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Cytokinetics Inc. (NASDAQ:CYTK)

This company has been moved to the archive! The financial data has not been updated since November 3, 2023.

Analysis of Income Taxes

Microsoft Excel

Income Tax Expense (Benefit)

Cytokinetics Inc., income tax expense (benefit), continuing operations

US$ in thousands

Microsoft Excel
12 months ended: Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
Current income tax provision — — — — —
Deferred income tax provision — — — — —
Income tax provision — — — — —

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).


An analysis of the income tax provisions from 2018 to 2022 reveals a total absence of reported numeric data for all specified categories. Consequently, no trends or patterns can be identified regarding the company's tax obligations or benefits during this period.

Current Income Tax Provision
No values were recorded for the period spanning December 31, 2018, to December 31, 2022, precluding an assessment of current tax liabilities.
Deferred Income Tax Provision
The lack of reported figures for deferred income tax provisions prevents the evaluation of temporary differences and their impact on future tax positions.
Total Income Tax Provision
Due to the absence of both current and deferred tax data, it is not possible to determine the aggregate income tax expense or benefit for the analyzed timeframe.

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Effective Income Tax Rate (EITR)

Cytokinetics Inc., effective income tax rate (EITR) reconciliation

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
Tax at federal statutory tax rate 21.00% 21.00% 21.00% 21.00% 21.00%
State tax, net of federal benefits 1.00% 0.00% 1.00% 3.00% 0.00%
Change in state effected rates 0.00% -1.00% -2.00% 4.00% -4.00%
Tax credits, net 4.00% 3.00% 3.00% 3.00% 1.00%
Change in valuation allowance -26.00% -24.00% -23.00% -30.00% -17.00%
Stock-based compensation 2.00% 2.00% 1.00% -1.00% -1.00%
Other -2.00% -1.00% -1.00% 0.00% 0.00%
Effective tax rate 0.00% 0.00% 0.00% 0.00% 0.00%

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).


The reconciliation of the effective income tax rate is characterized by a stable federal statutory baseline offset by significant volatility stemming from valuation allowance adjustments. The overall tax profile is primarily driven by non-cash accounting adjustments rather than fluctuations in statutory rates or operational tax liabilities.

Federal Statutory Rate Stability
The federal statutory tax rate remained constant at 21.00% for all reporting periods between 2018 and 2022, serving as the consistent anchor for the tax calculation.
Impact of Valuation Allowances
Changes in valuation allowances constitute the most substantial variance in the tax reconciliation. These figures were consistently negative and material throughout the five-year period, reaching a peak of -30.00% in 2019 and stabilizing between -23.00% and -26.00% from 2020 through 2022. This represents the primary driver of the deviation from the statutory rate.
Trend in Tax Credits
A consistent upward trend is observed in net tax credits, which grew from 1.00% in 2018 to 4.00% in 2022. This indicates a progressive increase in the utilization of credits to reduce the taxable impact.
Secondary Tax Adjustments
State-level tax impacts remained marginal and inconsistent, with state taxes fluctuating between 1.00% and 3.00% and state effected rates showing erratic movements between -4.00% and 4.00%. Stock-based compensation adjustments transitioned from a negative 1.00% in 2018 and 2019 to a positive 2.00% by 2022, while "Other" adjustments introduced a slight negative pressure starting in 2020.

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Components of Deferred Tax Assets and Liabilities

Cytokinetics Inc., components of deferred tax assets and liabilities

US$ in thousands

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
Net operating loss carryforwards 202,459 181,977 162,514 143,228 121,748
Tax credits 98,292 77,366 71,976 67,892 64,797
Liability related to sale of future royalties 68,366 38,302 36,989 35,213 26,294
Reserves and accruals 23,950 15,409 10,876 8,690 5,772
Capitalized R&D 48,047 1,115 2,370 3,949 4,614
Long-term lease liability 28,901 26,223 718 1,674 —
Deferred revenue — 18,608 — — —
Depreciation and amortization — — 746 722 586
Other — — — 58 —
Noncurrent deferred tax assets 470,015 359,000 286,189 261,426 223,811
Valuation allowance (443,914) (327,397) (274,779) (245,884) (221,109)
Noncurrent deferred tax assets, less valuation allowance 26,101 31,603 11,410 15,542 2,702
Depreciation and amortization (7,909) (7,664) — — —
Accounting method change — — (927) (2,047) (2,682)
Operating lease right-of-use assets (18,192) (15,643) (651) (1,484) —
Convertible notes — (8,296) (9,832) (12,011) —
Other — — — — (20)
Noncurrent deferred tax liabilities (26,101) (31,603) (11,410) (15,542) (2,702)
Net deferred tax assets (liabilities) — — — — —

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).


The financial data indicates a consistent accumulation of noncurrent deferred tax assets from 2018 through 2022. Total noncurrent deferred tax assets grew from 223,811 thousand US dollars to 470,015 thousand US dollars over the five-year period, driven primarily by an increase in net operating loss carryforwards and tax credits.

Net Operating Loss (NOL) Carryforwards and Tax Credits
A steady upward trajectory is observed in NOL carryforwards, which rose from 121,748 thousand US dollars in 2018 to 202,459 thousand US dollars in 2022. Similarly, tax credits increased from 64,797 thousand US dollars to 98,292 thousand US dollars. This pattern suggests a sustained period of operating losses and a continuous accumulation of tax attributes that can be used to offset future taxable income.
Valuation Allowance and Asset Realizability
The growth in deferred tax assets is mirrored closely by a corresponding increase in the valuation allowance, which rose from 221,109 thousand US dollars in 2018 to 443,914 thousand US dollars in 2022. The proximity of the valuation allowance to the total noncurrent deferred tax assets indicates a conservative accounting approach, suggesting that the realization of these assets is contingent upon the company achieving future taxable profitability.
Deferred Tax Liability Components
Noncurrent deferred tax liabilities exhibit volatility, reaching a peak of 31,603 thousand US dollars in 2021 before declining to 26,101 thousand US dollars in 2022. This is influenced by fluctuations in operating lease right-of-use assets and convertible notes, as well as a notable shift in accounting method changes in the early part of the period.
Analysis of 2022 Developments
The 2022 fiscal year shows significant spikes in specific liability and asset components. Capitalized R&D increased sharply to 48,047 thousand US dollars from 1,115 thousand US dollars in 2021. Additionally, liabilities related to the sale of future royalties nearly doubled, rising from 38,302 thousand US dollars to 68,366 thousand US dollars. These changes suggest a shift in the company's financing or capitalization strategies during the final year of the observed period.

Overall, the net position of noncurrent deferred tax assets, after the application of the valuation allowance, remained relatively small compared to the gross assets, fluctuating between 2,702 thousand US dollars and 31,603 thousand US dollars. This underscores a high degree of reliance on future revenue generation to utilize the substantial accumulated tax benefits.

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Adjustments to Financial Statements: Removal of Deferred Taxes

Cytokinetics Inc., Financial Data: Reported vs. Adjusted

Cytokinetics Inc., adjustments to financial statements

US$ in thousands

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
Adjustment to Stockholders’ Equity (deficit)
Stockholders’ equity (deficit) (as reported) (107,900) 243,863 113,383 (10,937) 25,934
Less: Net deferred tax assets (liabilities) — — — — —
Stockholders’ equity (deficit) (adjusted) (107,900) 243,863 113,383 (10,937) 25,934
Adjustment to Net Loss
Net loss (as reported) (388,955) (215,314) (127,290) (121,692) (106,289)
Add: Deferred income tax expense (benefit) — — — — —
Net loss (adjusted) (388,955) (215,314) (127,290) (121,692) (106,289)

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).


The financial data reveals a trajectory of widening annual net losses and significant volatility in stockholders' equity over the five-year period from 2018 to 2022. While there were temporary increases in equity during the middle of the period, the overall trend is characterized by deepening operational deficits and a return to a negative equity position by the end of the analyzed timeframe.

Net Loss Trends
A consistent and accelerating increase in net losses is observed. The annual net loss grew from 106.29 million USD in 2018 to 388.96 million USD in 2022. The most substantial increase occurred between 2021 and 2022, where the loss expanded by approximately 81% in a single fiscal year.
Stockholders' Equity Volatility
The equity position exhibits extreme fluctuations. After starting at 25.93 million USD in 2018, the balance fell into a deficit of 10.94 million USD in 2019. A significant recovery occurred in 2020 and 2021, with equity peaking at 243.86 million USD. However, this trend reversed sharply in 2022, resulting in a stockholders' deficit of 107.90 million USD.
Impact of Deferred Tax Adjustments
There is a total identity between the reported and adjusted figures for both stockholders' equity and net loss across all years. The removal of deferred taxes resulted in no numerical change to the financial statements, indicating that deferred tax items did not influence these specific line items during the 2018 through 2022 period.

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Adjusted Financial Ratios: Removal of Deferred Taxes (Summary)

Cytokinetics Inc., Financial Ratios: Reported vs. Adjusted

Cytokinetics Inc., adjusted financial ratios

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
Net Profit Margin
Reported net profit margin -411.21% -305.72% -228.00% -452.93% -337.41%
Adjusted net profit margin -411.21% -305.72% -228.00% -452.93% -337.41%
Financial Leverage
Reported financial leverage — 3.45 4.71 — 8.14
Adjusted financial leverage — 3.45 4.71 — 8.14
Return on Equity (ROE)
Reported ROE — -88.29% -112.27% — -409.84%
Adjusted ROE — -88.29% -112.27% — -409.84%
Return on Assets (ROA)
Reported ROA -38.33% -25.59% -23.85% -41.99% -50.33%
Adjusted ROA -38.33% -25.59% -23.85% -41.99% -50.33%

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).


An analysis of the financial ratios from 2018 to 2022 reveals that the removal of deferred taxes had no impact on the reported figures. All adjusted ratios are identical to their reported counterparts across all metrics and timeframes, indicating that deferred tax adjustments did not influence the calculated margins, leverage, or returns during this period.

Profitability and Margin Trends
The net profit margin remained deeply negative throughout the analyzed period, characterized by significant volatility. A peak deficit was observed in 2019 at -452.93%, followed by a relative improvement in 2020 to -228.00%, before declining again to -411.21% by the end of 2022. Similarly, the return on assets (ROA) remained consistently negative, showing a trend of initial improvement from -50.33% in 2018 to -23.85% in 2020, before deteriorating to -38.33% in 2022.
Solvency and Equity Returns
Financial leverage exhibited a consistent downward trajectory where data was available, decreasing from 8.14 in 2018 to 3.45 in 2021. This reduction suggests a decrease in the reliance on debt relative to equity over time. Concurrently, the return on equity (ROE) remained negative but demonstrated a trend of diminishing losses, improving from -409.84% in 2018 to -88.29% in 2021.

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Adjusted Net Profit Margin

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
As Reported
Selected Financial Data (US$ in thousands)
Net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Revenues 94,588 70,428 55,828 26,868 31,501
Profitability Ratio
Net profit margin1 -411.21% -305.72% -228.00% -452.93% -337.41%
Adjusted for Deferred Taxes
Selected Financial Data (US$ in thousands)
Adjusted net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Revenues 94,588 70,428 55,828 26,868 31,501
Profitability Ratio
Adjusted net profit margin2 -411.21% -305.72% -228.00% -452.93% -337.41%

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).

2022 Calculations

1 Net profit margin = 100 × Net loss ÷ Revenues
= 100 × -388,955 ÷ 94,588 = -411.21%

2 Adjusted net profit margin = 100 × Adjusted net loss ÷ Revenues
= 100 × -388,955 ÷ 94,588 = -411.21%


An analysis of the financial performance from 2018 to 2022 reveals a consistent increase in net losses, with a significant acceleration in the latter part of the period.

Net Loss Trajectory
The net loss experienced a steady climb from 106.29 million US dollars in 2018 to 127.29 million US dollars in 2020. A sharp escalation occurred thereafter, with losses increasing to 215.31 million US dollars in 2021 and reaching 388.96 million US dollars by December 31, 2022, representing a substantial increase in capital consumption.
Adjusted Net Profit Margin Analysis
The net profit margin remained deeply negative throughout the five-year period, characterized by significant volatility. The margin deteriorated to -452.93% in 2019 before showing a relative improvement to -228.00% in 2020. However, this trend reversed in the following years, with the margin declining to -305.72% in 2021 and further deteriorating to -411.21% in 2022.
Comparison of Reported and Adjusted Metrics
A total alignment is observed between reported and adjusted figures for both net loss and net profit margin across all five years. This indicates that there were no significant non-recurring items, extraordinary gains or losses, or specific tax adjustments that required the separation of reported results from adjusted performance metrics during this timeframe.

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Adjusted Financial Leverage

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
As Reported
Selected Financial Data (US$ in thousands)
Total assets 1,014,775 841,319 533,803 289,814 211,178
Stockholders’ equity (deficit) (107,900) 243,863 113,383 (10,937) 25,934
Solvency Ratio
Financial leverage1 — 3.45 4.71 — 8.14
Adjusted for Deferred Taxes
Selected Financial Data (US$ in thousands)
Total assets 1,014,775 841,319 533,803 289,814 211,178
Adjusted stockholders’ equity (deficit) (107,900) 243,863 113,383 (10,937) 25,934
Solvency Ratio
Adjusted financial leverage2 — 3.45 4.71 — 8.14

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).

2022 Calculations

1 Financial leverage = Total assets ÷ Stockholders’ equity (deficit)
= 1,014,775 ÷ -107,900 = —

2 Adjusted financial leverage = Total assets ÷ Adjusted stockholders’ equity (deficit)
= 1,014,775 ÷ -107,900 = —


An analysis of the financial position between 2018 and 2022 reveals significant volatility in stockholders' equity, characterized by multiple shifts between positive equity and deficit positions.

Equity Volatility
Stockholders' equity exhibited a fluctuating pattern, moving from 25.93 million US dollars in 2018 to a deficit of 10.94 million US dollars in 2019. A substantial recovery followed, with equity peaking at 243.86 million US dollars in 2021, before sharply declining to a deficit of 107.90 million US dollars by the end of 2022.
Financial Leverage Trends
Between 2018 and 2021, a consistent downward trend in financial leverage is observed, with the ratio decreasing from 8.14 to 3.45. This contraction suggests a reduction in the proportion of debt relative to equity during this interval. Leverage ratios are absent for 2019 and 2022, corresponding with the years in which the company reported an equity deficit.
Comparison of Reported and Adjusted Metrics
The adjusted stockholders' equity and adjusted financial leverage are identical to the reported values across all periods. This indicates that no adjustments were necessary or applied to the reported figures to arrive at the adjusted financial leverage calculations.

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Adjusted Return on Equity (ROE)

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
As Reported
Selected Financial Data (US$ in thousands)
Net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Stockholders’ equity (deficit) (107,900) 243,863 113,383 (10,937) 25,934
Profitability Ratio
ROE1 — -88.29% -112.27% — -409.84%
Adjusted for Deferred Taxes
Selected Financial Data (US$ in thousands)
Adjusted net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Adjusted stockholders’ equity (deficit) (107,900) 243,863 113,383 (10,937) 25,934
Profitability Ratio
Adjusted ROE2 — -88.29% -112.27% — -409.84%

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).

2022 Calculations

1 ROE = 100 × Net loss ÷ Stockholders’ equity (deficit)
= 100 × -388,955 ÷ -107,900 = —

2 Adjusted ROE = 100 × Adjusted net loss ÷ Adjusted stockholders’ equity (deficit)
= 100 × -388,955 ÷ -107,900 = —


The financial trajectory from 2018 to 2022 is characterized by widening net losses and significant volatility in stockholders' equity, leading to an unstable and deeply negative return on equity (ROE). There is a complete alignment between reported and adjusted figures across all analyzed metrics, indicating that no non-recurring adjustments were applied to these specific line items.

Net Loss Trends
A consistent upward trend in net losses is observed, with the deficit increasing from 106.3 million USD in 2018 to 388.9 million USD in 2022. The rate of loss acceleration intensified significantly after 2020, with the 2022 loss nearly doubling the loss reported in 2021.
Stockholders' Equity Volatility
Stockholders' equity exhibited extreme fluctuations, shifting from a positive position of 25.9 million USD in 2018 to a deficit of 10.9 million USD in 2019. A substantial recovery occurred between 2020 and 2021, peaking at 243.8 million USD, before reverting to a deficit of 107.9 million USD by the end of 2022.
Adjusted Return on Equity (ROE)
The Adjusted ROE remained deeply negative throughout the periods where it was calculable. While the ratio improved from -409.84% in 2018 to -88.29% in 2021, this improvement was primarily driven by the temporary increase in stockholders' equity rather than a reduction in losses. ROE values were not recorded for 2019 and 2022, coinciding with periods of negative stockholders' equity, which renders the ratio mathematically problematic for performance assessment.

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Adjusted Return on Assets (ROA)

Microsoft Excel
Dec 31, 2022 Dec 31, 2021 Dec 31, 2020 Dec 31, 2019 Dec 31, 2018
As Reported
Selected Financial Data (US$ in thousands)
Net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Total assets 1,014,775 841,319 533,803 289,814 211,178
Profitability Ratio
ROA1 -38.33% -25.59% -23.85% -41.99% -50.33%
Adjusted for Deferred Taxes
Selected Financial Data (US$ in thousands)
Adjusted net loss (388,955) (215,314) (127,290) (121,692) (106,289)
Total assets 1,014,775 841,319 533,803 289,814 211,178
Profitability Ratio
Adjusted ROA2 -38.33% -25.59% -23.85% -41.99% -50.33%

Based on: 10-K (reporting date: 2022-12-31), 10-K (reporting date: 2021-12-31), 10-K (reporting date: 2020-12-31), 10-K (reporting date: 2019-12-31), 10-K (reporting date: 2018-12-31).

2022 Calculations

1 ROA = 100 × Net loss ÷ Total assets
= 100 × -388,955 ÷ 1,014,775 = -38.33%

2 Adjusted ROA = 100 × Adjusted net loss ÷ Total assets
= 100 × -388,955 ÷ 1,014,775 = -38.33%


An analysis of the financial performance from 2018 to 2022 reveals a consistent widening of net losses and a fluctuating adjusted return on assets. The identity between reported and adjusted figures throughout the period indicates that no significant non-recurring items or specific tax adjustments were applied to the net loss or ROA calculations.

Net Loss Progression
A sustained upward trend in net losses is observed over the five-year period. Losses increased from -106,289 thousand USD in 2018 to -388,955 thousand USD in 2022. While the increase was relatively gradual between 2018 and 2020, a significant acceleration occurred in 2021 and 2022, with the 2022 loss being approximately 3.6 times the magnitude of the 2018 loss.
Adjusted Return on Assets (ROA) Trends
The adjusted ROA demonstrated a non-linear trajectory. Between 2018 and 2020, the ROA improved from -50.33% to -23.85%, despite the increase in absolute net losses. This suggests a growth in the asset base that outpaced the growth of losses during that interval. However, this positive trend reversed after 2020, with the ROA declining to -25.59% in 2021 and further deteriorating to -38.33% in 2022.

The relationship between the net loss and ROA suggests that while asset growth initially mitigated the impact of operational losses through 2020, the subsequent sharp increase in net losses in 2021 and 2022 overcame any asset expansion, leading to a deterioration in the overall efficiency of asset utilization as measured by the adjusted ROA.

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