Profitability ratios measure the company ability to generate profitable sales from its resources (assets).
Profitability Ratios (Summary)
Return on Sales
Return on Investment
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
An analysis of the profitability ratios reveals a significant divergence between operational stability and bottom-line volatility. While core production and operating efficiencies remained relatively consistent throughout the observed period, the net profitability and return metrics experienced extreme fluctuations, suggesting the influence of non-operational factors or one-time financial events.
- Gross Profit Margin
- The gross profit margin demonstrated a high degree of stability, maintaining a tight range between 67.26% and 69.20%. A gradual increase was observed from late 2022, peaking at 69.20% in March 2024, followed by a slow normalization toward 67.56% by September 2026. This indicates a consistent ability to manage direct costs relative to revenue.
- Operating Profit Margin
- Operational efficiency remained steady, with margins generally fluctuating between 23% and 26%. A period of relative strength occurred between April 2023 and June 2024, peaking at 25.31%. A subsequent dip to 23.42% in December 2024 was followed by a recovery to a period high of 26.85% in December 2025, before settling at 24.90% at the end of the period.
- Net Profit Margin
- This metric exhibited extreme volatility. After starting near 20%, it dropped to 13.77% in April 2023 before an anomalous surge beginning in October 2023. The margin peaked at 44.92% in March 2024, more than doubling previous levels. This was followed by a sharp correction to 15.84% by December 2024, a secondary recovery peaking at 28.46% in December 2025, and a final decline to 16.20% in September 2026.
- Return on Equity (ROE) and Return on Assets (ROA)
- Both ROE and ROA tracked the volatility of the net profit margin closely. ROE experienced a massive spike from 17.37% in July 2023 to a peak of 54.95% in March 2024, before declining to 19.74% by September 2026. Similarly, ROA rose from 6.81% in July 2023 to a peak of 22.37% in March 2024, eventually returning to 8.15%. The correlation between these returns and the net profit margin, without a corresponding spike in operating margin, indicates that these gains were likely driven by non-operating income or structural balance sheet changes rather than core business growth.
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Gross Profit Margin
| Sep 27, 2026 | Jun 28, 2026 | Mar 29, 2026 | Dec 28, 2025 | Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 29, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Gross profit | 17,302) | 17,259) | 15,956) | 16,596) | 16,690) | 16,115) | 14,536) | 15,392) | 15,508) | 15,578) | 14,872) | 14,597) | 14,745) | 15,057) | 14,207) | 15,941) | 15,984) | 16,101) | 15,828) | ||||||
| Sales to customers | 25,399) | 25,310) | 24,062) | 24,564) | 23,993) | 23,743) | 21,893) | 22,520) | 22,471) | 22,447) | 21,383) | 21,395) | 21,351) | 21,519) | 20,894) | 23,706) | 23,791) | 24,020) | 23,426) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Gross profit margin1 | 67.56% | 67.91% | 67.82% | 67.88% | 68.08% | 67.92% | 68.30% | 69.07% | 69.05% | 69.06% | 69.20% | 68.82% | 68.54% | 68.06% | 67.34% | 67.26% | 67.43% | 67.86% | 67.97% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Gross Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 73.72% | 71.48% | 70.68% | 70.24% | 69.74% | 70.93% | 70.69% | 69.99% | 67.21% | 62.75% | 62.28% | 62.42% | 65.76% | 68.91% | 69.43% | 70.00% | 69.62% | 70.48% | 69.53% | ||||||
| Amgen Inc. | — | 67.97% | 66.72% | 65.75% | 64.71% | 62.99% | 61.48% | 59.85% | 58.71% | 61.56% | 64.76% | 68.60% | 72.35% | 72.87% | 73.65% | 74.17% | 73.99% | 74.00% | 73.30% | ||||||
| Bristol-Myers Squibb Co. | 69.24% | 70.16% | 70.46% | 71.08% | 69.50% | 70.29% | 70.47% | 71.08% | 74.91% | 75.38% | 75.71% | 76.24% | 76.54% | 77.01% | 77.68% | 78.04% | 78.82% | 79.13% | 79.62% | ||||||
| Danaher Corp. | 58.59% | 58.51% | 58.94% | 59.11% | 59.53% | 59.66% | 59.74% | 59.50% | 59.37% | 59.27% | 58.39% | 58.74% | 58.77% | 59.17% | 60.22% | 60.21% | 60.65% | 60.77% | 60.77% | ||||||
| Eli Lilly & Co. | 83.63% | 83.40% | 82.83% | 83.04% | 83.03% | 82.64% | 81.70% | 81.31% | 80.91% | 80.75% | 80.16% | 79.25% | 78.67% | 77.77% | 77.67% | 76.77% | 75.61% | 75.98% | 74.40% | ||||||
| Gilead Sciences Inc. | 79.79% | 79.15% | 79.01% | 78.44% | 78.31% | 78.42% | 78.17% | 78.15% | 75.98% | 75.56% | 75.62% | 75.87% | 78.66% | 79.27% | 78.94% | 79.03% | 74.31% | 75.30% | 75.50% | ||||||
| Merck & Co. Inc. | — | 72.97% | 73.91% | 74.80% | 77.18% | 76.60% | 76.42% | 76.32% | 75.82% | 75.25% | 74.37% | 73.17% | 72.86% | 72.96% | 72.43% | 70.63% | 70.49% | 70.41% | 70.72% | ||||||
| Pfizer Inc. | 73.38% | 73.18% | 73.51% | 74.33% | 73.39% | 72.12% | 72.28% | 71.94% | 67.73% | 58.18% | 58.09% | 58.10% | 60.97% | 69.61% | 68.61% | 65.77% | 65.53% | 62.18% | 60.35% | ||||||
| Regeneron Pharmaceuticals Inc. | 85.77% | 84.86% | 84.55% | 85.35% | 85.39% | 85.57% | 85.79% | 86.13% | 86.12% | 86.16% | 86.32% | 86.16% | 85.96% | 86.42% | 86.96% | 87.18% | 85.39% | 84.97% | 84.65% | ||||||
| Thermo Fisher Scientific Inc. | 41.08% | 40.80% | 40.78% | 40.93% | 41.27% | 41.18% | 41.34% | 41.28% | 40.77% | 40.76% | 40.40% | 39.90% | 39.87% | 39.75% | 40.28% | 42.24% | 44.42% | 46.63% | 48.37% | ||||||
| Vertex Pharmaceuticals Inc. | 85.53% | 86.00% | 86.24% | 86.24% | 86.28% | 86.11% | 86.03% | 86.11% | 86.12% | 86.45% | 86.86% | 87.21% | 87.80% | 87.92% | 88.04% | 87.90% | 88.00% | 88.13% | 87.95% | ||||||
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
1 Q3 2026 Calculation
Gross profit margin = 100
× (Gross profitQ3 2026
+ Gross profitQ2 2026
+ Gross profitQ1 2026
+ Gross profitQ4 2025)
÷ (Sales to customersQ3 2026
+ Sales to customersQ2 2026
+ Sales to customersQ1 2026
+ Sales to customersQ4 2025)
= 100 × (17,302 + 17,259 + 15,956 + 16,596)
÷ (25,399 + 25,310 + 24,062 + 24,564)
= 67.56%
2 Click competitor name to see calculations.
The gross profit margin exhibits a period of moderate volatility between April 2022 and September 2026, fluctuating within a narrow range between 67.26% and 69.20%. A notable inverse relationship is observed between sales volume and margin percentages during the 2023 period, followed by a stabilization phase as revenue grew to new peaks in 2025 and 2026.
- Revenue and Profitability Correlation
- Sales to customers experienced a significant contraction starting in April 2023, dropping from previous levels of approximately $23-24 billion to a low of $20.89 billion. Despite this decline in top-line revenue, the gross profit margin trended upward during the same interval, rising from 67.34% in April 2023 to a peak of 69.20% by March 2024. This divergence suggests that profitability per unit increased or the product mix shifted toward higher-margin offerings during the period of lower sales volume.
- Margin Peak and Normalization
- The highest efficiency in gross profit generation occurred between June 2023 and December 2024, where margins consistently remained at or above 68%. A subsequent correction is observed starting in March 2025, with the margin returning to a baseline range of 67.56% to 68.08%. This normalization coincided with a steady recovery and expansion of sales, which grew from $21.89 billion in December 2024 to $25.40 billion by September 2026.
- Long-term Trend Analysis
- Over the analyzed timeframe, the gross profit margin demonstrates high stability, never deviating more than 2% from its mean. The capacity to maintain margins near 68% while scaling sales from $21 billion back to over $25 billion indicates a robust cost management structure and consistent pricing power across different volume cycles.
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Operating Profit Margin
| Sep 27, 2026 | Jun 28, 2026 | Mar 29, 2026 | Dec 28, 2025 | Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 29, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Operating earnings | 5,845) | 7,140) | 6,327) | 5,426) | 7,033) | 6,646) | 6,182) | 3,582) | 5,037) | 6,276) | 5,909) | 4,193) | 5,534) | 5,813) | 5,667) | 5,331) | 6,216) | 6,087) | 5,748) | ||||||
| Sales to customers | 25,399) | 25,310) | 24,062) | 24,564) | 23,993) | 23,743) | 21,893) | 22,520) | 22,471) | 22,447) | 21,383) | 21,395) | 21,351) | 21,519) | 20,894) | 23,706) | 23,791) | 24,020) | 23,426) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Operating profit margin1 | 24.90% | 26.47% | 26.39% | 26.85% | 25.44% | 23.67% | 23.59% | 23.42% | 24.42% | 25.31% | 25.04% | 24.90% | 25.55% | 25.61% | 25.21% | 24.63% | 23.89% | 23.47% | 23.76% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Operating Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 32.16% | 26.20% | 24.41% | 24.65% | 15.16% | 18.80% | 17.56% | 16.22% | 24.89% | 22.31% | 23.50% | 23.49% | 27.32% | 31.03% | 28.49% | 31.21% | 30.59% | 30.33% | 32.68% | ||||||
| Amgen Inc. | — | 31.51% | 29.77% | 25.83% | 25.14% | 24.45% | 22.71% | 22.66% | 19.97% | 20.96% | 24.72% | 29.35% | 34.55% | 37.50% | 36.07% | 38.57% | 39.31% | 38.04% | 32.78% | ||||||
| Bristol-Myers Squibb Co. | 23.10% | 23.83% | 20.55% | 20.75% | 18.86% | 16.70% | 15.24% | -15.50% | -14.05% | -14.39% | -14.30% | 16.18% | 16.96% | 17.29% | 18.13% | 17.96% | 19.04% | 18.19% | 16.79% | ||||||
| Danaher Corp. | 20.38% | 20.42% | 19.21% | 19.09% | 19.01% | 18.39% | 20.26% | 20.37% | 20.11% | 21.22% | 21.05% | 21.77% | 23.83% | 25.06% | 27.02% | 27.61% | 27.35% | 25.44% | 25.23% | ||||||
| Eli Lilly & Co. | 40.34% | 42.22% | 43.63% | 40.35% | 38.84% | 32.37% | 28.74% | 28.64% | 24.81% | 23.28% | 20.80% | 18.92% | 18.42% | 24.17% | 22.45% | 24.97% | 24.65% | 25.50% | 25.94% | ||||||
| Gilead Sciences Inc. | -7.68% | -8.37% | 35.46% | 34.66% | 36.75% | 28.03% | 28.77% | 5.81% | 2.92% | 9.26% | 5.79% | 28.24% | 30.37% | 31.18% | 33.03% | 27.17% | 22.39% | 25.78% | 26.56% | ||||||
| Merck & Co. Inc. | — | 9.58% | 18.18% | 32.64% | 33.73% | 30.00% | 31.51% | 31.03% | 21.60% | 24.75% | 6.93% | 3.92% | 13.08% | 10.34% | 27.85% | 30.27% | 30.66% | 33.04% | 28.85% | ||||||
| Pfizer Inc. | 21.44% | 21.70% | 22.96% | 22.76% | 21.85% | 23.23% | 19.29% | 19.51% | 9.56% | -4.19% | -2.08% | 2.15% | 14.36% | 28.13% | 34.44% | 34.83% | 33.59% | 30.37% | 26.12% | ||||||
| Regeneron Pharmaceuticals Inc. | 28.79% | 24.74% | 24.32% | 24.95% | 25.89% | 27.02% | 27.20% | 28.10% | 28.69% | 28.95% | 29.40% | 30.85% | 32.23% | 34.20% | 35.79% | 38.93% | 45.45% | 48.19% | 55.08% | ||||||
| Thermo Fisher Scientific Inc. | 17.88% | 17.58% | 17.46% | 17.38% | 17.16% | 17.13% | 17.23% | 17.11% | 16.93% | 17.01% | 16.38% | 16.00% | 15.81% | 15.42% | 16.29% | 18.69% | 20.54% | 22.51% | 23.83% | ||||||
| Vertex Pharmaceuticals Inc. | 33.23% | 37.95% | 38.31% | 34.77% | 34.06% | 34.36% | -6.69% | -2.11% | -2.54% | -3.37% | 41.16% | 38.83% | 40.16% | 41.72% | 43.93% | 48.23% | 47.72% | 48.85% | 36.93% | ||||||
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
1 Q3 2026 Calculation
Operating profit margin = 100
× (Operating earningsQ3 2026
+ Operating earningsQ2 2026
+ Operating earningsQ1 2026
+ Operating earningsQ4 2025)
÷ (Sales to customersQ3 2026
+ Sales to customersQ2 2026
+ Sales to customersQ1 2026
+ Sales to customersQ4 2025)
= 100 × (5,845 + 7,140 + 6,327 + 5,426)
÷ (25,399 + 25,310 + 24,062 + 24,564)
= 24.90%
2 Click competitor name to see calculations.
The operational efficiency of the entity exhibits a cyclical pattern of expansion and contraction from April 2022 through September 2026. The operating profit margin fluctuates within a range of 23.42% to 26.85%, indicating a general trend of resilience with periodic volatility in cost management and revenue conversion.
- Initial Margin Expansion (2022–2023)
- A steady upward trajectory is observed from April 2022, where the margin stood at 23.76%, rising to a peak of 25.61% by July 2023. This period reflects a consistent increase in profitability relative to sales, as operating earnings grew from 5.748 billion US dollars to 5.813 billion US dollars during a period of fluctuating sales volumes.
- Operational Contraction and Trough (2024)
- A notable decline in efficiency occurred throughout 2024, with the margin reaching its lowest point of 23.42% on December 29, 2024. This contraction coincides with the lowest recorded quarterly operating earnings of 3.582 billion US dollars, despite sales remaining relatively stable at 22.520 billion US dollars, suggesting a significant increase in operating expenses during the latter half of the year.
- Efficiency Peak and Stabilization (2025–2026)
- A robust recovery is evident in 2025, leading to the highest observed margin of 26.85% on December 28, 2025. This peak indicates a period of optimized operational performance and enhanced cost control. While the margin remained elevated throughout the first half of 2026, peaking again at 26.47% in June, a subsequent correction occurred, bringing the margin back to 24.90% by September 2026.
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Net Profit Margin
| Sep 27, 2026 | Jun 28, 2026 | Mar 29, 2026 | Dec 28, 2025 | Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 29, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net earnings (loss) | 210) | 5,534) | 5,235) | 5,116) | 5,152) | 5,537) | 10,999) | 3,431) | 2,694) | 4,686) | 3,255) | 4,049) | 26,028) | 5,144) | (68) | 3,520) | 4,458) | 4,814) | 5,149) | ||||||
| Sales to customers | 25,399) | 25,310) | 24,062) | 24,564) | 23,993) | 23,743) | 21,893) | 22,520) | 22,471) | 22,447) | 21,383) | 21,395) | 21,351) | 21,519) | 20,894) | 23,706) | 23,791) | 24,020) | 23,426) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| Net profit margin1 | 16.20% | 21.48% | 21.83% | 28.46% | 27.26% | 25.00% | 24.41% | 15.84% | 16.74% | 43.91% | 44.92% | 41.28% | 39.58% | 14.52% | 13.77% | 18.90% | 19.95% | 19.21% | 20.90% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| Net Profit Margin, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 15.67% | 9.80% | 5.79% | 6.91% | 4.00% | 6.45% | 7.31% | 7.59% | 9.22% | 9.71% | 11.02% | 8.95% | 11.81% | 15.50% | 13.37% | 20.39% | 23.19% | 22.04% | 22.00% | ||||||
| Amgen Inc. | — | 24.11% | 21.98% | 21.94% | 20.31% | 19.75% | 18.10% | 12.77% | 13.58% | 10.60% | 13.35% | 24.96% | 29.52% | 31.52% | 31.77% | 26.42% | 27.88% | 26.73% | 23.42% | ||||||
| Bristol-Myers Squibb Co. | 18.47% | 18.87% | 15.01% | 14.64% | 12.57% | 10.58% | 11.38% | -18.53% | -15.30% | -14.06% | -13.50% | 17.83% | 18.44% | 17.62% | 15.95% | 13.71% | 14.29% | 14.04% | 13.31% | ||||||
| Danaher Corp. | 16.91% | 15.95% | 14.89% | 14.71% | 14.43% | 14.21% | 15.81% | 16.33% | 16.39% | 17.83% | 18.54% | 19.94% | 22.89% | 22.80% | 23.32% | 22.91% | 21.65% | 20.61% | 21.32% | ||||||
| Eli Lilly & Co. | 31.90% | 33.53% | 34.99% | 31.67% | 30.99% | 25.91% | 22.66% | 23.51% | 20.48% | 18.86% | 17.08% | 15.36% | 15.55% | 22.01% | 20.54% | 21.88% | 20.63% | 19.58% | 20.90% | ||||||
| Gilead Sciences Inc. | -12.56% | -10.86% | 31.51% | 29.43% | 28.41% | 21.98% | 20.87% | 1.68% | 0.45% | 3.82% | 1.78% | 21.03% | 21.60% | 20.18% | 20.87% | 17.02% | 12.44% | 15.22% | 16.60% | ||||||
| Merck & Co. Inc. | — | 4.77% | 13.59% | 28.08% | 29.63% | 25.79% | 27.27% | 26.68% | 19.23% | 21.98% | 3.76% | 0.61% | 7.77% | 5.34% | 22.52% | 24.49% | 25.88% | 29.00% | 26.27% | ||||||
| Pfizer Inc. | 6.34% | 6.80% | 11.83% | 12.42% | 15.65% | 16.84% | 12.62% | 12.62% | 7.04% | -4.62% | -0.55% | 3.56% | 15.13% | 27.38% | 31.19% | 31.27% | 29.81% | 28.94% | 27.01% | ||||||
| Regeneron Pharmaceuticals Inc. | 28.51% | 27.86% | 29.65% | 31.41% | 32.13% | 31.37% | 31.94% | 31.07% | 33.61% | 32.04% | 29.45% | 30.14% | 30.47% | 33.93% | 33.81% | 35.64% | 39.17% | 39.97% | 48.06% | ||||||
| Thermo Fisher Scientific Inc. | 14.94% | 15.04% | 15.15% | 15.05% | 15.02% | 15.23% | 15.18% | 14.77% | 14.48% | 14.69% | 14.20% | 13.99% | 13.68% | 13.14% | 13.75% | 15.47% | 15.92% | 17.37% | 18.49% | ||||||
| Vertex Pharmaceuticals Inc. | 30.70% | 35.00% | 35.51% | 32.94% | 31.35% | 31.86% | -8.91% | -4.86% | -4.52% | -4.74% | 39.46% | 36.68% | 35.94% | 35.40% | 35.40% | 37.20% | 37.62% | 38.26% | 30.84% | ||||||
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
1 Q3 2026 Calculation
Net profit margin = 100
× (Net earnings (loss)Q3 2026
+ Net earnings (loss)Q2 2026
+ Net earnings (loss)Q1 2026
+ Net earnings (loss)Q4 2025)
÷ (Sales to customersQ3 2026
+ Sales to customersQ2 2026
+ Sales to customersQ1 2026
+ Sales to customersQ4 2025)
= 100 × (210 + 5,534 + 5,235 + 5,116)
÷ (25,399 + 25,310 + 24,062 + 24,564)
= 16.20%
2 Click competitor name to see calculations.
The analyzed period is characterized by substantial volatility in net profit margins, shifting from a baseline of approximately 19% to extreme peaks and subsequent corrections. While sales to customers exhibited a gradual upward trajectory, net earnings fluctuated significantly, suggesting the influence of non-recurring items or significant operational adjustments affecting the bottom line.
- Profitability Margin Trends
- A period of extreme expansion is observed between October 2023 and June 2024, where the net profit margin surged from 39.58% to a peak of 44.92%. This peak represents a significant deviation from the margins observed in 2022. This expansion was followed by a sharp contraction in the second half of 2024, with margins falling to a low of 15.84% by December 29, 2024.
- Revenue Stability
- Sales remained relatively resilient, starting at 23,426 million US$ in April 2022 and increasing to 25,399 million US$ by September 2026. The steady nature of revenue growth indicates that the volatility in net profit margins is primarily driven by fluctuations in net earnings rather than unstable sales volume.
- Net Earnings Fluctuations
- Net earnings exhibited irregular patterns, including a deficit in April 2023 and a substantial spike to 26,028 million US$ in October 2023. The final recorded quarter in September 2026 shows a significant decline in earnings to 210 million US$, which correlates with a compressed net profit margin of 16.20%.
- Recovery and Final Decline Phase
- Following the contraction in late 2024, a recovery phase is observed from March 2025 through December 2025, during which margins climbed steadily from 24.41% to 28.46%. However, a downward trend resumed throughout 2026, ending the period with a reduction in overall profitability.
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Return on Equity (ROE)
| Sep 27, 2026 | Jun 28, 2026 | Mar 29, 2026 | Dec 28, 2025 | Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 29, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net earnings (loss) | 210) | 5,534) | 5,235) | 5,116) | 5,152) | 5,537) | 10,999) | 3,431) | 2,694) | 4,686) | 3,255) | 4,049) | 26,028) | 5,144) | (68) | 3,520) | 4,458) | 4,814) | 5,149) | ||||||
| Total Johnson & Johnson shareholders’ equity | 81,529) | 84,971) | 81,186) | 81,544) | 79,277) | 78,473) | 78,109) | 71,490) | 70,158) | 71,538) | 70,020) | 68,774) | 71,228) | 75,149) | 70,869) | 76,804) | 74,599) | 76,357) | 74,709) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROE1 | 19.74% | 24.76% | 25.92% | 32.87% | 31.69% | 28.88% | 27.92% | 19.68% | 20.93% | 53.14% | 54.95% | 51.11% | 48.61% | 17.37% | 17.95% | 23.36% | 25.68% | 24.05% | 26.54% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROE, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | — | — | — | — | — | — | 295.42% | 128.66% | 84.91% | 78.77% | 74.85% | 46.94% | 53.86% | 67.50% | 57.14% | 68.60% | 83.83% | 86.24% | 76.64% | ||||||
| Amgen Inc. | — | 74.80% | 84.87% | 89.06% | 72.82% | 89.11% | 95.59% | 69.59% | 56.20% | 52.83% | 74.93% | 107.78% | 98.82% | 117.67% | 148.04% | 178.97% | 187.11% | 271.85% | 624.78% | ||||||
| Bristol-Myers Squibb Co. | 39.49% | 41.59% | 36.25% | 38.19% | 32.55% | 28.96% | 31.16% | -54.78% | -42.34% | -38.44% | -37.28% | 27.27% | 28.57% | 24.91% | 22.97% | 20.37% | 20.44% | 20.30% | 19.79% | ||||||
| Danaher Corp. | 8.08% | 7.61% | 6.97% | 6.88% | 6.86% | 6.52% | 7.40% | 7.87% | 7.59% | 8.42% | 8.24% | 8.91% | 11.29% | 12.30% | 13.47% | 14.39% | 14.40% | 13.63% | 13.93% | ||||||
| Eli Lilly & Co. | 68.49% | 78.84% | 81.02% | 77.78% | 77.38% | 75.52% | 70.45% | 74.62% | 58.78% | 54.14% | 47.91% | 48.65% | 44.46% | 58.73% | 50.82% | 58.64% | 59.91% | 66.61% | 65.69% | ||||||
| Gilead Sciences Inc. | -29.62% | -27.39% | 39.19% | 37.48% | 37.65% | 32.08% | 31.13% | 2.48% | 0.69% | 5.77% | 2.77% | 24.81% | 26.33% | 25.92% | 26.59% | 21.62% | 15.82% | 20.44% | 22.66% | ||||||
| Merck & Co. Inc. | — | 7.57% | 19.48% | 34.70% | 36.71% | 33.49% | 36.07% | 36.96% | 27.30% | 31.52% | 5.71% | 0.97% | 11.17% | 8.04% | 27.82% | 31.57% | 34.32% | 38.34% | 34.68% | ||||||
| Pfizer Inc. | 4.53% | 5.09% | 8.31% | 8.99% | 10.59% | 12.12% | 8.73% | 9.11% | 4.61% | -2.96% | -0.33% | 2.38% | 10.81% | 21.68% | 28.77% | 32.79% | 32.14% | 33.61% | 30.29% | ||||||
| Regeneron Pharmaceuticals Inc. | 14.38% | 13.65% | 14.08% | 14.41% | 14.79% | 14.89% | 15.31% | 15.03% | 15.87% | 15.32% | 14.29% | 15.22% | 16.03% | 17.90% | 17.80% | 19.14% | 25.05% | 27.49% | 39.84% | ||||||
| Thermo Fisher Scientific Inc. | 12.91% | 13.23% | 13.19% | 12.55% | 12.88% | 13.03% | 13.19% | 12.78% | 12.52% | 13.12% | 13.26% | 12.83% | 13.11% | 13.08% | 14.26% | 15.80% | 16.15% | 17.59% | 18.56% | ||||||
| Vertex Pharmaceuticals Inc. | 19.02% | 21.76% | 22.41% | 21.18% | 21.22% | 21.18% | -5.99% | -3.26% | -3.07% | -3.32% | 21.67% | 20.59% | 21.01% | 21.75% | 22.59% | 23.88% | 25.12% | 26.77% | 22.47% | ||||||
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
1 Q3 2026 Calculation
ROE = 100
× (Net earnings (loss)Q3 2026
+ Net earnings (loss)Q2 2026
+ Net earnings (loss)Q1 2026
+ Net earnings (loss)Q4 2025)
÷ Total Johnson & Johnson shareholders’ equity
= 100 × (210 + 5,534 + 5,235 + 5,116)
÷ 81,529 = 19.74%
2 Click competitor name to see calculations.
The analysis of the Return on Equity (ROE) from April 2022 through September 2026 reveals a period of significant volatility, primarily driven by extreme fluctuations in quarterly net earnings rather than steady changes in shareholders' equity.
- Earnings Volatility and ROE Spikes
- A pronounced instability in net earnings is observed, which directly impacts the ROE. The most significant anomaly occurred between October 2023 and March 2024, where ROE surged from 48.61% to a peak of 54.95%. This spike correlates with a quarterly net earnings peak of 26,028 million USD in October 2023. A subsequent secondary peak in ROE reached 32.87% in December 2024, coinciding with net earnings of 10,999 million USD in March 2025.
- Shareholders' Equity Trends
- Shareholders' equity demonstrated a general upward trajectory over the analyzed period. After reaching a low of 68,774 million USD in December 2023, equity grew steadily to a peak of 84,971 million USD by March 2026. This gradual expansion of the equity base acted as a moderating factor on ROE during periods of stable earnings, though it was insufficient to offset the impact of extreme earnings volatility.
- Recent Performance Degradation
- A downward trend in profitability is evident toward the end of the sequence. ROE declined from 25.92% in March 2026 to 19.74% by September 2026. This contraction is directly attributable to a sharp decline in net earnings, which fell to 210 million USD in the final quarter, the lowest positive earnings figure in the provided period.
- Comparative Stability Periods
- Relatively stable ROE levels were observed during the 2022 calendar year, fluctuating within a narrow range between 23.36% and 26.54%. This stability contrasted sharply with the 2023-2025 period, which was characterized by erratic swings resulting from non-linear earnings patterns.
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Return on Assets (ROA)
| Sep 27, 2026 | Jun 28, 2026 | Mar 29, 2026 | Dec 28, 2025 | Sep 28, 2025 | Jun 29, 2025 | Mar 30, 2025 | Dec 29, 2024 | Sep 29, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Oct 1, 2023 | Jul 2, 2023 | Apr 2, 2023 | Dec 31, 2022 | Oct 2, 2022 | Jul 3, 2022 | Apr 3, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | |||||||||||||||||||||||||
| Net earnings (loss) | 210) | 5,534) | 5,235) | 5,116) | 5,152) | 5,537) | 10,999) | 3,431) | 2,694) | 4,686) | 3,255) | 4,049) | 26,028) | 5,144) | (68) | 3,520) | 4,458) | 4,814) | 5,149) | ||||||
| Total assets | 197,425) | 201,061) | 200,894) | 199,210) | 192,816) | 193,389) | 193,671) | 180,104) | 178,287) | 181,088) | 171,966) | 167,558) | 166,061) | 191,686) | 195,969) | 187,378) | 175,124) | 177,724) | 178,355) | ||||||
| Profitability Ratio | |||||||||||||||||||||||||
| ROA1 | 8.15% | 10.46% | 10.47% | 13.46% | 13.03% | 11.72% | 11.26% | 7.81% | 8.24% | 20.99% | 22.37% | 20.98% | 20.85% | 6.81% | 6.49% | 9.57% | 10.94% | 10.33% | 11.12% | ||||||
| Benchmarks | |||||||||||||||||||||||||
| ROA, Competitors2 | |||||||||||||||||||||||||
| AbbVie Inc. | 7.00% | 4.67% | 2.66% | 3.15% | 1.78% | 2.74% | 3.08% | 3.17% | 3.57% | 3.76% | 4.03% | 3.61% | 4.78% | 6.42% | 5.64% | 8.53% | 9.49% | 8.83% | 8.71% | ||||||
| Amgen Inc. | — | 9.14% | 8.43% | 8.51% | 7.77% | 7.53% | 6.64% | 4.45% | 4.65% | 3.44% | 4.05% | 6.91% | 8.36% | 8.84% | 8.92% | 10.06% | 10.73% | 11.09% | 9.67% | ||||||
| Bristol-Myers Squibb Co. | 10.41% | 10.59% | 8.41% | 7.83% | 6.23% | 5.33% | 5.86% | -9.66% | -7.75% | -6.91% | -6.21% | 8.43% | 9.08% | 8.52% | 7.75% | 6.53% | 6.80% | 6.59% | 6.07% | ||||||
| Danaher Corp. | 4.64% | 4.33% | 4.42% | 4.33% | 4.38% | 4.18% | 4.76% | 5.03% | 4.83% | 5.35% | 5.28% | 5.64% | 6.74% | 7.49% | 8.15% | 8.55% | 8.35% | 7.76% | 7.74% | ||||||
| Eli Lilly & Co. | 18.63% | 18.77% | 21.68% | 18.35% | 16.02% | 13.67% | 12.42% | 13.45% | 11.07% | 10.22% | 9.60% | 8.19% | 8.61% | 11.85% | 10.70% | 12.62% | 12.71% | 12.09% | 13.06% | ||||||
| Gilead Sciences Inc. | -7.51% | -6.56% | 16.38% | 14.42% | 13.86% | 11.33% | 10.57% | 0.81% | 0.23% | 1.97% | 0.86% | 9.12% | 9.42% | 8.80% | 9.02% | 7.27% | 5.33% | 6.58% | 7.16% | ||||||
| Merck & Co. Inc. | — | 2.44% | 6.94% | 13.34% | 14.69% | 13.96% | 15.14% | 14.62% | 10.34% | 12.20% | 2.18% | 0.34% | 4.32% | 2.98% | 12.09% | 13.30% | 14.25% | 15.48% | 13.29% | ||||||
| Pfizer Inc. | 1.97% | 2.15% | 3.61% | 3.73% | 4.71% | 5.22% | 3.79% | 3.76% | 1.94% | -1.20% | -0.14% | 0.94% | 4.87% | 9.75% | 14.85% | 15.91% | 15.32% | 15.01% | 13.58% | ||||||
| Regeneron Pharmaceuticals Inc. | 10.85% | 10.37% | 10.82% | 11.11% | 11.40% | 11.67% | 11.98% | 11.69% | 12.43% | 11.98% | 11.22% | 11.95% | 12.41% | 14.02% | 13.91% | 14.85% | 19.40% | 20.90% | 30.11% | ||||||
| Thermo Fisher Scientific Inc. | 6.19% | 6.16% | 6.05% | 6.08% | 6.38% | 6.50% | 6.58% | 6.51% | 6.11% | 6.32% | 6.21% | 6.07% | 6.12% | 6.08% | 6.36% | 7.15% | 7.77% | 8.21% | 8.20% | ||||||
| Vertex Pharmaceuticals Inc. | 12.15% | 16.06% | 16.38% | 15.42% | 14.78% | 15.13% | -4.32% | -2.38% | -2.16% | -2.43% | 16.81% | 15.92% | 15.97% | 16.54% | 17.18% | 18.30% | 19.59% | 20.50% | 17.19% | ||||||
Based on: 10-Q (reporting date: 2026-09-27), 10-Q (reporting date: 2026-06-28), 10-Q (reporting date: 2026-03-29), 10-K (reporting date: 2025-12-28), 10-Q (reporting date: 2025-09-28), 10-Q (reporting date: 2025-06-29), 10-Q (reporting date: 2025-03-30), 10-K (reporting date: 2024-12-29), 10-Q (reporting date: 2024-09-29), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-10-01), 10-Q (reporting date: 2023-07-02), 10-Q (reporting date: 2023-04-02), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-10-02), 10-Q (reporting date: 2022-07-03), 10-Q (reporting date: 2022-04-03).
1 Q3 2026 Calculation
ROA = 100
× (Net earnings (loss)Q3 2026
+ Net earnings (loss)Q2 2026
+ Net earnings (loss)Q1 2026
+ Net earnings (loss)Q4 2025)
÷ Total assets
= 100 × (210 + 5,534 + 5,235 + 5,116)
÷ 197,425 = 8.15%
2 Click competitor name to see calculations.
The return on assets (ROA) exhibits significant volatility over the analyzed period, characterized by a severe contraction in early 2023, a substantial peak in late 2023 and early 2024, and a subsequent stabilization phase followed by a decline in 2026.
- Initial Stability and Contraction
- Between April 2022 and December 2022, ROA remained relatively stable, fluctuating between 9.57% and 11.12%. A sharp decline occurred in April 2023, where ROA dropped to 6.49%, coinciding with a quarterly net loss of 68 million US dollars.
- Peak Profitability and Anomalies
- A dramatic increase in profitability is observed starting in October 2023, with ROA surging to 20.85% and reaching a peak of 22.37% by March 31, 2024. This spike was primarily driven by a substantial increase in net earnings, which reached 26,028 million US dollars in October 2023, while total assets simultaneously contracted to a period low of 166,061 million US dollars.
- Correction and Recovery Phase
- Following the peak, ROA underwent a sharp correction, falling to 7.81% by December 29, 2024. A recovery phase followed throughout 2025, with the ratio climbing from 11.26% in March to 13.46% in December 2025, reflecting a steady alignment of net earnings and asset growth.
- Recent Downward Trend
- During the first three quarters of 2026, a downward trajectory is evident. ROA decreased from 10.47% in March to 8.15% by September 27, 2026. This decline occurs despite total assets remaining near historical highs, ending the period at 197,425 million US dollars, indicating a reduction in the efficiency of asset utilization to generate earnings.
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