Analysis of Profitability Ratios
Quarterly Data
Profitability ratios measure the company ability to generate profitable sales from its resources (assets).
Profitability Ratios (Summary)
Gilead Sciences Inc., profitability ratios (quarterly data)
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
The profitability profile exhibits a pattern of relative stability in gross margins contrasted by significant volatility in operating and net margins, culminating in a sharp reversal in the final reported quarter.
- Gross Profit Margin
- The gross profit margin remained consistently high, fluctuating within a narrow range between 74.31% and 79.15%. This stability suggests a consistent ability to manage direct production costs relative to revenue over the analyzed period, with a slight upward trend observed toward the end of the period.
- Operating and Net Profit Margins
- Operating and net profit margins experienced extreme volatility. After a period of relative strength between 2022 and 2023, both metrics saw a severe compression throughout 2024, with the net profit margin reaching a low of 0.45% in September 2024. A strong recovery followed in 2025, with net profit margins peaking at 31.51% by March 2026. However, a sudden and sharp decline occurred in June 2026, with the operating profit margin falling to -8.37% and the net profit margin dropping to -10.86%.
- Return on Equity (ROE) and Return on Assets (ROA)
- Return metrics mirrored the fluctuations seen in net profitability. ROE and ROA both declined sharply in 2024, nearly reaching zero. These metrics then entered a phase of significant expansion throughout 2025 and early 2026, with ROE reaching a peak of 39.19% and ROA reaching 16.38% in March 2026. This growth was abruptly reversed in June 2026, as ROE plummeted to -27.39% and ROA fell to -6.56%.
The divergence between the stable gross profit margin and the highly volatile operating and net margins indicates that the fluctuations in bottom-line profitability were driven by operating expenses, non-operating items, or one-time charges rather than changes in the core cost of goods sold.
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Return on Sales
Return on Investment
Gross Profit Margin
Gilead Sciences Inc., gross profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Gross profit on product sales | 6,048) | 5,501) | 6,279) | 5,776) | 5,553) | 5,073) | 5,955) | 5,941) | 5,368) | 5,095) | 4,980) | 5,429) | 5,122) | 4,905) | 5,936) | 5,583) | 4,696) | 5,110) | ||||||
| Product sales | 7,627) | 6,946) | 7,903) | 7,345) | 7,054) | 6,613) | 7,536) | 7,515) | 6,912) | 6,647) | 7,070) | 6,994) | 6,564) | 6,306) | 7,332) | 6,978) | 6,138) | 6,534) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Gross profit margin1 | 79.15% | 79.01% | 78.44% | 78.31% | 78.42% | 78.17% | 78.15% | 75.98% | 75.56% | 75.62% | 75.87% | 78.66% | 79.27% | 78.94% | 79.03% | 74.31% | 75.30% | 75.50% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Gross Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 71.48% | 70.68% | 70.24% | 69.74% | 70.93% | 70.69% | 69.99% | 67.21% | 62.75% | 62.28% | 62.42% | 65.76% | 68.91% | 69.43% | 70.00% | 69.62% | 70.48% | 69.53% | ||||||
| Amgen Inc. | 67.97% | 66.72% | 65.75% | 64.71% | 62.99% | 61.48% | 59.85% | 58.71% | 61.56% | 64.76% | 68.60% | 72.35% | 72.87% | 73.65% | 74.17% | 73.99% | 74.00% | 73.30% | ||||||
| Bristol-Myers Squibb Co. | 70.16% | 70.46% | 71.08% | 69.50% | 70.29% | 70.47% | 71.08% | 74.91% | 75.38% | 75.71% | 76.24% | 76.54% | 77.01% | 77.68% | 78.04% | 78.82% | 79.13% | 79.62% | ||||||
| Danaher Corp. | 58.51% | 58.94% | 59.11% | 59.53% | 59.66% | 59.74% | 59.50% | 59.37% | 59.27% | 58.39% | 58.74% | 58.77% | 59.17% | 60.22% | 60.21% | 60.65% | 60.77% | 60.77% | ||||||
| Eli Lilly & Co. | 83.40% | 82.83% | 83.04% | 83.03% | 82.64% | 81.70% | 81.31% | 80.91% | 80.75% | 80.16% | 79.25% | 78.67% | 77.77% | 77.67% | 76.77% | 75.61% | 75.98% | 74.40% | ||||||
| Johnson & Johnson | 67.91% | 67.82% | 67.88% | 68.08% | 67.92% | 68.30% | 69.07% | 69.05% | 69.06% | 69.20% | 68.82% | 68.54% | 68.06% | 67.34% | 67.26% | 67.43% | 67.86% | 67.97% | ||||||
| Merck & Co. Inc. | 72.97% | 73.91% | 74.80% | 77.18% | 76.60% | 76.42% | 76.32% | 75.82% | 75.25% | 74.37% | 73.17% | 72.86% | 72.96% | 72.43% | 70.63% | 70.49% | 70.41% | 70.72% | ||||||
| Pfizer Inc. | 73.18% | 73.51% | 74.33% | 73.39% | 72.12% | 72.28% | 71.94% | 67.73% | 58.18% | 58.09% | 58.10% | 60.97% | 69.61% | 68.61% | 65.77% | 65.53% | 62.18% | 60.35% | ||||||
| Regeneron Pharmaceuticals Inc. | 84.86% | 84.55% | 85.35% | 85.39% | 85.57% | 85.79% | 86.13% | 86.12% | 86.16% | 86.32% | 86.16% | 85.96% | 86.42% | 86.96% | 87.18% | 85.39% | 84.97% | 84.65% | ||||||
| Thermo Fisher Scientific Inc. | 40.80% | 40.78% | 40.93% | 41.27% | 41.18% | 41.34% | 41.28% | 40.77% | 40.76% | 40.40% | 39.90% | 39.87% | 39.75% | 40.28% | 42.24% | 44.42% | 46.63% | 48.37% | ||||||
| Vertex Pharmaceuticals Inc. | 86.00% | 86.24% | 86.24% | 86.28% | 86.11% | 86.03% | 86.11% | 86.12% | 86.45% | 86.86% | 87.21% | 87.80% | 87.92% | 88.04% | 87.90% | 88.00% | 88.13% | 87.95% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Gross profit margin = 100
× (Gross profit on product salesQ2 2026
+ Gross profit on product salesQ1 2026
+ Gross profit on product salesQ4 2025
+ Gross profit on product salesQ3 2025)
÷ (Product salesQ2 2026
+ Product salesQ1 2026
+ Product salesQ4 2025
+ Product salesQ3 2025)
= 100 × (6,048 + 5,501 + 6,279 + 5,776)
÷ (7,627 + 6,946 + 7,903 + 7,345)
= 79.15%
2 Click competitor name to see calculations.
The analysis of profitability indicators reveals a general upward trajectory in both revenue and gross profit, accompanied by a fluctuating but ultimately recovering gross profit margin. Between March 2022 and June 2026, the company demonstrates a capacity for sustained growth in product sales, despite recurring quarterly volatility.
- Product Sales and Gross Profit Volume
- Product sales exhibit a cyclical pattern, with consistent declines typically observed in the first quarter of each year. Despite these seasonal dips, an overall growth trend is evident, with quarterly sales increasing from a range of 6,138 million to 7,332 million US dollars in 2022 to projected peaks of 7,903 million US dollars by December 2025. Gross profit on product sales mirrors this growth, rising from 5,110 million US dollars in March 2022 to a projected 6,048 million US dollars by June 2026.
- Gross Profit Margin Dynamics
- The gross profit margin displays significant variance, ranging from a minimum of 74.31% in September 2022 to a maximum of 79.27% in June 2023. A period of margin contraction is observed from September 2023 through June 2024, where the ratio settled between 75.56% and 78.66%. Following this period, a steady recovery is noted, with the margin climbing back toward the 78% to 79% range and remaining stable through the first half of 2026.
- Operational Profitability Patterns
- A decoupling is observed between sales volume and margin percentage. For instance, the highest margin recorded (79.27% in June 2023) did not coincide with the highest sales volume, suggesting that profitability is driven by shifts in product mix or cost management rather than purely by scaling revenue. The projected stability in the margin near 79% for 2026 suggests an expectation of optimized cost structures relative to sales growth.
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Operating Profit Margin
Gilead Sciences Inc., operating profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Operating income (loss) | (10,394) | 2,586) | 1,984) | 3,327) | 2,474) | 2,237) | 2,452) | 888) | 2,644) | (4,322) | 1,612) | 2,623) | 1,665) | 1,705) | 2,267) | 2,837) | 2,029) | 197) | ||||||
| Product sales | 7,627) | 6,946) | 7,903) | 7,345) | 7,054) | 6,613) | 7,536) | 7,515) | 6,912) | 6,647) | 7,070) | 6,994) | 6,564) | 6,306) | 7,332) | 6,978) | 6,138) | 6,534) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Operating profit margin1 | -8.37% | 35.46% | 34.66% | 36.75% | 28.03% | 28.77% | 5.81% | 2.92% | 9.26% | 5.79% | 28.24% | 30.37% | 31.18% | 33.03% | 27.17% | 22.39% | 25.78% | 26.56% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Operating Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 26.20% | 24.41% | 24.65% | 15.16% | 18.80% | 17.56% | 16.22% | 24.89% | 22.31% | 23.50% | 23.49% | 27.32% | 31.03% | 28.49% | 31.21% | 30.59% | 30.33% | 32.68% | ||||||
| Amgen Inc. | 31.51% | 29.77% | 25.83% | 25.14% | 24.45% | 22.71% | 22.66% | 19.97% | 20.96% | 24.72% | 29.35% | 34.55% | 37.50% | 36.07% | 38.57% | 39.31% | 38.04% | 32.78% | ||||||
| Bristol-Myers Squibb Co. | 23.83% | 20.55% | 20.75% | 18.86% | 16.70% | 15.24% | -15.50% | -14.05% | -14.39% | -14.30% | 16.18% | 16.96% | 17.29% | 18.13% | 17.96% | 19.04% | 18.19% | 16.79% | ||||||
| Danaher Corp. | 20.42% | 19.21% | 19.09% | 19.01% | 18.39% | 20.26% | 20.37% | 20.11% | 21.22% | 21.05% | 21.77% | 23.83% | 25.06% | 27.02% | 27.61% | 27.35% | 25.44% | 25.23% | ||||||
| Eli Lilly & Co. | 42.22% | 43.63% | 40.35% | 38.84% | 32.37% | 28.74% | 28.64% | 24.81% | 23.28% | 20.80% | 18.92% | 18.42% | 24.17% | 22.45% | 24.97% | 24.65% | 25.50% | 25.94% | ||||||
| Johnson & Johnson | 26.47% | 26.39% | 26.85% | 25.44% | 23.67% | 23.59% | 23.42% | 24.42% | 25.31% | 25.04% | 24.90% | 25.55% | 25.61% | 25.21% | 24.63% | 23.89% | 23.47% | 23.76% | ||||||
| Merck & Co. Inc. | 9.58% | 18.18% | 32.64% | 33.73% | 30.00% | 31.51% | 31.03% | 21.60% | 24.75% | 6.93% | 3.92% | 13.08% | 10.34% | 27.85% | 30.27% | 30.66% | 33.04% | 28.85% | ||||||
| Pfizer Inc. | 21.70% | 22.96% | 22.76% | 21.85% | 23.23% | 19.29% | 19.51% | 9.56% | -4.19% | -2.08% | 2.15% | 14.36% | 28.13% | 34.44% | 34.83% | 33.59% | 30.37% | 26.12% | ||||||
| Regeneron Pharmaceuticals Inc. | 24.74% | 24.32% | 24.95% | 25.89% | 27.02% | 27.20% | 28.10% | 28.69% | 28.95% | 29.40% | 30.85% | 32.23% | 34.20% | 35.79% | 38.93% | 45.45% | 48.19% | 55.08% | ||||||
| Thermo Fisher Scientific Inc. | 17.58% | 17.46% | 17.38% | 17.16% | 17.13% | 17.23% | 17.11% | 16.93% | 17.01% | 16.38% | 16.00% | 15.81% | 15.42% | 16.29% | 18.69% | 20.54% | 22.51% | 23.83% | ||||||
| Vertex Pharmaceuticals Inc. | 37.95% | 38.31% | 34.77% | 34.06% | 34.36% | -6.69% | -2.11% | -2.54% | -3.37% | 41.16% | 38.83% | 40.16% | 41.72% | 43.93% | 48.23% | 47.72% | 48.85% | 36.93% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Operating profit margin = 100
× (Operating income (loss)Q2 2026
+ Operating income (loss)Q1 2026
+ Operating income (loss)Q4 2025
+ Operating income (loss)Q3 2025)
÷ (Product salesQ2 2026
+ Product salesQ1 2026
+ Product salesQ4 2025
+ Product salesQ3 2025)
= 100 × (-10,394 + 2,586 + 1,984 + 3,327)
÷ (7,627 + 6,946 + 7,903 + 7,345)
= -8.37%
2 Click competitor name to see calculations.
The operating profit margin exhibits significant volatility over the observed period, characterized by cycles of expansion and abrupt, severe contractions. Despite relatively stable product sales, which fluctuated between approximately $6.1 billion and $7.9 billion, operating income showed extreme variance, leading to inconsistent profitability ratios.
- Margin Stability and Expansion (2022 - 2023)
- During 2022 and 2023, the operating profit margin remained generally strong, ranging from a low of 22.39% in September 2022 to a peak of 33.03% in March 2023. This period reflects a consistent ability to convert product sales into operating profit.
- Significant Volatility and Contraction (2024)
- A marked deterioration in profitability occurred throughout 2024. The margin dropped sharply to 5.79% in March 2024, coinciding with an operating loss of $4.322 billion, and reached a period low of 2.92% in September 2024. This indicates a substantial increase in operating expenses or one-time charges relative to revenue.
- Operational Recovery (2025)
- The first three quarters of 2025 saw a robust recovery, with margins returning to pre-2024 levels. Profitability peaked at 36.75% in September 2025, supported by an operating income of $3.327 billion, the highest value in the analyzed timeframe.
- Severe Decline (2026)
- The trend concludes with a sharp reversal in June 2026, where the operating profit margin fell to -8.37%. This decline was driven by a significant operating loss of $10.394 billion, representing the most severe contraction in operational profitability observed in the analyzed period.
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Net Profit Margin
Gilead Sciences Inc., net profit margin calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) attributable to Gilead | (10,496) | 2,021) | 2,183) | 3,052) | 1,960) | 1,315) | 1,783) | 1,253) | 1,614) | (4,170) | 1,430) | 2,180) | 1,045) | 1,010) | 1,640) | 1,789) | 1,144) | 19) | ||||||
| Product sales | 7,627) | 6,946) | 7,903) | 7,345) | 7,054) | 6,613) | 7,536) | 7,515) | 6,912) | 6,647) | 7,070) | 6,994) | 6,564) | 6,306) | 7,332) | 6,978) | 6,138) | 6,534) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| Net profit margin1 | -10.86% | 31.51% | 29.43% | 28.41% | 21.98% | 20.87% | 1.68% | 0.45% | 3.82% | 1.78% | 21.03% | 21.60% | 20.18% | 20.87% | 17.02% | 12.44% | 15.22% | 16.60% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| Net Profit Margin, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 9.80% | 5.79% | 6.91% | 4.00% | 6.45% | 7.31% | 7.59% | 9.22% | 9.71% | 11.02% | 8.95% | 11.81% | 15.50% | 13.37% | 20.39% | 23.19% | 22.04% | 22.00% | ||||||
| Amgen Inc. | 24.11% | 21.98% | 21.94% | 20.31% | 19.75% | 18.10% | 12.77% | 13.58% | 10.60% | 13.35% | 24.96% | 29.52% | 31.52% | 31.77% | 26.42% | 27.88% | 26.73% | 23.42% | ||||||
| Bristol-Myers Squibb Co. | 18.87% | 15.01% | 14.64% | 12.57% | 10.58% | 11.38% | -18.53% | -15.30% | -14.06% | -13.50% | 17.83% | 18.44% | 17.62% | 15.95% | 13.71% | 14.29% | 14.04% | 13.31% | ||||||
| Danaher Corp. | 15.95% | 14.89% | 14.71% | 14.43% | 14.21% | 15.81% | 16.33% | 16.39% | 17.83% | 18.54% | 19.94% | 22.89% | 22.80% | 23.32% | 22.91% | 21.65% | 20.61% | 21.32% | ||||||
| Eli Lilly & Co. | 33.53% | 34.99% | 31.67% | 30.99% | 25.91% | 22.66% | 23.51% | 20.48% | 18.86% | 17.08% | 15.36% | 15.55% | 22.01% | 20.54% | 21.88% | 20.63% | 19.58% | 20.90% | ||||||
| Johnson & Johnson | 21.48% | 21.83% | 28.46% | 27.26% | 25.00% | 24.41% | 15.84% | 16.74% | 43.91% | 44.92% | 41.28% | 39.58% | 14.52% | 13.77% | 18.90% | 19.95% | 19.21% | 20.90% | ||||||
| Merck & Co. Inc. | 4.77% | 13.59% | 28.08% | 29.63% | 25.79% | 27.27% | 26.68% | 19.23% | 21.98% | 3.76% | 0.61% | 7.77% | 5.34% | 22.52% | 24.49% | 25.88% | 29.00% | 26.27% | ||||||
| Pfizer Inc. | 6.80% | 11.83% | 12.42% | 15.65% | 16.84% | 12.62% | 12.62% | 7.04% | -4.62% | -0.55% | 3.56% | 15.13% | 27.38% | 31.19% | 31.27% | 29.81% | 28.94% | 27.01% | ||||||
| Regeneron Pharmaceuticals Inc. | 27.86% | 29.65% | 31.41% | 32.13% | 31.37% | 31.94% | 31.07% | 33.61% | 32.04% | 29.45% | 30.14% | 30.47% | 33.93% | 33.81% | 35.64% | 39.17% | 39.97% | 48.06% | ||||||
| Thermo Fisher Scientific Inc. | 15.04% | 15.15% | 15.05% | 15.02% | 15.23% | 15.18% | 14.77% | 14.48% | 14.69% | 14.20% | 13.99% | 13.68% | 13.14% | 13.75% | 15.47% | 15.92% | 17.37% | 18.49% | ||||||
| Vertex Pharmaceuticals Inc. | 35.00% | 35.51% | 32.94% | 31.35% | 31.86% | -8.91% | -4.86% | -4.52% | -4.74% | 39.46% | 36.68% | 35.94% | 35.40% | 35.40% | 37.20% | 37.62% | 38.26% | 30.84% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
Net profit margin = 100
× (Net income (loss) attributable to GileadQ2 2026
+ Net income (loss) attributable to GileadQ1 2026
+ Net income (loss) attributable to GileadQ4 2025
+ Net income (loss) attributable to GileadQ3 2025)
÷ (Product salesQ2 2026
+ Product salesQ1 2026
+ Product salesQ4 2025
+ Product salesQ3 2025)
= 100 × (-10,496 + 2,021 + 2,183 + 3,052)
÷ (7,627 + 6,946 + 7,903 + 7,345)
= -10.86%
2 Click competitor name to see calculations.
The financial performance exhibits significant volatility in net profitability despite a relatively stable trajectory in product sales. While revenue generally fluctuates between 6.1 billion and 7.9 billion US dollars, the net profit margin demonstrates extreme swings, indicating that bottom-line results are heavily influenced by non-operational costs or one-time financial events rather than top-line sales volume.
- Margin Stability and Growth (2022–2023)
- During the initial period from March 2022 to December 2023, the net profit margin remained relatively stable, initially fluctuating between 12.44% and 17.02% before consolidating in the 20% to 21.60% range throughout 2023. This period reflects a consistent conversion of product sales into net income.
- Significant Profitability Contractions (2024 and 2026)
- Two distinct periods of severe margin compression are observed. In the first half of 2024, the net profit margin plummeted to levels between 0.45% and 3.82%, coinciding with a substantial net loss of 4.17 billion US dollars in March 2024. A more pronounced collapse occurred in June 2026, where the net profit margin dropped to -10.86% following a net loss of 10.496 billion US dollars, despite product sales remaining strong at 7.627 billion US dollars.
- Peak Efficiency Phase (2025)
- The fiscal year 2025 represents a period of peak profitability. The net profit margin climbed steadily from 20.87% in March to a high of 31.51% by March 2026. This upward trend was driven by a significant increase in net income, reaching 3.052 billion US dollars in September 2025, while product sales grew to a peak of 7.903 billion US dollars in December 2025.
The divergence between steady product sales and erratic net profit margins suggests that the company's profitability is subject to periodic, high-impact financial adjustments or extraordinary expenses that decouple net income from operational revenue growth.
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Return on Equity (ROE)
Gilead Sciences Inc., ROE calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) attributable to Gilead | (10,496) | 2,021) | 2,183) | 3,052) | 1,960) | 1,315) | 1,783) | 1,253) | 1,614) | (4,170) | 1,430) | 2,180) | 1,045) | 1,010) | 1,640) | 1,789) | 1,144) | 19) | ||||||
| Total Gilead stockholders’ equity | 11,829) | 23,515) | 22,703) | 21,540) | 19,674) | 19,162) | 19,330) | 18,475) | 18,281) | 17,539) | 22,833) | 22,314) | 21,158) | 20,997) | 21,240) | 21,081) | 20,236) | 19,927) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| ROE1 | -27.39% | 39.19% | 37.48% | 37.65% | 32.08% | 31.13% | 2.48% | 0.69% | 5.77% | 2.77% | 24.81% | 26.33% | 25.92% | 26.59% | 21.62% | 15.82% | 20.44% | 22.66% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| ROE, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | — | — | — | — | — | 295.42% | 128.66% | 84.91% | 78.77% | 74.85% | 46.94% | 53.86% | 67.50% | 57.14% | 68.60% | 83.83% | 86.24% | 76.64% | ||||||
| Amgen Inc. | 74.80% | 84.87% | 89.06% | 72.82% | 89.11% | 95.59% | 69.59% | 56.20% | 52.83% | 74.93% | 107.78% | 98.82% | 117.67% | 148.04% | 178.97% | 187.11% | 271.85% | 624.78% | ||||||
| Bristol-Myers Squibb Co. | 41.59% | 36.25% | 38.19% | 32.55% | 28.96% | 31.16% | -54.78% | -42.34% | -38.44% | -37.28% | 27.27% | 28.57% | 24.91% | 22.97% | 20.37% | 20.44% | 20.30% | 19.79% | ||||||
| Danaher Corp. | 7.61% | 6.97% | 6.88% | 6.86% | 6.52% | 7.40% | 7.87% | 7.59% | 8.42% | 8.24% | 8.91% | 11.29% | 12.30% | 13.47% | 14.39% | 14.40% | 13.63% | 13.93% | ||||||
| Eli Lilly & Co. | 78.84% | 81.02% | 77.78% | 77.38% | 75.52% | 70.45% | 74.62% | 58.78% | 54.14% | 47.91% | 48.65% | 44.46% | 58.73% | 50.82% | 58.64% | 59.91% | 66.61% | 65.69% | ||||||
| Johnson & Johnson | 24.76% | 25.92% | 32.87% | 31.69% | 28.88% | 27.92% | 19.68% | 20.93% | 53.14% | 54.95% | 51.11% | 48.61% | 17.37% | 17.95% | 23.36% | 25.68% | 24.05% | 26.54% | ||||||
| Merck & Co. Inc. | 7.57% | 19.48% | 34.70% | 36.71% | 33.49% | 36.07% | 36.96% | 27.30% | 31.52% | 5.71% | 0.97% | 11.17% | 8.04% | 27.82% | 31.57% | 34.32% | 38.34% | 34.68% | ||||||
| Pfizer Inc. | 5.09% | 8.31% | 8.99% | 10.59% | 12.12% | 8.73% | 9.11% | 4.61% | -2.96% | -0.33% | 2.38% | 10.81% | 21.68% | 28.77% | 32.79% | 32.14% | 33.61% | 30.29% | ||||||
| Regeneron Pharmaceuticals Inc. | 13.65% | 14.08% | 14.41% | 14.79% | 14.89% | 15.31% | 15.03% | 15.87% | 15.32% | 14.29% | 15.22% | 16.03% | 17.90% | 17.80% | 19.14% | 25.05% | 27.49% | 39.84% | ||||||
| Thermo Fisher Scientific Inc. | 13.23% | 13.19% | 12.55% | 12.88% | 13.03% | 13.19% | 12.78% | 12.52% | 13.12% | 13.26% | 12.83% | 13.11% | 13.08% | 14.26% | 15.80% | 16.15% | 17.59% | 18.56% | ||||||
| Vertex Pharmaceuticals Inc. | 21.76% | 22.41% | 21.18% | 21.22% | 21.18% | -5.99% | -3.26% | -3.07% | -3.32% | 21.67% | 20.59% | 21.01% | 21.75% | 22.59% | 23.88% | 25.12% | 26.77% | 22.47% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
ROE = 100
× (Net income (loss) attributable to GileadQ2 2026
+ Net income (loss) attributable to GileadQ1 2026
+ Net income (loss) attributable to GileadQ4 2025
+ Net income (loss) attributable to GileadQ3 2025)
÷ Total Gilead stockholders’ equity
= 100 × (-10,496 + 2,021 + 2,183 + 3,052)
÷ 11,829 = -27.39%
2 Click competitor name to see calculations.
The Return on Equity (ROE) exhibits significant volatility over the analyzed period, characterized by cyclical fluctuations, a period of substantial recovery, and sharp intermittent declines. The overall trajectory reflects a highly inconsistent relationship between net income and stockholders' equity, resulting in wide swings in profitability efficiency.
- Initial Performance and Stability (2022–2023)
- Between March 2022 and December 2023, ROE remained generally robust, fluctuating between 15.82% and 26.59%. During this window, net income showed consistent growth, while stockholders' equity grew steadily from 19,927 million US$ to 22,833 million US$. This period represents a phase of stable value generation for shareholders.
- First Major Volatility Phase (Early to Mid 2024)
- A sharp deterioration in ROE is observed in the first three quarters of 2024. The ratio plummeted from 24.81% in December 2023 to a low of 0.69% by September 30, 2024. This collapse was primarily driven by a substantial net loss of 4,170 million US$ in March 2024, which significantly eroded the equity base and neutralized the profitability ratio.
- Recovery and Peak Growth (Late 2024–Early 2026)
- From December 2024 through March 2026, a strong upward trend in ROE is evident. The ratio climbed aggressively from 2.48% to a peak of 39.19%. This recovery was supported by a consistent increase in quarterly net income, reaching 3,052 million US$ in June 2025, and a gradual expansion of stockholders' equity back toward 23,515 million US$. This phase marks the highest level of capital efficiency recorded in the data set.
- Final Contraction (Mid 2026)
- A severe reversal occurred in the final reported quarter ending June 30, 2026. ROE crashed to -27.39%, the lowest point in the analyzed timeframe. This precipitous drop is attributed to a massive net loss of 10,496 million US$, which simultaneously reduced total stockholders' equity to 11,829 million US$, indicating a significant impairment of shareholder value.
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Return on Assets (ROA)
Gilead Sciences Inc., ROA calculation (quarterly data)
| Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selected Financial Data (US$ in millions) | ||||||||||||||||||||||||
| Net income (loss) attributable to Gilead | (10,496) | 2,021) | 2,183) | 3,052) | 1,960) | 1,315) | 1,783) | 1,253) | 1,614) | (4,170) | 1,430) | 2,180) | 1,045) | 1,010) | 1,640) | 1,789) | 1,144) | 19) | ||||||
| Total assets | 49,362) | 56,278) | 59,023) | 58,533) | 55,721) | 56,434) | 58,995) | 54,525) | 53,579) | 56,292) | 62,125) | 62,373) | 62,337) | 61,876) | 63,171) | 62,557) | 62,870) | 63,080) | ||||||
| Profitability Ratio | ||||||||||||||||||||||||
| ROA1 | -6.56% | 16.38% | 14.42% | 13.86% | 11.33% | 10.57% | 0.81% | 0.23% | 1.97% | 0.86% | 9.12% | 9.42% | 8.80% | 9.02% | 7.27% | 5.33% | 6.58% | 7.16% | ||||||
| Benchmarks | ||||||||||||||||||||||||
| ROA, Competitors2 | ||||||||||||||||||||||||
| AbbVie Inc. | 4.67% | 2.66% | 3.15% | 1.78% | 2.74% | 3.08% | 3.17% | 3.57% | 3.76% | 4.03% | 3.61% | 4.78% | 6.42% | 5.64% | 8.53% | 9.49% | 8.83% | 8.71% | ||||||
| Amgen Inc. | 9.14% | 8.43% | 8.51% | 7.77% | 7.53% | 6.64% | 4.45% | 4.65% | 3.44% | 4.05% | 6.91% | 8.36% | 8.84% | 8.92% | 10.06% | 10.73% | 11.09% | 9.67% | ||||||
| Bristol-Myers Squibb Co. | 10.59% | 8.41% | 7.83% | 6.23% | 5.33% | 5.86% | -9.66% | -7.75% | -6.91% | -6.21% | 8.43% | 9.08% | 8.52% | 7.75% | 6.53% | 6.80% | 6.59% | 6.07% | ||||||
| Danaher Corp. | 4.33% | 4.42% | 4.33% | 4.38% | 4.18% | 4.76% | 5.03% | 4.83% | 5.35% | 5.28% | 5.64% | 6.74% | 7.49% | 8.15% | 8.55% | 8.35% | 7.76% | 7.74% | ||||||
| Eli Lilly & Co. | 18.77% | 21.68% | 18.35% | 16.02% | 13.67% | 12.42% | 13.45% | 11.07% | 10.22% | 9.60% | 8.19% | 8.61% | 11.85% | 10.70% | 12.62% | 12.71% | 12.09% | 13.06% | ||||||
| Johnson & Johnson | 10.46% | 10.47% | 13.46% | 13.03% | 11.72% | 11.26% | 7.81% | 8.24% | 20.99% | 22.37% | 20.98% | 20.85% | 6.81% | 6.49% | 9.57% | 10.94% | 10.33% | 11.12% | ||||||
| Merck & Co. Inc. | 2.44% | 6.94% | 13.34% | 14.69% | 13.96% | 15.14% | 14.62% | 10.34% | 12.20% | 2.18% | 0.34% | 4.32% | 2.98% | 12.09% | 13.30% | 14.25% | 15.48% | 13.29% | ||||||
| Pfizer Inc. | 2.15% | 3.61% | 3.73% | 4.71% | 5.22% | 3.79% | 3.76% | 1.94% | -1.20% | -0.14% | 0.94% | 4.87% | 9.75% | 14.85% | 15.91% | 15.32% | 15.01% | 13.58% | ||||||
| Regeneron Pharmaceuticals Inc. | 10.37% | 10.82% | 11.11% | 11.40% | 11.67% | 11.98% | 11.69% | 12.43% | 11.98% | 11.22% | 11.95% | 12.41% | 14.02% | 13.91% | 14.85% | 19.40% | 20.90% | 30.11% | ||||||
| Thermo Fisher Scientific Inc. | 6.16% | 6.05% | 6.08% | 6.38% | 6.50% | 6.58% | 6.51% | 6.11% | 6.32% | 6.21% | 6.07% | 6.12% | 6.08% | 6.36% | 7.15% | 7.77% | 8.21% | 8.20% | ||||||
| Vertex Pharmaceuticals Inc. | 16.06% | 16.38% | 15.42% | 14.78% | 15.13% | -4.32% | -2.38% | -2.16% | -2.43% | 16.81% | 15.92% | 15.97% | 16.54% | 17.18% | 18.30% | 19.59% | 20.50% | 17.19% | ||||||
Based on: 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Q2 2026 Calculation
ROA = 100
× (Net income (loss) attributable to GileadQ2 2026
+ Net income (loss) attributable to GileadQ1 2026
+ Net income (loss) attributable to GileadQ4 2025
+ Net income (loss) attributable to GileadQ3 2025)
÷ Total assets
= 100 × (-10,496 + 2,021 + 2,183 + 3,052)
÷ 49,362 = -6.56%
2 Click competitor name to see calculations.
The analysis of Return on Assets (ROA) over the specified period reveals a trajectory characterized by initial stability, a period of significant volatility, a subsequent growth phase, and a final sharp contraction.
- Initial Stability and Moderate Growth
- From March 2022 through December 2023, ROA demonstrated a general upward trend, moving from 7.16% to 9.12%. This growth was supported by consistent net income levels, typically exceeding 1 billion USD, while the total asset base remained relatively stable, fluctuating slightly around 62 billion USD.
- Volatility and Recovery Phase
- A marked decline in profitability occurred in early 2024, coinciding with a net loss of 4.17 billion USD in March 2024, which suppressed the ROA to 0.86%. However, a strong recovery followed, with ROA climbing steadily throughout 2024 and 2025. This period saw ROA reach a peak of 16.38% by March 2026, driven by a combination of increasing net income and a contracting asset base.
- Asset Base Correlation
- A structural shift in the balance sheet is observed starting in March 2024, as total assets decreased from the 62 billion USD range to oscillate between approximately 53 billion and 59 billion USD. The reduction in total assets, paired with peak net income of 3.05 billion USD in September 2025, contributed to the significant expansion of the ROA during the 2025-2026 window.
- Terminal Contraction
- The period concludes with a severe downturn in June 2026. A substantial net loss of 10.496 billion USD, occurring alongside a further reduction in total assets to 49.36 billion USD, resulted in the ROA falling to -6.56%, marking the most significant negative deviation in the analyzed timeframe.
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