suggesting a substantial increase in operational profitability.
- Equity Base Expansion
- Total shareholders' equity demonstrated consistent and substantial growth, rising from 9.3 billion USD in March 2022 to 33.9 billion USD by June 2026. This steady accumulation of equity indicates a strong retention of earnings and an expanding capital foundation to support organizational growth.
- Return on Equity (ROE) Analysis
- ROE followed a U-shaped pattern over the analyzed timeframe. An initial gradual decline was observed from 65.69% in March 2022 to a cyclical low of 44.46% in September 2023, coinciding with the reported net loss. Subsequently, a strong recovery phase began, with ROE climbing steadily to a peak of 81.02% in March 2026. This indicates that in the latter half of the period, net income growth significantly outpaced the growth of the equity base, enhancing the efficiency of shareholder capital utilization.
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Return on Assets (ROA)
Eli Lilly & Co., ROA calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) | 7,095) | 7,396) | 6,638) | 5,583) | 5,661) | 2,759) | 4,410) | 970) | 2,967) | 2,243) | 2,190) | (57) | 1,763) | 1,345) | 1,938) | 1,452) | 953) | 1,903) | ||||||
| Total assets | 142,283) | 116,576) | 112,476) | 114,935) | 100,923) | 89,389) | 78,715) | 75,607) | 71,875) | 63,944) | 64,006) | 57,916) | 54,814) | 53,163) | 49,490) | 47,462) | 47,064) | 46,919) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| ROA1 | 18.77% | 21.68% | 18.35% | 16.02% | 13.67% | 12.42% | 13.45% | 11.07% | 10.22% | 9.60% | 8.19% | 8.61% | 11.85% | 10.70% | 12.62% | 12.71% | 12.09% | 13.06% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| ROA, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 4.67% | 2.66% | 3.15% | 1.78% | 2.74% | 3.08% | 3.17% | 3.57% | 3.76% | 4.03% | 3.61% | 4.78% | 6.42% | 5.64% | 8.53% | 9.49% | 8.83% | 8.71% | ||||||
| Amgen Inc. | 9.14% | 8.43% | 8.51% | 7.77% | 7.53% | 6.64% | 4.45% | 4.65% | 3.44% | 4.05% | 6.91% | 8.36% | 8.84% | 8.92% | 10.06% | 10.73% | 11.09% | 9.67% | ||||||
| Bristol-Myers Squibb Co. | 10.59% | 8.41% | 7.83% | 6.23% | 5.33% | 5.86% | -9.66% | -7.75% | -6.91% | -6.21% | 8.43% | 9.08% | 8.52% | 7.75% | 6.53% | 6.80% | 6.59% | 6.07% | ||||||
| Danaher Corp. | 4.33% | 4.42% | 4.33% | 4.38% | 4.18% | 4.76% | 5.03% | 4.83% | 5.35% | 5.28% | 5.64% | 6.74% | 7.49% | 8.15% | 8.55% | 8.35% | 7.76% | 7.74% | ||||||
| Gilead Sciences Inc. | -6.56% | 16.38% | 14.42% | 13.86% | 11.33% | 10.57% | 0.81% | 0.23% | 1.97% | 0.86% | 9.12% | 9.42% | 8.80% | 9.02% | 7.27% | 5.33% | 6.58% | 7.16% | ||||||
| Johnson & Johnson | 10.46% | 10.47% | 13.46% | 13.03% | 11.72% | 11.26% | 7.81% | 8.24% | 20.99% | 22.37% | 20.98% | 20.85% | 6.81% | 6.49% | 9.57% | 10.94% | 10.33% | 11.12% | ||||||
| Merck & Co. Inc. | 2.44% | 6.94% | 13.34% | 14.69% | 13.96% | 15.14% | 14.62% | 10.34% | 12.20% | 2.18% | 0.34% | 4.32% | 2.98% | 12.09% | 13.30% | 14.25% | 15.48% | 13.29% | ||||||
| Pfizer Inc. | 2.15% | 3.61% | 3.73% | 4.71% | 5.22% | 3.79% | 3.76% | 1.94% | -1.20% | -0.14% | 0.94% | 4.87% | 9.75% | 14.85% | 15.91% | 15.32% | 15.01% | 13.58% | ||||||
| Regeneron Pharmaceuticals Inc. | 10.37% | 10.82% | 11.11% | 11.40% | 11.67% | 11.98% | 11.69% | 12.43% | 11.98% | 11.22% | 11.95% | 12.41% | 14.02% | 13.91% | 14.85% | 19.40% | 20.90% | 30.11% | ||||||
| Thermo Fisher Scientific Inc. | 6.16% | 6.05% | 6.08% | 6.38% | 6.50% | 6.58% | 6.51% | 6.11% | 6.32% | 6.21% | 6.07% | 6.12% | 6.08% | 6.36% | 7.15% | 7.77% | 8.21% | 8.20% | ||||||
| Vertex Pharmaceuticals Inc. | 16.06% | 16.38% | 15.42% | 14.78% | 15.13% | -4.32% | -2.38% | -2.16% | -2.43% | 16.81% | 15.92% | 15.97% | 16.54% | 17.18% | 18.30% | 19.59% | 20.50% | 17.19% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
ROA = 100
× (Net income (loss)Q2 2026
+ Net income (loss)Q1 2026
+ Net income (loss)Q4 2025
+ Net income (loss)Q3 2025)
÷ Total assets
= 100 × (7,095 + 7,396 + 6,638 + 5,583)
÷ 142,283 = 18.77%
2 Click competitor name to see calculations.
The analysis of profitability metrics reveals a period of initial stability, a mid-term contraction, and a subsequent phase of significant expansion in asset efficiency. Return on assets (ROA) exhibited a fluctuating trajectory, transitioning from a stable range in 2022 to a cyclical low in late 2023, before ascending to peak levels in early 2026.
- Asset Base Expansion
- A consistent and accelerating growth trend in total assets is observed, rising from 46,919 million US dollars in March 2022 to 142,283 million US dollars by June 2026. The growth trajectory shifted from incremental increases in 2022 to more aggressive expansion starting in 2024, with the asset base surpassing the 100 billion US dollar threshold in June 2025.
- Net Income Volatility and Recovery
- Net income demonstrated significant variance, particularly during 2023, which included a quarterly loss of 57 million US dollars in September. Following this contraction, a strong recovery phase began in 2024, with profits escalating from 2,243 million US dollars in March 2024 to a high of 7,396 million US dollars by March 2026. This indicates a substantial increase in absolute profitability that outpaced the growth of the asset base in the latter half of the period.
- Return on Assets (ROA) Performance
- The ROA initially fluctuated between 12.09% and 13.06% throughout 2022. A downward trend emerged in 2023, reaching a minimum of 8.19% in December 2023, coinciding with the period of net income instability. A reversal occurred in 2024, with the ratio steadily climbing back above 13%. The most significant efficiency gains were recorded between December 2024 and March 2026, where ROA peaked at 21.68%, signaling an optimized ability to generate profit from the expanded asset base. A slight moderation to 18.77% was observed in the final quarter of the analysis.
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