Analysis of Profitability Ratios
Quarterly Data
Profitability ratios measure the company ability to generate profitable sales from its resources (assets).
Profitability Ratios (Summary)
Pfizer Inc., profitability ratios (quarterly data)
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
The financial metrics over the analyzed periods reveal several noteworthy trends related to profitability and efficiency.
- Gross Profit Margin
- The gross profit margin exhibits a fluctuating pattern initially declining from approximately 76.5% in early 2021 to around 58% by late 2023 and early 2024. From that point, it demonstrates a recovery trend, increasing steadily to surpass 73% by late 2025. This indicates variability in cost control or sales pricing strategies but an overall strengthening in gross profitability in the most recent periods.
- Operating Profit Margin
- The operating profit margin shows an initial upward trend from about 21.2% to a peak near 34.8% by the end of 2022. However, this is followed by a pronounced decline, even turning negative in early to mid-2024, with margins dropping below zero. Subsequently, there is a gradual recovery back into positive territory, reaching over 21% by late 2025. This volatility suggests fluctuations in operating expenses or revenue recognition impacting earnings before interest and taxes.
- Net Profit Margin
- Net profit margin follows a similar trajectory to operating profit margin, beginning around 24% and rising to over 31% by late 2022. A sharp decrease occurs thereafter, with margins declining to negative territory in early 2024. After the trough, a partial rebound occurs, with margins improving and stabilizing around 15-17% toward the end of the observed periods. The net profit trend indicates that, despite temporary adverse impacts possibly due to extraordinary expenses or market conditions, core profitability maintains resilience over time.
- Return on Equity (ROE)
- ROE increases significantly in the initial phases, reaching almost 33% by mid-2022, indicating effective use of shareholders’ equity. This is followed by a substantial decrease into negative and near-zero values in early 2024, reflecting challenges in generating profit relative to equity. A recovery trend is evident afterwards, with ROE rising moderately to over 12% by late 2025, suggesting restored profitability and improved equity utilization.
- Return on Assets (ROA)
- ROA mirrors the patterns found in ROE, with initial growth from 7% to over 15% by late 2022, demonstrating increasing efficiency in asset utilization. Following this, there is a marked decline to slightly negative values in early 2024. A gradual improvement resumes thereafter, with ROA climbing back near 5% by the end of the observed timeframe. This indicates that asset-based profitability faced temporary challenges but managed to recover partially in the later periods.
In summary, the company experienced strong profitability and efficiency improvements through 2022, followed by a challenging period in 2023 and early 2024 marked by contractions in profit margins and returns. From mid-2024 onward, financial performance shows signs of recovery across all key metrics, suggesting successful adjustment to earlier difficulties and strengthening operational and financial health heading towards 2025.
Return on Sales
Return on Investment
Gross Profit Margin
Pfizer Inc., gross profit margin calculation (quarterly data)
| Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 31, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | Dec 31, 2021 | Oct 3, 2021 | Jul 4, 2021 | Apr 4, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Gross profit | 12,482) | 10,875) | 10,870) | 11,854) | 12,439) | 9,983) | 11,500) | 7,006) | 4,223) | 9,770) | 13,600) | 14,640) | 16,575) | 19,094) | 15,677) | 14,102) | 14,103) | 11,903) | 10,359) | ||||||
| Revenues | 16,654) | 14,653) | 13,715) | 17,763) | 17,702) | 13,283) | 14,879) | 14,568) | 13,492) | 13,007) | 18,486) | 24,289) | 22,638) | 27,742) | 25,661) | 23,838) | 24,035) | 18,899) | 14,516) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Gross profit margin1 | 73.39% | 72.12% | 72.28% | 71.94% | 67.73% | 58.18% | 58.09% | 58.10% | 60.97% | 69.61% | 68.61% | 65.77% | 65.53% | 62.18% | 60.35% | 62.08% | 65.28% | 70.96% | 76.46% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Gross Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 69.74% | 70.93% | 70.69% | 69.99% | 67.21% | 62.75% | 62.28% | 62.42% | 65.76% | 68.91% | 69.43% | 70.00% | 69.62% | 70.48% | 69.53% | 68.96% | 67.72% | 65.62% | 64.82% | ||||||
| Amgen Inc. | 64.71% | 62.99% | 61.48% | 59.85% | 58.71% | 61.56% | 64.76% | 68.60% | 72.35% | 72.87% | 73.65% | 74.17% | 73.99% | 74.00% | 73.30% | 73.44% | 74.00% | 73.97% | 74.37% | ||||||
| Bristol-Myers Squibb Co. | 69.50% | 70.29% | 70.47% | 71.08% | 74.91% | 75.38% | 75.71% | 76.24% | 76.54% | 77.01% | 77.68% | 78.04% | 78.82% | 79.13% | 79.62% | 78.57% | 76.92% | 75.88% | 74.42% | ||||||
| Danaher Corp. | 59.53% | 59.66% | 59.74% | 59.50% | 59.37% | 59.27% | 58.39% | 58.74% | 58.77% | 59.17% | 60.22% | 60.21% | 60.65% | 60.77% | 60.77% | 60.95% | 60.44% | 59.24% | 57.60% | ||||||
| Eli Lilly & Co. | 83.03% | 82.64% | 81.70% | 81.31% | 80.91% | 80.75% | 80.16% | 79.25% | 78.67% | 77.77% | 77.67% | 76.77% | 75.61% | 75.98% | 74.40% | 74.18% | 74.85% | 74.27% | 75.88% | ||||||
| Gilead Sciences Inc. | 78.31% | 78.42% | 78.17% | 78.15% | 75.98% | 75.56% | 75.62% | 75.87% | 78.66% | 79.27% | 78.94% | 79.03% | 74.31% | 75.30% | 75.50% | 75.56% | 80.23% | 79.90% | 80.32% | ||||||
| Johnson & Johnson | 68.08% | 67.92% | 68.30% | 69.07% | 69.05% | 69.06% | 69.20% | 68.82% | 68.54% | 68.06% | 67.34% | 67.26% | 67.43% | 67.86% | 67.97% | 68.16% | 67.51% | 67.00% | 66.24% | ||||||
| Merck & Co. Inc. | 77.18% | 76.60% | 76.42% | 76.32% | 75.82% | 75.25% | 74.37% | 73.17% | 72.86% | 72.96% | 72.43% | 70.63% | 70.49% | 70.41% | 70.72% | 72.02% | 67.95% | 67.48% | 66.99% | ||||||
| Regeneron Pharmaceuticals Inc. | 85.39% | 85.57% | 85.79% | 86.13% | 86.12% | 86.16% | 86.32% | 86.16% | 85.96% | 86.42% | 86.96% | 87.18% | 85.39% | 84.97% | 84.65% | 84.83% | 86.65% | 86.85% | 86.84% | ||||||
| Thermo Fisher Scientific Inc. | 41.27% | 41.18% | 41.34% | 41.28% | 40.77% | 40.76% | 40.40% | 39.90% | 39.87% | 39.75% | 40.28% | 42.24% | 44.42% | 46.63% | 48.37% | 50.08% | 51.05% | 51.29% | 51.47% | ||||||
| Vertex Pharmaceuticals Inc. | 86.28% | 86.11% | 86.03% | 86.11% | 86.12% | 86.45% | 86.86% | 87.21% | 87.80% | 87.92% | 88.04% | 87.90% | 88.00% | 88.13% | 87.95% | 88.06% | 87.94% | 87.89% | 88.06% | ||||||
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
1 Q3 2025 Calculation
Gross profit margin = 100
× (Gross profitQ3 2025
+ Gross profitQ2 2025
+ Gross profitQ1 2025
+ Gross profitQ4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (12,482 + 10,875 + 10,870 + 11,854)
÷ (16,654 + 14,653 + 13,715 + 17,763)
= 73.39%
2 Click competitor name to see calculations.
The financial data reveals fluctuating patterns in gross profit, revenues, and gross profit margin over the analyzed periods. The following highlights the observed trends and insights:
- Revenues
- Revenues displayed significant variability, with peaks occurring in the mid-2021 and early 2022 periods (notably reaching above $27 billion in July 2022) followed by sharp declines in the subsequent quarters. The latter half of 2023 showed a resurgence in revenues, gradually increasing from approximately $13 billion to over $17 billion by late 2024. However, revenues again dipped in early 2025 before recovering slightly towards the third quarter of that year.
- Gross Profit
- Gross profit followed a somewhat similar trend to revenues but with less pronounced relative volatility. The highest gross profit was observed in July 2022 at roughly $19 billion, consistent with peak revenue periods. Thereafter, gross profit showed a decline by the end of 2023 down to around $4.2 billion in October 2023, before gradually recovering and stabilizing near $12.5 billion by the third quarter of 2025. Notably, there was a significant drop in gross profit toward late 2023 not fully aligned with revenue movements, suggesting possible cost or margin pressures in that timeframe.
- Gross Profit Margin
- The gross profit margin demonstrated a declining trend from over 76% in early 2021 to its lowest point around 58% in late 2023 and early 2024, indicating a decrease in profitability relative to revenues during this period. From early 2024 onwards, the margin improved steadily, reaching above 73% by the third quarter of 2025. The restoration of higher margins in recent periods suggests improved cost management or a shift in the sales mix favoring higher-margin products.
In summary, the company experienced a cycle of growth and contraction in revenues and gross profit between 2021 and 2025, with a pronounced dip at the end of 2023 impacting profitability. The improving gross profit margin from 2024 onward may indicate operational efficiencies or product portfolio adjustments contributing to enhanced profitability despite fluctuating revenue levels.
Operating Profit Margin
Pfizer Inc., operating profit margin calculation (quarterly data)
| Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 31, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | Dec 31, 2021 | Oct 3, 2021 | Jul 4, 2021 | Apr 4, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Operating income (loss) | 3,851) | 3,783) | 3,738) | 2,347) | 4,959) | 1,003) | 4,102) | (4,289) | (3,170) | 2,194) | 6,544) | 4,381) | 8,943) | 12,219) | 9,401) | 2,991) | 6,147) | 5,606) | 4,689) | ||||||
| Revenues | 16,654) | 14,653) | 13,715) | 17,763) | 17,702) | 13,283) | 14,879) | 14,568) | 13,492) | 13,007) | 18,486) | 24,289) | 22,638) | 27,742) | 25,661) | 23,838) | 24,035) | 18,899) | 14,516) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Operating profit margin1 | 21.85% | 23.23% | 19.29% | 19.51% | 9.56% | -4.19% | -2.08% | 2.15% | 14.36% | 28.13% | 34.44% | 34.83% | 33.59% | 30.37% | 26.12% | 23.91% | 24.67% | 24.12% | 21.20% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Operating Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 15.16% | 18.80% | 17.56% | 16.22% | 24.89% | 22.31% | 23.50% | 23.49% | 27.32% | 31.03% | 28.49% | 31.21% | 30.59% | 30.33% | 32.68% | 31.89% | 30.09% | 28.95% | 23.63% | ||||||
| Amgen Inc. | 25.14% | 24.45% | 22.71% | 22.66% | 19.97% | 20.96% | 24.72% | 29.35% | 34.55% | 37.50% | 36.07% | 38.57% | 39.31% | 38.04% | 32.78% | 31.44% | 30.14% | 30.72% | 37.23% | ||||||
| Bristol-Myers Squibb Co. | 18.86% | 16.70% | 15.24% | -15.50% | -14.05% | -14.39% | -14.30% | 16.18% | 16.96% | 17.29% | 18.13% | 17.96% | 19.04% | 18.19% | 16.79% | 15.91% | -15.73% | -17.02% | -19.19% | ||||||
| Danaher Corp. | 19.01% | 18.39% | 20.26% | 20.37% | 20.11% | 21.22% | 21.05% | 21.77% | 23.83% | 25.06% | 27.02% | 27.61% | 27.35% | 25.44% | 25.23% | 25.35% | 24.63% | 25.04% | 22.30% | ||||||
| Eli Lilly & Co. | 38.84% | 32.37% | 28.74% | 28.64% | 24.81% | 23.28% | 20.80% | 18.92% | 18.42% | 24.17% | 22.45% | 24.97% | 24.65% | 25.50% | 25.94% | 22.45% | 23.17% | 21.81% | 22.06% | ||||||
| Gilead Sciences Inc. | 36.75% | 28.03% | 28.77% | 5.81% | 2.92% | 9.26% | 5.79% | 28.24% | 30.37% | 31.18% | 33.03% | 27.17% | 22.39% | 25.78% | 26.56% | 36.72% | 42.79% | 37.20% | 18.07% | ||||||
| Johnson & Johnson | 25.44% | 23.67% | 23.59% | 23.42% | 24.42% | 25.31% | 25.04% | 24.90% | 25.55% | 25.61% | 25.21% | 24.63% | 23.89% | 23.47% | 23.76% | 24.95% | 24.69% | 25.23% | 24.10% | ||||||
| Merck & Co. Inc. | 33.73% | 30.00% | 31.51% | 31.03% | 21.60% | 24.75% | 6.93% | 3.92% | 13.08% | 10.34% | 27.85% | 30.27% | 30.66% | 33.04% | 28.85% | 25.74% | 14.07% | 10.64% | 14.02% | ||||||
| Regeneron Pharmaceuticals Inc. | 25.89% | 27.02% | 27.20% | 28.10% | 28.69% | 28.95% | 29.40% | 30.85% | 32.23% | 34.20% | 35.79% | 38.93% | 45.45% | 48.19% | 55.08% | 55.67% | 55.19% | 53.94% | 43.37% | ||||||
| Thermo Fisher Scientific Inc. | 17.16% | 17.13% | 17.23% | 17.11% | 16.93% | 17.01% | 16.38% | 16.00% | 15.81% | 15.42% | 16.29% | 18.69% | 20.54% | 22.51% | 23.83% | 25.57% | 27.04% | 28.00% | 27.68% | ||||||
| Vertex Pharmaceuticals Inc. | 34.06% | 34.36% | -6.69% | -2.11% | -2.54% | -3.37% | 41.16% | 38.83% | 40.16% | 41.72% | 43.93% | 48.23% | 47.72% | 48.85% | 36.93% | 36.73% | 37.17% | 33.93% | 47.14% | ||||||
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
1 Q3 2025 Calculation
Operating profit margin = 100
× (Operating income (loss)Q3 2025
+ Operating income (loss)Q2 2025
+ Operating income (loss)Q1 2025
+ Operating income (loss)Q4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (3,851 + 3,783 + 3,738 + 2,347)
÷ (16,654 + 14,653 + 13,715 + 17,763)
= 21.85%
2 Click competitor name to see calculations.
- Operating Income (Loss)
- Operating income exhibited significant fluctuation across the observed periods. Initially, there was a strong upward trend from April 2021 through July 2022, peaking at over $12 billion. However, a notable decline followed, with operating income turning negative during the last two quarters of 2023, reflecting losses exceeding $4 billion. In 2024, operating income recovered partially, fluctuating between approximately $1 billion and $5 billion, and stabilized around $3.7 to $3.8 billion in the latest quarters of 2025.
- Revenues
- Revenues experienced growth from April 2021 to July 2022, reaching nearly $28 billion. This was followed by a downward trend through 2023, hitting a low point around $13 billion to $14 billion. A moderate recovery began in 2024, with revenues rising above $17 billion at times, although some quarters showed a decline back into the $13 billion to $14 billion range. The latest data from 2025 shows an increasing trend again, with revenues approaching $16.6 billion.
- Operating Profit Margin
- Operating profit margin generally improved from April 2021, rising from around 21% to a peak exceeding 34% by December 2022. Subsequently, the margin declined sharply in 2023, even turning negative in some quarters, indicating operational inefficiencies or extraordinary expenses during that period. The margin began to recover in 2024, moving from negative to positive territory, reaching near 20% later in the year. In 2025, the margin remained stable in the low- to mid-20% range, suggesting normalization of profitability relative to revenues.
- Overall Trends and Insights
- The data reveals a period of strong financial performance in 2021 and early-to-mid 2022, characterized by rising revenues, increasing operating income, and high operating margins. Following this peak, the company faced a challenging phase in 2023 with declining revenues and a transition into operating losses, reflected also by sharply decreased and negative operating margins. Recovery commenced in 2024, accompanied by improved margins and partial restoration of operating income and revenues. The latest available data in 2025 suggests a return to more consistent profitability and moderate revenue growth, although not yet reaching the earlier peak levels.
Net Profit Margin
Pfizer Inc., net profit margin calculation (quarterly data)
| Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 31, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | Dec 31, 2021 | Oct 3, 2021 | Jul 4, 2021 | Apr 4, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | 3,541) | 2,910) | 2,967) | 410) | 4,465) | 41) | 3,115) | (3,369) | (2,382) | 2,327) | 5,543) | 4,994) | 8,608) | 9,906) | 7,864) | 3,393) | 8,146) | 5,563) | 4,877) | ||||||
| Revenues | 16,654) | 14,653) | 13,715) | 17,763) | 17,702) | 13,283) | 14,879) | 14,568) | 13,492) | 13,007) | 18,486) | 24,289) | 22,638) | 27,742) | 25,661) | 23,838) | 24,035) | 18,899) | 14,516) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Net profit margin1 | 15.65% | 16.84% | 12.62% | 12.62% | 7.04% | -4.62% | -0.55% | 3.56% | 15.13% | 27.38% | 31.19% | 31.27% | 29.81% | 28.94% | 27.01% | 27.04% | 28.77% | 23.86% | 24.03% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Net Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 4.00% | 6.45% | 7.31% | 7.59% | 9.22% | 9.71% | 11.02% | 8.95% | 11.81% | 15.50% | 13.37% | 20.39% | 23.19% | 22.04% | 22.00% | 20.54% | 13.66% | 12.40% | 10.28% | ||||||
| Amgen Inc. | 20.31% | 19.75% | 18.10% | 12.77% | 13.58% | 10.60% | 13.35% | 24.96% | 29.52% | 31.52% | 31.77% | 26.42% | 27.88% | 26.73% | 23.42% | 24.25% | 23.03% | 23.80% | 29.60% | ||||||
| Bristol-Myers Squibb Co. | 12.57% | 10.58% | 11.38% | -18.53% | -15.30% | -14.06% | -13.50% | 17.83% | 18.44% | 17.62% | 15.95% | 13.71% | 14.29% | 14.04% | 13.31% | 15.08% | -11.89% | -11.44% | -14.53% | ||||||
| Danaher Corp. | 14.43% | 14.21% | 15.81% | 16.33% | 16.39% | 17.83% | 18.54% | 19.94% | 22.89% | 22.80% | 23.32% | 22.91% | 21.65% | 20.61% | 21.32% | 21.84% | 20.97% | 21.00% | 19.17% | ||||||
| Eli Lilly & Co. | 30.99% | 25.91% | 22.66% | 23.51% | 20.48% | 18.86% | 17.08% | 15.36% | 15.55% | 22.01% | 20.54% | 21.88% | 20.63% | 19.58% | 20.90% | 19.71% | 21.52% | 22.71% | 23.91% | ||||||
| Gilead Sciences Inc. | 28.41% | 21.98% | 20.87% | 1.68% | 0.45% | 3.82% | 1.78% | 21.03% | 21.60% | 20.18% | 20.87% | 17.02% | 12.44% | 15.22% | 16.60% | 23.05% | 27.21% | 19.62% | 1.19% | ||||||
| Johnson & Johnson | 27.26% | 25.00% | 24.41% | 15.84% | 16.74% | 43.91% | 44.92% | 41.28% | 39.58% | 14.52% | 13.77% | 18.90% | 19.95% | 19.21% | 20.90% | 22.26% | 19.55% | 19.92% | 17.95% | ||||||
| Merck & Co. Inc. | 29.63% | 25.79% | 27.27% | 26.68% | 19.23% | 21.98% | 3.76% | 0.61% | 7.77% | 5.34% | 22.52% | 24.49% | 25.88% | 29.00% | 26.27% | 26.79% | 15.09% | 11.83% | 15.09% | ||||||
| Regeneron Pharmaceuticals Inc. | 32.13% | 31.37% | 31.94% | 31.07% | 33.61% | 32.04% | 29.45% | 30.14% | 30.47% | 33.93% | 33.81% | 35.64% | 39.17% | 39.97% | 48.06% | 50.25% | 51.65% | 50.11% | 43.53% | ||||||
| Thermo Fisher Scientific Inc. | 15.02% | 15.23% | 15.18% | 14.77% | 14.48% | 14.69% | 14.20% | 13.99% | 13.68% | 13.14% | 13.75% | 15.47% | 15.92% | 17.37% | 18.49% | 19.70% | 21.93% | 22.47% | 22.08% | ||||||
| Vertex Pharmaceuticals Inc. | 31.35% | 31.86% | -8.91% | -4.86% | -4.52% | -4.74% | 39.46% | 36.68% | 35.94% | 35.40% | 35.40% | 37.20% | 37.62% | 38.26% | 30.84% | 30.92% | 30.52% | 29.80% | 43.06% | ||||||
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
1 Q3 2025 Calculation
Net profit margin = 100
× (Net income (loss) attributable to Pfizer Inc. common shareholdersQ3 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ2 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ1 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ4 2024)
÷ (RevenuesQ3 2025
+ RevenuesQ2 2025
+ RevenuesQ1 2025
+ RevenuesQ4 2024)
= 100 × (3,541 + 2,910 + 2,967 + 410)
÷ (16,654 + 14,653 + 13,715 + 17,763)
= 15.65%
2 Click competitor name to see calculations.
- Net Income Trend
- The net income attributable to common shareholders exhibits significant volatility over the observed periods. There was strong growth from early 2021 through mid-2022, peaking notably in July 2022. Following this peak, a marked decline occurred, including two consecutive quarters of negative net income in late 2023. Recovery signs appear in early 2024, with positive net income resuming and fluctuating at moderate levels through mid-2025.
- Revenue Trend
- Revenues showed steady growth from early 2021 until mid-2022, reaching a high point in July 2022. Subsequently, revenues declined sharply toward early 2023, hitting a low in the middle of that year. Thereafter, a gradual recovery phase ensued, with revenues generally increasing from late 2023 into mid-2025, though levels did not fully return to the mid-2022 peak within the observed timeframe.
- Net Profit Margin Analysis
- The net profit margin closely follows the net income trend, showing healthy, stable margins around 24% to 31% during 2021 and early 2022. Margins diminished significantly in late 2023, including some negative margin quarters, corresponding to net income losses. Starting in early 2024, the margin began improving steadily, reaching around 15% to 17% by mid-2025, indicating recovery in profitability but not yet matching earlier peak profitability levels.
- Overall Insights
- The financial data indicates that there was a peak in both revenue and profitability in mid-2022, followed by a period of financial strain characterized by declining revenues, net losses, and reduced profit margins through late 2023. This was succeeded by a phase of recovery in both top-line revenue and bottom-line profitability from early 2024 onward. However, the company had not fully returned to the prior high-performance levels by mid-2025. The fluctuations highlight a period of uncertainty and restructuring, with improvements apparent but full stabilization yet to be achieved.
Return on Equity (ROE)
Pfizer Inc., ROE calculation (quarterly data)
| Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 31, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | Dec 31, 2021 | Oct 3, 2021 | Jul 4, 2021 | Apr 4, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | 3,541) | 2,910) | 2,967) | 410) | 4,465) | 41) | 3,115) | (3,369) | (2,382) | 2,327) | 5,543) | 4,994) | 8,608) | 9,906) | 7,864) | 3,393) | 8,146) | 5,563) | 4,877) | ||||||
| Total Pfizer Inc. shareholders’ equity | 92,801) | 88,695) | 90,338) | 88,203) | 92,286) | 87,700) | 92,282) | 89,014) | 96,934) | 99,019) | 100,970) | 95,661) | 92,631) | 87,208) | 82,424) | 77,201) | 75,691) | 70,042) | 68,620) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROE1 | 10.59% | 12.12% | 8.73% | 9.11% | 4.61% | -2.96% | -0.33% | 2.38% | 10.81% | 21.68% | 28.77% | 32.79% | 32.14% | 33.61% | 30.29% | 28.47% | 26.28% | 18.86% | 16.23% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROE, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | — | — | 295.42% | 128.66% | 84.91% | 78.77% | 74.85% | 46.94% | 53.86% | 67.50% | 57.14% | 68.60% | 83.83% | 86.24% | 76.64% | 74.91% | 55.60% | 53.01% | 37.63% | ||||||
| Amgen Inc. | 72.82% | 89.11% | 95.59% | 69.59% | 56.20% | 52.83% | 74.93% | 107.78% | 98.82% | 117.67% | 148.04% | 178.97% | 187.11% | 271.85% | 624.78% | 87.96% | 68.26% | 69.67% | 75.91% | ||||||
| Bristol-Myers Squibb Co. | 32.55% | 28.96% | 31.16% | -54.78% | -42.34% | -38.44% | -37.28% | 27.27% | 28.57% | 24.91% | 22.97% | 20.37% | 20.44% | 20.30% | 19.79% | 19.46% | -14.52% | -13.80% | -16.54% | ||||||
| Danaher Corp. | 6.86% | 6.52% | 7.40% | 7.87% | 7.59% | 8.42% | 8.24% | 8.91% | 11.29% | 12.30% | 13.47% | 14.39% | 14.40% | 13.63% | 13.93% | 14.24% | 13.54% | 13.12% | 11.76% | ||||||
| Eli Lilly & Co. | 77.38% | 75.52% | 70.45% | 74.62% | 58.78% | 54.14% | 47.91% | 48.65% | 44.46% | 58.73% | 50.82% | 58.64% | 59.91% | 66.61% | 65.69% | 62.16% | 76.99% | 94.20% | 88.31% | ||||||
| Gilead Sciences Inc. | 37.65% | 32.08% | 31.13% | 2.48% | 0.69% | 5.77% | 2.77% | 24.81% | 26.33% | 25.92% | 26.59% | 21.62% | 15.82% | 20.44% | 22.66% | 29.55% | 34.44% | 26.20% | 1.59% | ||||||
| Johnson & Johnson | 31.69% | 28.88% | 27.92% | 19.68% | 20.93% | 53.14% | 54.95% | 51.11% | 48.61% | 17.37% | 17.95% | 23.36% | 25.68% | 24.05% | 26.54% | 28.20% | 25.44% | 25.53% | 22.96% | ||||||
| Merck & Co. Inc. | 36.71% | 33.49% | 36.07% | 36.96% | 27.30% | 31.52% | 5.71% | 0.97% | 11.17% | 8.04% | 27.82% | 31.57% | 34.32% | 38.34% | 34.68% | 34.17% | 20.10% | 16.73% | 26.08% | ||||||
| Regeneron Pharmaceuticals Inc. | 14.79% | 14.89% | 15.31% | 15.03% | 15.87% | 15.32% | 14.29% | 15.22% | 16.03% | 17.90% | 17.80% | 19.14% | 25.05% | 27.49% | 39.84% | 43.03% | 40.53% | 41.02% | 33.43% | ||||||
| Thermo Fisher Scientific Inc. | 12.88% | 13.03% | 13.19% | 12.78% | 12.52% | 13.12% | 13.26% | 12.83% | 13.11% | 13.08% | 14.26% | 15.80% | 16.15% | 17.59% | 18.56% | 18.94% | 22.13% | 23.32% | 22.60% | ||||||
| Vertex Pharmaceuticals Inc. | 21.22% | 21.18% | -5.99% | -3.26% | -3.07% | -3.32% | 21.67% | 20.59% | 21.01% | 21.75% | 22.59% | 23.88% | 25.12% | 26.77% | 22.47% | 23.19% | 22.83% | 21.66% | 30.76% | ||||||
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
1 Q3 2025 Calculation
ROE = 100
× (Net income (loss) attributable to Pfizer Inc. common shareholdersQ3 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ2 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ1 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ4 2024)
÷ Total Pfizer Inc. shareholders’ equity
= 100 × (3,541 + 2,910 + 2,967 + 410)
÷ 92,801 = 10.59%
2 Click competitor name to see calculations.
The analysis of the financial performance over the examined periods reveals notable fluctuations in net income, shareholders' equity, and return on equity (ROE) for the company. The net income attributable to common shareholders has exhibited considerable volatility, including periods of strong profitability interspersed with quarters showing negative or significantly reduced earnings.
- Net Income Trends
- The net income figures demonstrate a pattern of initial growth reaching a peak in the quarters of 2021, followed by a sharp decline in late 2021 and early 2023, where losses were recorded. After hitting negative values in the third and fourth quarters of 2023, the net income returned to positive figures, albeit with fluctuations in magnitude. The most recent data indicates a recovery trend with positive net income continuing into 2024 and 2025.
- Shareholders’ Equity Development
- Shareholders’ equity shows a steady upward trend throughout the period, increasing from approximately $68.6 billion in early 2021 to about $92.8 billion in mid-2025. Despite some minor fluctuations, the overall growth in equity suggests continued accumulation of retained earnings and possibly other equity augmenting activities, which indicate a strengthening equity base.
- Return on Equity (ROE) Analysis
- The ROE metric starts at a moderate level in early 2021, increasing significantly and peaking in late 2021 and early 2022, reaching values above 30%. Subsequently, ROE declines sharply during 2023, correlating with the observed losses in net income. The lowest point is recorded near the end of 2023 and the beginning of 2024, where ROE turns negative, signaling deteriorated profitability relative to equity. However, the ratio shows signs of gradual recovery in the following quarters, moving back into positive territory and stabilizing around the mid-teens percentage by mid-2025.
- Overall Insights
- The interplay between net income volatility and the steady increase in shareholders’ equity suggests that while the company faced some profitability challenges, it maintained a solid capital base. The temporary negative ROE indicates periods of operational or market difficulties but the subsequent recovery implies effective management responses or market conditions improving. Investors and stakeholders should note the cyclicality in earnings and the resilience reflected in equity growth, with a cautious but optimistic outlook given the recent trend in profitability and returns.
Return on Assets (ROA)
Pfizer Inc., ROA calculation (quarterly data)
| Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 31, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | Dec 31, 2021 | Oct 3, 2021 | Jul 4, 2021 | Apr 4, 2021 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net income (loss) attributable to Pfizer Inc. common shareholders | 3,541) | 2,910) | 2,967) | 410) | 4,465) | 41) | 3,115) | (3,369) | (2,382) | 2,327) | 5,543) | 4,994) | 8,608) | 9,906) | 7,864) | 3,393) | 8,146) | 5,563) | 4,877) | ||||||
| Total assets | 208,731) | 206,095) | 208,028) | 213,396) | 219,476) | 216,193) | 221,095) | 226,501) | 215,021) | 220,168) | 195,617) | 197,205) | 194,350) | 195,290) | 183,841) | 181,476) | 179,188) | 169,920) | 158,818) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROA1 | 4.71% | 5.22% | 3.79% | 3.76% | 1.94% | -1.20% | -0.14% | 0.94% | 4.87% | 9.75% | 14.85% | 15.91% | 15.32% | 15.01% | 13.58% | 12.11% | 11.10% | 7.78% | 7.01% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROA, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 1.78% | 2.74% | 3.08% | 3.17% | 3.57% | 3.76% | 4.03% | 3.61% | 4.78% | 6.42% | 5.64% | 8.53% | 9.49% | 8.83% | 8.71% | 7.88% | 5.06% | 4.50% | 3.43% | ||||||
| Amgen Inc. | 7.77% | 7.53% | 6.64% | 4.45% | 4.65% | 3.44% | 4.05% | 6.91% | 8.36% | 8.84% | 8.92% | 10.06% | 10.73% | 11.09% | 9.67% | 9.63% | 8.63% | 9.61% | 11.33% | ||||||
| Bristol-Myers Squibb Co. | 6.23% | 5.33% | 5.86% | -9.66% | -7.75% | -6.91% | -6.21% | 8.43% | 9.08% | 8.52% | 7.75% | 6.53% | 6.80% | 6.59% | 6.07% | 6.40% | -4.87% | -4.58% | -5.53% | ||||||
| Danaher Corp. | 4.38% | 4.18% | 4.76% | 5.03% | 4.83% | 5.35% | 5.28% | 5.64% | 6.74% | 7.49% | 8.15% | 8.55% | 8.35% | 7.76% | 7.74% | 7.73% | 7.13% | 7.19% | 6.30% | ||||||
| Eli Lilly & Co. | 16.02% | 13.67% | 12.42% | 13.45% | 11.07% | 10.22% | 9.60% | 8.19% | 8.61% | 11.85% | 10.70% | 12.62% | 12.71% | 12.09% | 13.06% | 11.44% | 12.39% | 12.70% | 13.01% | ||||||
| Gilead Sciences Inc. | 13.86% | 11.33% | 10.57% | 0.81% | 0.23% | 1.97% | 0.86% | 9.12% | 9.42% | 8.80% | 9.02% | 7.27% | 5.33% | 6.58% | 7.16% | 9.16% | 11.02% | 7.59% | 0.45% | ||||||
| Johnson & Johnson | 13.03% | 11.72% | 11.26% | 7.81% | 8.24% | 20.99% | 22.37% | 20.98% | 20.85% | 6.81% | 6.49% | 9.57% | 10.94% | 10.33% | 11.12% | 11.47% | 9.98% | 10.07% | 8.76% | ||||||
| Merck & Co. Inc. | 14.69% | 13.96% | 15.14% | 14.62% | 10.34% | 12.20% | 2.18% | 0.34% | 4.32% | 2.98% | 12.09% | 13.30% | 14.25% | 15.48% | 13.29% | 12.35% | 7.70% | 6.14% | 7.73% | ||||||
| Regeneron Pharmaceuticals Inc. | 11.40% | 11.67% | 11.98% | 11.69% | 12.43% | 11.98% | 11.22% | 11.95% | 12.41% | 14.02% | 13.91% | 14.85% | 19.40% | 20.90% | 30.11% | 31.75% | 29.55% | 28.88% | 22.53% | ||||||
| Thermo Fisher Scientific Inc. | 6.38% | 6.50% | 6.58% | 6.51% | 6.11% | 6.32% | 6.21% | 6.07% | 6.12% | 6.08% | 6.36% | 7.15% | 7.77% | 8.21% | 8.20% | 8.12% | 11.64% | 12.70% | 12.02% | ||||||
| Vertex Pharmaceuticals Inc. | 14.78% | 15.13% | -4.32% | -2.38% | -2.16% | -2.43% | 16.81% | 15.92% | 15.97% | 16.54% | 17.18% | 18.30% | 19.59% | 20.50% | 17.19% | 17.44% | 17.25% | 16.30% | 22.80% | ||||||
Based on: 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03), 10-K (reporting date: 2021-12-31), 10-Q (reporting date: 2021-10-03), 10-Q (reporting date: 2021-07-04), 10-Q (reporting date: 2021-04-04).
1 Q3 2025 Calculation
ROA = 100
× (Net income (loss) attributable to Pfizer Inc. common shareholdersQ3 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ2 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ1 2025
+ Net income (loss) attributable to Pfizer Inc. common shareholdersQ4 2024)
÷ Total assets
= 100 × (3,541 + 2,910 + 2,967 + 410)
÷ 208,731 = 4.71%
2 Click competitor name to see calculations.
The financial performance over the analyzed periods reflects notable fluctuations in net income and variations in asset utilization efficiency as indicated by the return on assets (ROA).
- Net Income Trends
- The net income attributable to common shareholders showed a generally positive trend from early 2021 through the end of 2022, peaking in the third quarter of 2021 and maintaining relatively high values throughout 2022, with some volatility in the fourth quarter of 2022. However, beginning in 2023, a significant downturn is evident, with negative net income recorded in the third and fourth quarters of 2023. Recovery then appears in the early quarters of 2024, followed by fluctuations with intermittent periods of moderate profitability through mid-2025.
- Total Assets Dynamics
- Total assets increased steadily from early 2021 until the end of 2023, peaking near the close of that year. Subsequently, a gradual decline in total assets is noted through mid-2025. This suggests an initial phase of asset growth potentially linked to investment or acquisition activities, followed by a period of stabilization and mild contraction.
- Return on Assets (ROA)
- The ROA demonstrates a strong improvement from early 2021 into 2022, with values rising from approximately 7% to over 15%, indicating increased efficiency in generating net income from the company's asset base. This upward trend culminates towards the end of 2022, after which there is a sharp decline throughout 2023, corresponding with the negative and low net income figures during that time. ROA briefly passes into negative territory in early 2024, reflecting unprofitable quarters. A gradual recovery occurs over the subsequent quarters, though ROA remains below the peak levels observed in 2022, stabilizing around mid-single digits by mid-2025.
In summary, the data reveals a cycle beginning with strong profitability and asset growth, followed by a period of financial stress with operating losses and diminishing asset efficiency. While there is evidence of recovery in profitability and ROA starting from early 2024, performance levels do not return to the prior peaks within the observed timeframe. The fluctuations suggest the presence of external or internal challenges influencing earnings, along with strategic adjustments affecting asset base size and utilization.