Common Stock Valuation Ratios (Price Multiples)
Quarterly Data
Valuation ratios measure the quantity of an asset or flaw (e.g., earnings) associated with ownership of a specified claim (e.g., a share of ownership of the enterprise).
Historical Valuation Ratios (Summary)
Vertex Pharmaceuticals Inc., historical price multiples (quarterly data)
Based on: 10-Q (reporting date: 2026-09-30), 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
The valuation multiples for Vertex Pharmaceuticals Inc. exhibit a period of cyclical volatility characterized by a general expansion in earnings-based multiples toward the end of the analyzed timeframe. There is a strong positive correlation between price-to-earnings and price-to-operating profit metrics, suggesting that valuation fluctuations are primarily driven by equity pricing and net profitability trends rather than significant shifts in operating efficiency.
- Earnings and Operating Profit Multiples
- The Price to earnings (P/E) ratio fluctuated between 23.02 and 30.42 during the 2022-2023 period before reaching a peak of 33.85 by September 30, 2026. Similarly, the Price to operating profit (P/OP) ratio followed a nearly identical trajectory, moving from a low of 17.75 in December 2022 to a peak of 31.27 in September 2026. This parallel movement indicates a consistent relationship between the company's market valuation and its bottom-line performance.
- Revenue Valuation Trends
- The Price to sales (P/S) ratio showed a steady climb from 8.17 in March 2022 to a high of 12.35 in June 2024. Following this peak, a contraction occurred, with the ratio dipping to 8.42 by June 2025. However, a recovery trend is evident in the subsequent quarters, with the ratio returning to 10.39 by September 2026, indicating a renewed market premium on the company's revenue streams.
- Book Value Analysis
- The Price to book value (P/BV) ratio remained relatively stable between 5.50 and 6.26 throughout 2022 and 2023. A significant deviation occurred in mid-2024, where the ratio spiked to 8.64 in June 2024, representing the highest valuation relative to equity in the sequence. The ratio subsequently normalized, oscillating between 5.56 and 7.01 through 2025 and 2026.
Overall, the data indicates a trend of expanding valuation multiples in the latter half of the period, particularly regarding earnings and operating profits. The spikes observed in the P/S and P/BV ratios during 2024 suggest a temporary period of aggressive valuation or a decrease in the underlying book value, both of which corrected by 2025.
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Price to Earnings (P/E)
Vertex Pharmaceuticals Inc., historical P/E calculation (quarterly data)
| Sep 30, 2026 | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. shares of common stock outstanding1 | 253,537,674 | 253,460,924 | 253,805,417 | 254,034,190 | 253,718,831 | 256,390,651 | 256,797,187 | 256,789,869 | 257,529,290 | 258,102,203 | 258,053,387 | 258,307,816 | 257,683,184 | 258,094,815 | 257,551,600 | 257,091,441 | 256,691,452 | 256,459,482 | 255,755,961 | ||||||
| Selected Financial Data (US$) | |||||||||||||||||||||||||
| Net income (loss) (in thousands) | 653,600) | 1,099,800) | 1,031,400) | 1,191,100) | 1,082,900) | 1,032,900) | 646,300) | 913,000) | 1,045,400) | (3,593,600) | 1,099,600) | 968,800) | 1,035,300) | 915,700) | 699,800) | 818,900) | 930,500) | 810,500) | 762,100) | ||||||
| Earnings per share (EPS)2 | 15.68 | 17.38 | 17.09 | 15.56 | 14.48 | 14.19 | -3.85 | -2.09 | -1.86 | -1.90 | 15.58 | 14.01 | 13.46 | 13.04 | 12.66 | 12.92 | 12.75 | 12.46 | 9.58 | ||||||
| Share price1, 3 | 530.76 | 478.71 | 424.36 | 491.47 | 421.67 | 374.98 | 450.03 | 462.58 | 499.88 | 494.46 | 410.24 | 426.29 | 378.25 | 358.40 | 346.03 | 297.40 | 313.89 | 288.03 | 253.93 | ||||||
| Valuation Ratio | |||||||||||||||||||||||||
| P/E ratio4 | 33.85 | 27.54 | 24.83 | 31.58 | 29.11 | 26.43 | — | — | — | — | 26.34 | 30.42 | 28.09 | 27.49 | 27.34 | 23.02 | 24.62 | 23.12 | 26.50 | ||||||
| Benchmarks | |||||||||||||||||||||||||
| P/E Ratio, Competitors5 | |||||||||||||||||||||||||
| AbbVie Inc. | 48.88 | 68.64 | 97.96 | 94.06 | 159.78 | 92.57 | 77.73 | 79.59 | 69.16 | 62.04 | 48.26 | 63.84 | 38.27 | 30.55 | 34.43 | 22.62 | 19.16 | 19.44 | 21.64 | ||||||
| Amgen Inc. | — | 25.22 | 22.82 | 25.81 | 24.59 | 23.15 | 25.49 | 38.24 | 40.68 | 53.65 | 44.38 | 23.14 | 18.09 | 16.31 | 16.18 | 19.56 | 21.00 | 20.03 | 22.23 | ||||||
| Bristol-Myers Squibb Co. | 13.58 | 14.27 | 17.01 | 17.30 | 15.38 | 17.46 | 18.29 | — | — | — | — | 12.27 | 13.01 | 15.93 | 19.43 | 23.97 | 23.71 | 24.14 | 25.64 | ||||||
| Danaher Corp. | 37.99 | 31.43 | 37.32 | 40.93 | 44.52 | 39.84 | 36.51 | 38.12 | 48.49 | 45.39 | 42.59 | 39.09 | 24.76 | 29.99 | 25.00 | 25.65 | 26.65 | 32.73 | 32.15 | ||||||
| Eli Lilly & Co. | 46.86 | 41.23 | 34.82 | 47.45 | 43.36 | 43.95 | 67.76 | 77.63 | 96.05 | 109.42 | 120.94 | 135.24 | 110.43 | 76.21 | 65.16 | 50.08 | 55.53 | 51.05 | 45.29 | ||||||
| Gilead Sciences Inc. | — | — | 18.06 | 21.54 | 18.18 | 21.68 | 20.62 | 296.57 | 925.87 | 89.29 | 166.76 | 16.17 | 17.10 | 17.88 | 17.75 | 22.68 | 29.30 | 18.66 | 17.25 | ||||||
| Johnson & Johnson | 38.56 | 29.70 | 25.87 | 21.66 | 18.51 | 18.02 | 17.14 | 26.92 | 27.19 | 10.11 | 9.46 | 10.73 | 10.12 | 33.35 | 33.43 | 22.97 | 23.52 | 24.98 | 23.95 | ||||||
| Merck & Co. Inc. | — | 99.98 | 31.27 | 16.79 | 11.00 | 12.30 | 11.98 | 13.49 | 20.98 | 20.73 | 140.05 | 893.99 | 56.85 | 86.53 | 22.92 | 19.21 | 16.41 | 13.36 | 15.70 | ||||||
| Pfizer Inc. | 42.39 | 33.42 | 20.12 | 19.83 | 14.06 | 13.09 | 17.22 | 18.42 | 37.00 | — | — | 73.42 | 16.60 | 9.42 | 7.44 | 7.58 | 8.81 | 9.56 | 11.11 | ||||||
| Regeneron Pharmaceuticals Inc. | 19.93 | 17.56 | 16.27 | 18.19 | 15.03 | 13.29 | 13.65 | 17.76 | 19.79 | 27.88 | 26.78 | 25.99 | 22.35 | 19.48 | 19.77 | 19.68 | 14.98 | 11.67 | 9.15 | ||||||
| Thermo Fisher Scientific Inc. | 36.52 | 30.48 | 25.46 | 28.82 | 32.45 | 26.56 | 24.55 | 32.03 | 34.78 | 37.81 | 36.21 | 35.65 | 29.57 | 37.01 | 34.99 | 30.55 | 27.64 | 31.09 | 28.15 | ||||||
Based on: 10-Q (reporting date: 2026-09-30), 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Data adjusted for splits and stock dividends.
2 Q3 2026 Calculation
EPS
= (Net income (loss)Q3 2026
+ Net income (loss)Q2 2026
+ Net income (loss)Q1 2026
+ Net income (loss)Q4 2025)
÷ No. shares of common stock outstanding
= (653,600,000 + 1,099,800,000 + 1,031,400,000 + 1,191,100,000)
÷ 253,537,674 = 15.68
3 Closing price as at the filing date of Vertex Pharmaceuticals Inc. Quarterly or Annual Report.
4 Q3 2026 Calculation
P/E ratio = Share price ÷ EPS
= 530.76 ÷ 15.68 = 33.85
5 Click competitor name to see calculations.
The financial trajectory from March 2022 through September 2026 is characterized by a strong appreciation in share price and significant volatility in earnings per share (EPS), which directly impacted the price-to-earnings (P/E) valuation ratios.
- Share Price Trend
- A consistent long-term upward trend is observed in the share price, which rose from US$ 253.93 in March 2022 to a peak of US$ 530.76 by September 2026. Despite intermittent fluctuations, the overall movement indicates a substantial increase in market valuation over the period.
- Earnings Per Share (EPS) Dynamics
- EPS demonstrated steady growth during the first two years, rising from US$ 9.58 in March 2022 to US$ 15.58 in March 2024. This growth was followed by a period of significant instability between June 2024 and March 2025, where earnings became negative, reaching a trough of -US$ 3.85. A recovery began in June 2025, with EPS returning to positive territory and eventually reaching US$ 15.68 by September 2026.
- P/E Ratio Interpretation
- The P/E ratio remained relatively stable, fluctuating between 23.02 and 30.42 from March 2022 to March 2024. Due to the shift to negative earnings, the ratio was not applicable between June 2024 and March 2025. Following the return to profitability in June 2025, the P/E ratio resumed at 26.43 and trended upward to reach its highest point of 33.85 in September 2026. This expansion in the P/E ratio suggests an increase in market confidence or higher growth expectations relative to the current earnings.
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Price to Operating Profit (P/OP)
Vertex Pharmaceuticals Inc., historical P/OP calculation (quarterly data)
| Sep 30, 2026 | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. shares of common stock outstanding1 | 253,537,674 | 253,460,924 | 253,805,417 | 254,034,190 | 253,718,831 | 256,390,651 | 256,797,187 | 256,789,869 | 257,529,290 | 258,102,203 | 258,053,387 | 258,307,816 | 257,683,184 | 258,094,815 | 257,551,600 | 257,091,441 | 256,691,452 | 256,459,482 | 255,755,961 | ||||||
| Selected Financial Data (US$) | |||||||||||||||||||||||||
| Income (loss) from operations (in thousands) | 712,900) | 1,246,900) | 1,138,100) | 1,205,900) | 1,186,200) | 1,151,100) | 630,100) | 1,026,000) | 1,116,300) | (3,514,700) | 1,139,500) | 988,500) | 1,038,100) | 1,026,400) | 779,000) | 1,033,500) | 1,126,700) | 1,106,300) | 1,040,900) | ||||||
| Operating profit per share2 | 16.97 | 18.85 | 18.44 | 16.43 | 15.74 | 15.30 | -2.89 | -0.91 | -1.05 | -1.35 | 16.25 | 14.84 | 15.05 | 15.36 | 15.71 | 16.75 | 16.17 | 15.91 | 11.48 | ||||||
| Share price1, 3 | 530.76 | 478.71 | 424.36 | 491.47 | 421.67 | 374.98 | 450.03 | 462.58 | 499.88 | 494.46 | 410.24 | 426.29 | 378.25 | 358.40 | 346.03 | 297.40 | 313.89 | 288.03 | 253.93 | ||||||
| Valuation Ratio | |||||||||||||||||||||||||
| P/OP ratio4 | 31.27 | 25.40 | 23.01 | 29.92 | 26.79 | 24.50 | — | — | — | — | 25.25 | 28.74 | 25.14 | 23.33 | 22.03 | 17.75 | 19.41 | 18.11 | 22.13 | ||||||
| Benchmarks | |||||||||||||||||||||||||
| P/OP Ratio, Competitors5 | |||||||||||||||||||||||||
| AbbVie Inc. | 23.81 | 25.67 | 23.23 | 26.37 | 42.20 | 31.76 | 32.37 | 37.26 | 25.63 | 26.99 | 22.62 | 24.34 | 16.55 | 15.26 | 16.15 | 14.78 | 14.52 | 14.12 | 14.57 | ||||||
| Amgen Inc. | — | 19.30 | 16.84 | 21.92 | 19.86 | 18.71 | 20.31 | 21.55 | 27.68 | 27.12 | 23.97 | 19.69 | 15.45 | 13.71 | 14.25 | 13.40 | 14.89 | 14.08 | 15.88 | ||||||
| Bristol-Myers Squibb Co. | 10.86 | 11.30 | 12.42 | 12.20 | 10.25 | 11.07 | 13.65 | — | — | — | — | 13.53 | 14.14 | 16.24 | 17.09 | 18.29 | 17.79 | 18.62 | 20.32 | ||||||
| Danaher Corp. | 31.53 | 24.54 | 28.93 | 31.54 | 33.80 | 30.79 | 28.49 | 30.56 | 39.52 | 38.14 | 37.52 | 35.64 | 23.61 | 27.01 | 21.31 | 20.97 | 20.71 | 25.91 | 26.48 | ||||||
| Eli Lilly & Co. | 37.05 | 32.74 | 27.92 | 37.24 | 34.60 | 35.19 | 53.43 | 63.73 | 79.30 | 88.66 | 99.34 | 109.75 | 93.27 | 69.42 | 59.60 | 43.88 | 46.48 | 39.20 | 36.49 | ||||||
| Gilead Sciences Inc. | — | — | 16.05 | 18.29 | 14.06 | 17.00 | 14.96 | 85.65 | 143.05 | 36.80 | 51.26 | 12.05 | 12.16 | 11.57 | 11.21 | 14.21 | 16.27 | 11.02 | 10.78 | ||||||
| Johnson & Johnson | 25.09 | 24.10 | 21.40 | 22.95 | 19.83 | 19.04 | 17.74 | 18.20 | 18.65 | 17.54 | 16.96 | 17.78 | 15.69 | 18.91 | 18.26 | 17.62 | 19.64 | 20.45 | 21.06 | ||||||
| Merck & Co. Inc. | — | 49.74 | 23.37 | 14.44 | 9.67 | 10.57 | 10.37 | 11.60 | 18.67 | 18.41 | 75.94 | 138.56 | 33.75 | 44.67 | 18.53 | 15.55 | 13.85 | 11.72 | 14.29 | ||||||
| Pfizer Inc. | 12.54 | 10.48 | 10.37 | 10.82 | 10.07 | 9.49 | 11.27 | 11.92 | 27.24 | — | — | 121.63 | 17.49 | 9.17 | 6.74 | 6.80 | 7.82 | 9.11 | 11.49 | ||||||
| Regeneron Pharmaceuticals Inc. | 19.73 | 19.78 | 19.83 | 22.90 | 18.65 | 15.42 | 16.03 | 19.63 | 23.18 | 30.86 | 26.82 | 25.39 | 21.13 | 19.32 | 18.68 | 18.01 | 12.91 | 9.68 | 7.98 | ||||||
| Thermo Fisher Scientific Inc. | 30.50 | 26.07 | 22.09 | 24.94 | 28.40 | 23.62 | 21.64 | 27.65 | 29.74 | 32.66 | 31.40 | 31.16 | 25.59 | 31.55 | 29.54 | 25.30 | 21.43 | 23.99 | 21.84 | ||||||
Based on: 10-Q (reporting date: 2026-09-30), 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Data adjusted for splits and stock dividends.
2 Q3 2026 Calculation
Operating profit per share
= (Income (loss) from operationsQ3 2026
+ Income (loss) from operationsQ2 2026
+ Income (loss) from operationsQ1 2026
+ Income (loss) from operationsQ4 2025)
÷ No. shares of common stock outstanding
= (712,900,000 + 1,246,900,000 + 1,138,100,000 + 1,205,900,000)
÷ 253,537,674 = 16.97
3 Closing price as at the filing date of Vertex Pharmaceuticals Inc. Quarterly or Annual Report.
4 Q3 2026 Calculation
P/OP ratio = Share price ÷ Operating profit per share
= 530.76 ÷ 16.97 = 31.27
5 Click competitor name to see calculations.
The Price to Operating Profit (P/OP) ratio exhibits a general upward trajectory over the analyzed period, characterized by significant fluctuations and a period of calculation unavailability due to temporary negative operating margins.
- Initial Valuation Stability (2022)
- From March 2022 to December 2022, the P/OP ratio remained relatively range-bound, fluctuating between a high of 22.13 and a low of 17.75. This period suggests a stable market valuation relative to the growth in operating profit per share.
- Valuation Expansion (2023)
- A consistent upward trend is observed throughout 2023, with the P/OP ratio climbing from 22.03 in March to 28.74 by December. This expansion indicates that the share price increased at a pace that significantly exceeded the growth of operational profits during this timeframe.
- Operational Anomaly (2024–2025)
- Between June 2024 and March 2025, operating profit per share entered negative territory, reaching a trough of -2.89 US$ in March 2025. Because of these negative values, the P/OP ratio was not calculable during this interval, marking a period of operational contraction despite the share price remaining elevated.
- Post-Recovery Trend (2025–2026)
- Following the return to profitability in June 2025, the P/OP ratio resumed an increasing trend. While a brief correction to 23.01 occurred in March 2026, the ratio ultimately reached its peak of 31.27 in September 2026. This suggests that market participants applied a higher valuation multiple to the company's operating profits toward the end of the analyzed period compared to the start.
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Price to Sales (P/S)
Vertex Pharmaceuticals Inc., historical P/S calculation (quarterly data)
| Sep 30, 2026 | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. shares of common stock outstanding1 | 253,537,674 | 253,460,924 | 253,805,417 | 254,034,190 | 253,718,831 | 256,390,651 | 256,797,187 | 256,789,869 | 257,529,290 | 258,102,203 | 258,053,387 | 258,307,816 | 257,683,184 | 258,094,815 | 257,551,600 | 257,091,441 | 256,691,452 | 256,459,482 | 255,755,961 | ||||||
| Selected Financial Data (US$) | |||||||||||||||||||||||||
| Revenues (in thousands) | 3,440,800) | 3,333,900) | 2,986,900) | 3,190,000) | 3,076,400) | 2,964,700) | 2,770,200) | 2,912,000) | 2,771,900) | 2,645,600) | 2,690,600) | 2,517,700) | 2,483,500) | 2,493,200) | 2,374,800) | 2,302,700) | 2,334,300) | 2,196,200) | 2,097,500) | ||||||
| Sales per share2 | 51.08 | 49.66 | 48.14 | 47.24 | 46.21 | 44.54 | 43.22 | 42.91 | 41.26 | 40.05 | 39.47 | 38.21 | 37.47 | 36.83 | 35.75 | 34.74 | 33.90 | 32.56 | 31.07 | ||||||
| Share price1, 3 | 530.76 | 478.71 | 424.36 | 491.47 | 421.67 | 374.98 | 450.03 | 462.58 | 499.88 | 494.46 | 410.24 | 426.29 | 378.25 | 358.40 | 346.03 | 297.40 | 313.89 | 288.03 | 253.93 | ||||||
| Valuation Ratio | |||||||||||||||||||||||||
| P/S ratio4 | 10.39 | 9.64 | 8.82 | 10.40 | 9.13 | 8.42 | 10.41 | 10.78 | 12.12 | 12.35 | 10.39 | 11.16 | 10.10 | 9.73 | 9.68 | 8.56 | 9.26 | 8.85 | 8.17 | ||||||
| Benchmarks | |||||||||||||||||||||||||
| P/S Ratio, Competitors5 | |||||||||||||||||||||||||
| AbbVie Inc. | 7.66 | 6.73 | 5.67 | 6.50 | 6.40 | 5.97 | 5.68 | 6.04 | 6.38 | 6.02 | 5.32 | 5.72 | 4.52 | 4.74 | 4.60 | 4.61 | 4.44 | 4.28 | 4.76 | ||||||
| Amgen Inc. | — | 6.08 | 5.02 | 5.66 | 4.99 | 4.57 | 4.61 | 4.88 | 5.53 | 5.68 | 5.93 | 5.78 | 5.34 | 5.14 | 5.14 | 5.17 | 5.85 | 5.35 | 5.21 | ||||||
| Bristol-Myers Squibb Co. | 2.51 | 2.69 | 2.55 | 2.53 | 1.93 | 1.85 | 2.08 | 2.36 | 2.38 | 2.20 | 1.99 | 2.19 | 2.40 | 2.81 | 3.10 | 3.29 | 3.39 | 3.39 | 3.41 | ||||||
| Danaher Corp. | 6.42 | 5.01 | 5.56 | 6.02 | 6.43 | 5.66 | 5.77 | 6.23 | 7.95 | 8.10 | 7.90 | 7.76 | 5.63 | 6.77 | 5.76 | 5.79 | 5.66 | 6.59 | 6.68 | ||||||
| Eli Lilly & Co. | 14.95 | 13.82 | 12.18 | 15.03 | 13.44 | 11.39 | 15.36 | 18.25 | 19.67 | 20.64 | 20.66 | 20.77 | 17.18 | 16.78 | 13.38 | 10.96 | 11.46 | 9.99 | 9.47 | ||||||
| Gilead Sciences Inc. | 6.88 | 5.44 | 5.69 | 6.34 | 5.16 | 4.76 | 4.31 | 4.98 | 4.18 | 3.41 | 2.97 | 3.40 | 3.69 | 3.61 | 3.70 | 3.86 | 3.64 | 2.84 | 2.86 | ||||||
| Johnson & Johnson | 6.25 | 6.38 | 5.65 | 6.16 | 5.04 | 4.51 | 4.19 | 4.26 | 4.55 | 4.44 | 4.25 | 4.43 | 4.01 | 4.84 | 4.60 | 4.34 | 4.69 | 4.80 | 5.00 | ||||||
| Merck & Co. Inc. | — | 4.77 | 4.25 | 4.71 | 3.26 | 3.17 | 3.27 | 3.60 | 4.03 | 4.56 | 5.26 | 5.43 | 4.42 | 4.62 | 5.16 | 4.71 | 4.25 | 3.87 | 4.12 | ||||||
| Pfizer Inc. | 2.69 | 2.27 | 2.38 | 2.46 | 2.20 | 2.20 | 2.17 | 2.32 | 2.60 | 3.00 | 2.86 | 2.61 | 2.51 | 2.58 | 2.32 | 2.37 | 2.63 | 2.77 | 3.00 | ||||||
| Regeneron Pharmaceuticals Inc. | 5.68 | 4.89 | 4.82 | 5.71 | 4.83 | 4.17 | 4.36 | 5.52 | 6.65 | 8.93 | 7.89 | 7.84 | 6.81 | 6.61 | 6.69 | 7.01 | 5.87 | 4.66 | 4.40 | ||||||
| Thermo Fisher Scientific Inc. | 5.45 | 4.58 | 3.86 | 4.34 | 4.87 | 4.05 | 3.73 | 4.73 | 5.04 | 5.55 | 5.14 | 4.99 | 4.05 | 4.87 | 4.81 | 4.73 | 4.40 | 5.40 | 5.20 | ||||||
Based on: 10-Q (reporting date: 2026-09-30), 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Data adjusted for splits and stock dividends.
2 Q3 2026 Calculation
Sales per share
= (RevenuesQ3 2026
+ RevenuesQ2 2026
+ RevenuesQ1 2026
+ RevenuesQ4 2025)
÷ No. shares of common stock outstanding
= (3,440,800,000 + 3,333,900,000 + 2,986,900,000 + 3,190,000,000)
÷ 253,537,674 = 51.08
3 Closing price as at the filing date of Vertex Pharmaceuticals Inc. Quarterly or Annual Report.
4 Q3 2026 Calculation
P/S ratio = Share price ÷ Sales per share
= 530.76 ÷ 51.08 = 10.39
5 Click competitor name to see calculations.
The valuation of the common stock over the observed period reflects a pattern of volatility in market sentiment contrasted against a backdrop of consistent fundamental growth in revenue per share.
- Sales per Share Growth
- A consistent and linear upward trend is observed in sales per share, which increased from 31.07 US$ in March 2022 to 51.08 US$ by September 2026. This steady growth indicates a reliable expansion in the company's revenue-generating capacity on a per-share basis throughout the entire duration of the analysis.
- Share Price Volatility
- The share price experienced significant fluctuations, rising from an initial 253.93 US$ in March 2022 to a closing value of 530.76 US$ in September 2026. While the long-term trajectory is positive, the price exhibited notable instability, specifically peaking at 499.88 US$ in June 2024 before undergoing a correction to 374.98 US$ by June 2025.
- Price-to-Sales (P/S) Ratio Analysis
- The P/S ratio fluctuated between a low of 8.17 in March 2022 and a high of 12.35 in June 2024. The expansion of this ratio up to mid-2024 suggests a period where the market assigned a higher premium to each dollar of sales. This was followed by a contraction phase where the ratio declined to 8.42 in June 2025, signaling a temporary reduction in valuation multiples. By September 2026, the ratio recovered to 10.39, indicating a return to higher valuation levels despite the intermittent dip.
Overall, the data indicates that while the fundamental sales growth remained stable and predictable, the P/S ratio was driven primarily by the volatility of the share price, reflecting shifting market expectations over the five-year period.
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Price to Book Value (P/BV)
Vertex Pharmaceuticals Inc., historical P/BV calculation (quarterly data)
| Sep 30, 2026 | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 | Jun 30, 2023 | Mar 31, 2023 | Dec 31, 2022 | Sep 30, 2022 | Jun 30, 2022 | Mar 31, 2022 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. shares of common stock outstanding1 | 253,537,674 | 253,460,924 | 253,805,417 | 254,034,190 | 253,718,831 | 256,390,651 | 256,797,187 | 256,789,869 | 257,529,290 | 258,102,203 | 258,053,387 | 258,307,816 | 257,683,184 | 258,094,815 | 257,551,600 | 257,091,441 | 256,691,452 | 256,459,482 | 255,755,961 | ||||||
| Selected Financial Data (US$) | |||||||||||||||||||||||||
| Shareholders’ equity (in thousands) | 20,907,400) | 20,247,900) | 19,361,900) | 18,665,800) | 17,318,800) | 17,175,400) | 16,496,300) | 16,409,600) | 15,630,900) | 14,774,700) | 18,546,600) | 17,580,400) | 16,512,800) | 15,470,200) | 14,432,300) | 13,912,700) | 13,029,600) | 11,933,500) | 10,907,000) | ||||||
| Book value per share (BVPS)2 | 82.46 | 79.89 | 76.29 | 73.48 | 68.26 | 66.99 | 64.24 | 63.90 | 60.70 | 57.24 | 71.87 | 68.06 | 64.08 | 59.94 | 56.04 | 54.12 | 50.76 | 46.53 | 42.65 | ||||||
| Share price1, 3 | 530.76 | 478.71 | 424.36 | 491.47 | 421.67 | 374.98 | 450.03 | 462.58 | 499.88 | 494.46 | 410.24 | 426.29 | 378.25 | 358.40 | 346.03 | 297.40 | 313.89 | 288.03 | 253.93 | ||||||
| Valuation Ratio | |||||||||||||||||||||||||
| P/BV ratio4 | 6.44 | 5.99 | 5.56 | 6.69 | 6.18 | 5.60 | 7.01 | 7.24 | 8.24 | 8.64 | 5.71 | 6.26 | 5.90 | 5.98 | 6.18 | 5.50 | 6.18 | 6.19 | 5.95 | ||||||
| Benchmarks | |||||||||||||||||||||||||
| P/BV Ratio, Competitors5 | |||||||||||||||||||||||||
| AbbVie Inc. | — | — | — | — | — | — | 229.63 | 102.40 | 58.73 | 48.87 | 36.12 | 29.97 | 20.61 | 20.62 | 19.68 | 15.52 | 16.06 | 16.76 | 16.59 | ||||||
| Amgen Inc. | — | 18.86 | 19.37 | 22.99 | 17.91 | 20.63 | 24.36 | 26.61 | 22.86 | 28.34 | 33.25 | 24.94 | 17.87 | 19.19 | 23.95 | 35.01 | 39.30 | 54.46 | 138.87 | ||||||
| Bristol-Myers Squibb Co. | 5.36 | 5.94 | 6.17 | 6.61 | 5.01 | 5.06 | 5.70 | 6.98 | 6.60 | 6.01 | 5.49 | 3.35 | 3.72 | 3.97 | 4.46 | 4.88 | 4.85 | 4.90 | 5.07 | ||||||
| Danaher Corp. | 3.07 | 2.39 | 2.60 | 2.82 | 3.05 | 2.60 | 2.70 | 3.00 | 3.68 | 3.82 | 3.51 | 3.47 | 2.78 | 3.65 | 3.33 | 3.64 | 3.77 | 4.36 | 4.36 | ||||||
| Eli Lilly & Co. | 32.09 | 32.51 | 28.21 | 36.91 | 33.55 | 33.19 | 47.74 | 57.93 | 56.45 | 59.24 | 57.94 | 65.80 | 49.10 | 44.75 | 33.11 | 29.36 | 33.27 | 34.00 | 29.75 | ||||||
| Gilead Sciences Inc. | 16.23 | 13.72 | 7.08 | 8.07 | 6.85 | 6.96 | 6.42 | 7.36 | 6.36 | 5.15 | 4.61 | 4.01 | 4.50 | 4.63 | 4.72 | 4.90 | 4.63 | 3.82 | 3.91 | ||||||
| Johnson & Johnson | 7.61 | 7.35 | 6.70 | 7.12 | 5.86 | 5.20 | 4.79 | 5.30 | 5.69 | 5.37 | 5.20 | 5.48 | 4.92 | 5.79 | 6.00 | 5.37 | 6.04 | 6.01 | 6.36 | ||||||
| Merck & Co. Inc. | — | 7.57 | 6.09 | 5.82 | 4.04 | 4.12 | 4.32 | 4.99 | 5.73 | 6.53 | 8.00 | 8.68 | 6.35 | 6.96 | 6.38 | 6.07 | 5.63 | 5.12 | 5.44 | ||||||
| Pfizer Inc. | 1.92 | 1.70 | 1.67 | 1.78 | 1.49 | 1.59 | 1.50 | 1.68 | 1.70 | 1.92 | 1.74 | 1.75 | 1.80 | 2.04 | 2.14 | 2.48 | 2.83 | 3.21 | 3.37 | ||||||
| Regeneron Pharmaceuticals Inc. | 2.87 | 2.40 | 2.29 | 2.62 | 2.22 | 1.98 | 2.09 | 2.67 | 3.14 | 4.27 | 3.83 | 3.96 | 3.58 | 3.49 | 3.52 | 3.77 | 3.75 | 3.21 | 3.65 | ||||||
| Thermo Fisher Scientific Inc. | 4.72 | 4.03 | 3.36 | 3.62 | 4.18 | 3.46 | 3.24 | 4.09 | 4.36 | 4.96 | 4.80 | 4.57 | 3.88 | 4.84 | 4.99 | 4.83 | 4.46 | 5.47 | 5.23 | ||||||
Based on: 10-Q (reporting date: 2026-09-30), 10-Q (reporting date: 2026-06-30), 10-Q (reporting date: 2026-03-31), 10-K (reporting date: 2025-12-31), 10-Q (reporting date: 2025-09-30), 10-Q (reporting date: 2025-06-30), 10-Q (reporting date: 2025-03-31), 10-K (reporting date: 2024-12-31), 10-Q (reporting date: 2024-09-30), 10-Q (reporting date: 2024-06-30), 10-Q (reporting date: 2024-03-31), 10-K (reporting date: 2023-12-31), 10-Q (reporting date: 2023-09-30), 10-Q (reporting date: 2023-06-30), 10-Q (reporting date: 2023-03-31), 10-K (reporting date: 2022-12-31), 10-Q (reporting date: 2022-09-30), 10-Q (reporting date: 2022-06-30), 10-Q (reporting date: 2022-03-31).
1 Data adjusted for splits and stock dividends.
2 Q3 2026 Calculation
BVPS = Shareholders’ equity ÷ No. shares of common stock outstanding
= 20,907,400,000 ÷ 253,537,674 = 82.46
3 Closing price as at the filing date of Vertex Pharmaceuticals Inc. Quarterly or Annual Report.
4 Q3 2026 Calculation
P/BV ratio = Share price ÷ BVPS
= 530.76 ÷ 82.46 = 6.44
5 Click competitor name to see calculations.
The analysis of the valuation metrics reveals a period of relative stability followed by a significant volatility spike in mid-2024. While the share price and book value per share generally trended upward over the observed period, the Price to Book Value (P/BV) ratio experienced a notable divergence during the second quarter of 2024.
- Book Value per Share (BVPS) Progression
- BVPS demonstrated a consistent long-term growth trajectory, increasing from 42.65 USD in March 2022 to 82.46 USD by September 2026. A significant anomaly is observed in June 2024, where BVPS dropped sharply to 57.24 USD from 71.87 USD in the previous quarter. Following this contraction, the BVPS resumed a steady upward trend through the remainder of the period.
- Share Price Dynamics
- The share price exhibited a strong overall upward trend, rising from 253.93 USD in March 2022 to 530.76 USD by September 2026. This growth was characterized by periods of acceleration, particularly between December 2023 and June 2024, interspersed with periodic corrections, such as the decline observed in the first half of 2025.
- P/BV Ratio Analysis
- Between March 2022 and March 2024, the P/BV ratio remained relatively stable, oscillating between 5.50 and 6.26. A sharp peak occurred in June 2024, with the ratio reaching 8.64, primarily driven by the convergence of a rising share price and a sudden decrease in BVPS. Subsequent to this peak, the ratio underwent a correction phase, declining to 5.60 by June 2025 before stabilizing in the 5.56 to 6.44 range through September 2026.
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